Sökresultat

Detta kapitel behandlar teknikens roll för skapandet av användarnas tillit. Kapitlet tar upp tillämpningen av Common Criteria-metodiken (CC) som exempel, och bankernas arbete med att säkra sina system.

A theoretical framework for understanding public library development is presented; plural agonistics is used in combination with an approach inspired by post-humanism. The framework is related to examples from a study of two Swedish public libraries. Antagonism is viewed as foundational, and democracy as an ongoing process, the task being to transform antagonism to agonism, with institutions like

To understand the developmental trajectories in early lymphocyte differentiation, we identified differentially expressed surface markers on lineage-negative lymphoid progenitors (LPs). Single-cell polymerase chain reaction experiments allowed us to link surface marker expression to that of lineage-associated transcription factors (TFs) and identify GFRA2 and BST1 as markers of early B cells. Funct

An increasing number of studies have been focusing on the cognitive abilities and limitations of the designer during the design process, yet thus far only for the conceptual design phase. This paper deals with the embodiment design and detail design phases. We focus on the problem-solving process - strategies and basic steps - around the synthesis activity. Six experiments have been carried out, a

Based on articles published 1990-2004 in 21 LIS journals, a set of co-citation analyses were performed to study changes in research fronts over the last 15 years, where LIS is at now; and to discuss where it is heading. To study research fronts, here defined as current and influential co-cited papers, a citations among documents methodology was applied; and to study changes, the analyses were time

BackgroundSelection of systemic therapy for primary breast cancer is currently based on clinical biomarkers along with stage. Novel genomic tests are continuously being introduced as more precise tools for guidance of therapy, although they are often developed for specific patient subgroups. The Sweden Cancerome Analysis Network – Breast (SCAN-B) initiative aims to include all patients with breast

Checkpoint blockade therapies that reactivate tumour-associated T cells can induce durable tumour control and result in the long-term survival of patients with advanced cancers1. Current predictive biomarkers for therapy response include high levels of intratumour immunological activity, a high tumour mutational burden and specific characteristics of the gut microbiota2,3. Although the role of T c

Filamentous fungi play a key role as decomposers in Earth’s nutrient cycles. In soils, substrates are heterogeneously distributed in microenvironments. Hence, individual hyphae of a mycelium may experience very different environmental conditions simultaneously. In the current work, we investigated how fungi cope with local environmental variations at single-cell level. We developed a method based

The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously

Background: Pulmonary hypertension (PH) is frequent in patients with heart failure and reduced ejection fraction (HFrEF) with 2 different phenotypes: isolated postcapillary PH (IpcPH) and, with the worst prognosis, combined pre- and postcapillary PH (CpcPH). The aims of the present echocardiography study were to investigate (1) the ability to identify PH phenotype in patients with HFrEF using the

In this article, Roybon and colleagues developed a protocol to efficiently and rapidly generate hippocampus neurons from human induced pluripotent stem cells, which they used to model Alzheimer disease and develop a gene therapy approach to modulate the expression of genes involved in synaptic transmission.

Background: Breast cancer (BC) and related treatment are associated with the risk of developing a wide range of persistent disabling impairments. Despite extensive research in the field and an enhanced focus on BC rehabilitation, up to 34-43% of these patients are at risk of developing chronic distress. In addition, it is known that these patients repeatedly report unmet needs, which are strongly