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Identification of COL1A1/2 Mutations and Fusions With Noncoding RNA Genes in Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion)

Bizarre parosteal osteochondromatous proliferation (BPOP) (Nora lesion) is a benign bone surface lesion, which most commonly occurs in the digits of young patients and has a high rate of recurrence. Histologically, it is composed of a mixture of disorganized bone, cartilage, and spindle cells in variable proportions and characterized by amorphous "blue bone" mineralization. Recurrent chromosomal a

Parallel motion vision pathways in the brain of a tropical bee

Spatial orientation is a prerequisite for most behaviors. In insects, the underlying neural computations take place in the central complex (CX), the brain’s navigational center. In this region different streams of sensory information converge to enable context-dependent navigational decisions. Accordingly, a variety of CX input neurons deliver information about different navigation-relevant cues.

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and m

Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of multi-modal data makes integration and inference a non-trivial task. We developed a deep-learning-based framework, multi-omics variational autoencoders (MOVE), to integrate suc

Pulmonary Hypertension Phenotype Can Be Identified in Heart Failure With Reduced Ejection Fraction Using Echocardiographic Assessment of Pulmonary Artery Pressure With Supportive Use of Pressure Reflection Variables

Background: Pulmonary hypertension (PH) is frequent in patients with heart failure and reduced ejection fraction (HFrEF) with 2 different phenotypes: isolated postcapillary PH (IpcPH) and, with the worst prognosis, combined pre- and postcapillary PH (CpcPH). The aims of the present echocardiography study were to investigate (1) the ability to identify PH phenotype in patients with HFrEF using the

Cell-specific switch for epileptiform activity : critical role of interneurons in the mouse subicular network

During epileptic seizures, neuronal network activity is hyper synchronized whereby GABAergic parvalbumin-interneurons may have a key role. Previous studies have mostly utilized 4-aminopyridine to induce epileptiform discharges in brain slices from healthy animals. However, it is not clear if the seizure-triggering ability of parvalbumin-interneurons also holds true without the use of external conv

Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling

Breast tumors of the basal-like, hormone receptor-negative subtype remain an unmet clinical challenge, as there is high rate of recurrence and poor survival in patients following treatment. Coevolution of the malignant mammary epithelium and its underlying stroma instigates cancer-associated fibroblasts (CAFs) to support most, if not all, hallmarks of cancer progression. Here we delineate a previo

Familial Aggregation of Aortic Valvular Stenosis : A Nationwide Study of Sibling Risk

Background - Aortic valvular stenosis (AS) is the most common cause of cardiac valvular replacement surgery. During the last century, the pathogenesis of AS has undergone transitions in developed countries, from rheumatic heart disease to a degenerative calcific pathogenesis. Although a familial component has been described for a subset of cases with a bicuspid valve, data are limited on the overa

Motor Imagery to Facilitate Sensorimotor Re-Learning (MOTIFS) after traumatic knee injury: : study protocol for an adaptive randomized controlled trial

BackgroundTreatment following traumatic knee injury includes neuromuscular training, with or without surgical reconstruction. The aim of rehabilitation is to restore muscle function and address psychological factors to allow a return to activity. Attention is often on rehabilitation of knee function, but deficiencies often persist. Specific interventions addressing psychological factors are sparin

The myeloid cell biomarker EMR1 is ectopically expressed in colon cancer

OBJECTIVE: The microenvironment of colon cancer (CC) is heterogeneous including cells of myeloid lineage affecting tumor growth and metastasis. Two functional subtypes of myeloid cells have been identified; one (M1) is tumor-inhibitory and the other one (M2) is tumor-promoting. Whether the three myeloid markers EMR1, CD206 and CD86 are expressed only in the infiltrating myeloid cells or also in th

Måla hela området rött - en studie av dörrknackning som retorisk situation

Denna studie undersöker den politiska kampanjmetoden dörrknackning (canvassing) med syftet att få en inblick i hur dörrknackarna upplever den retoriska situationen ute i fält. Det empiriska materialet har samlats in genom tio kvalitativa forskningsintervjuer och analyserats med Lloyd F. Bitzers modell “The Rhetorical Situation” (1968). Slusatserna är att dörrknackning som metod är situationell i sThis study examines the rhetorical situation of door-to-door canvassing through qualitative research interviews with partisan canvassers from the Social Democratic Party in Malmö, Sweden, with the theoretical framework of Lloyd F. Bitzer's "The Rhetorical Situation" (1968). The study concludes that door-to-door canvassing is situational in its form, and must therefore respond to audi

Comparing Chemical Reaction Mechanisms for Jet Fuel in Turbulent Premixed Combustion Simulations

The compositions of alternative jet fuels can vary radically, and the consequences of these differences are a subject of ongoing investigation. Numerical combustion simulations are vital to this research and require chemical reaction mechanisms that efficiently and accurately capture the chemical pathways of combustion. Here, we present the recently developed Z79 collection of small pathway-centri

Comparing non-ischaemic heart preservation (NIHP) with ischaemic static cold storage of donor hearts in adult cardiac transplantation : study protocol for a randomised controlled trial

Introduction Ischaemia-reperfusion (I/R) injury remains a major challenge in heart transplantation, with mortality risk increasing significantly when allograft ischaemic time exceeds 4 hours. Non-ischaemic heart preservation (NIHP), using continuous hypothermic perfusion, has shown promise in preliminary studies for reducing I/R injury and improving outcomes. This randomised controlled trial aims

Dan moran

Microsoft Word - Moran_LUMES_Thesis 29.doc Embodied Ecological Footprints in International Trade LUMES Master’s Thesis Daniel Moran1 Supervisor: Barry Ness2 1 14701 Farwell Ave. Saratoga, CA 95070 USA 2 LUCSUS, Lund University, Sölvegatan 10 4° van, Lund 222-44 SWEDEN Abstract Nations import and export biophysical resources. With many ecosystems worldwide under mounting stress, countries may be in

https://www.lumes.lu.se/sites/lumes.lu.se/files/dan_moran.pdf - 2026-05-30

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M al m ö A rt A ca de m y M al m ö A rt A ca de m y 20 16  –  2 01 7 20 16  –  2 01 7 20 16  –  2 01 7 Gertrud Sandqvist Professor of Art Theory and the History of Ideas; Supervisor for the Doctoral Programme Dr. Sarat Maharaj Professor of Visual Art and Knowledge Systems; Supervisor for the Doctoral Programme Dr. Matts Leiderstam Professor of Fine Arts Haegue Yang Professor of Fine Arts Joachim K

https://www.khm.lu.se/en/sites/khm.lu.se.en/files/171120_maa_mq.pdf - 2026-05-30

Cec klimatpocket 12mb

15 nedslag i klimat- forskningen DåtiD NutiD framtiD | LuNDs uNiversitet / 03 / redaktörer Marianne Hall & ingela Björck 15 nedslag i klimat- forskningen DåtiD NutiD framtiD | LuNDs uNiversitet / 04 / 15 NeDsLag i kLimatforskNiNgeN DåtiD, NutiD, framtiD Sammanställd av Klimatinitiativet vid Lunds universitet Projektledare: Markku Rummukainen Utgiven av: Centrum för miljö- och klimatforskning, Lund

https://www.hallbarhet.lu.se/sites/hallbarhet.lu.se/files/cec_klimatpocket_12mb.pdf - 2026-05-30

Program - halsovetenskapens dag 2020

Hälsovetenskapens dag arrangeras årligen av Institutionen för hälsovetenskaper vid Medicinska fakulteten. I år presenteras aktuell forskning på temat ”Implementering av nya arbetssätt i vård och samhälle”. Ta del av ett intressant och innehållsrikt program med föreläsningar, science slam och möjligheten att ställa frågor till våra forskare. För vem Yrkesverksamma inom hälso- och sjukvården, forska

https://www.medicin.lu.se/sites/medicin.lu.se/files/program_-_halsovetenskapens_dag_2020.pdf - 2026-05-30