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Atrial fibrillation (AF) is a prevalent and morbid abnormality of the heart rhythm with a strong genetic component. Here, we meta-analyzed genome and exome sequencing data from 36 studies that included 52,416 AF cases and 277,762 controls. In burden tests of rare coding variation, we identified novel associations between AF and the genes MYBPC3, LMNA, PKP2, FAM189A2 and KDM5B. We further identifie

Studies of the surface chemistry of the first few cycles of atomic layer deposition (ALD) using in situ and time-resolved operando techniques are attractive for realizing, understanding, and obtaining true mechanistic information during the deposition. However, the latter techniques are yet to be applied to ALD of metal nitrides. Here, we present a surface-chemistry investigation through a time-re

X-rays are commonly used in imaging experiments due to their penetration power, which enables non-destructive resolution of internal structures in samples that are opaque to visible light. Time-resolved X-ray tomography is the state-of-the-art method for obtaining volumetric 4D (3D + time) information by rotating the sample and acquiring projections from different angular viewpoints over time. Thi

Time- and Angle-Resolved Photoelectron Spectroscopy (tr-ARPES) is employed to monitor photoexcited electrons in the 2D hybrid perovskite (BA) (Formula presented.) (MA) (Formula presented.) (Formula presented.) (Formula presented.). Photoelectron intensity maps are in good agreement with ab-initio calculations of the band structure. The effective mass is (Formula presented.) and (Formula presented.

Multi-beam ptychography (MBP) offers a scalable solution to improve the throughput of state-of-the-art ptychography by increasing the number of coherent beams that illuminate the sample simultaneously. However, increasing the number of beams in ptychography makes ptychographical reconstructions more challenging and less robust. It has been demonstrated that MBP reconstructions can be made more rob

We derive an explicit link between Gaussian Markov random fields on metric graphs and graphical models, and in particular show that a Markov random field restricted to the vertices of the graph is, under mild regularity conditions, a Gaussian graphical model. This graphical model has a distribution which is faithful to its pairwise independence graph, that coincides with the neighbor structure of

Background: Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) enables sensitive detection and staging of prostate cancer, yet its relationship with long-term survival remains unclear. This study aimed to assess whether total lesion volume (TLV) measured on [18F]PSMA-1007 PET/CT predicts overall survival (OS) in prostate cancer patients. Methods: A co

The field of general-purpose robotics has recently embraced powerful probabilistic diffusion-based models to learn the complex embodiment behaviours. However, existing models often come with significant trade-offs, namely high computational costs for inference and a fundamental inability to quantify output uncertainty. We introduce Normalizing Flows Policy (NF-P), a conditional normalizing flow-ba

Chaperone proteins are essential for maintaining proteostasis. Their main role is to assist with the folding of other proteins and to prevent the aggregation of misfolded proteins. The molecular chaperone DNAJB6b efficiently suppresses amyloid formation of several peptides. This activity may rely on the same physicochemical properties as those driving chaperone self-assembly into large micellar-li

The unprecedented x-ray flux density provided by modern x-ray sources offers new spatiotemporal possibilities for x-ray imaging of fast dynamic processes. Approaches to exploit such possibilities often result in either (i) a limited number of projections or spatial information due to limited scanning speed, as in time-resolved tomography, or (ii) a limited number of time points, as in stroboscopic

Context: AI technologies are increasingly embedded in products and software engineering processes of industrial IoT, autonomous systems, and cyber-physical systems. It is therefore essential to ensure alignment with safety, reliability, and ethical standards. However, practical software engineering methods for managing misalignment risks remain underdeveloped. Objective: This study aims to explore

Migratory birds have evolved a multitude of physiological and behavioural adaptations to reach their population-specific wintering areas during their first migration. The endogenous program encodes distance, direction and fuelling, and involves species-specific adaptations leading naïve migratory birds along highly diverse routes. While daylength has been extensively studied in relation to the ons

Social movements have been argued to be important political actors because of their ability to apply pressure and mobilizing governments to take policy action on societal problems. In light of this, it is the aim of this thesis to investigate if a feminist movement in the UK, called the IC Change campaign, can serve as the explanation as to why the UK government put forward a new policy proposal o

De riskreducerande åtgärder som ska införas när byggnader placeras nära farliga riskkällor verkar ibland kunna förändras eller till och med försvinna innan byggprojektet är färdigt. Detta kan bero på svårigheter med kommunikation, men det finns även andra orsaker. I ett samhälle kan det finnas industrier som sysslar med giftiga kemikalier eller godståg som fraktar farliga ämnen. Detta kan medfBuildings are sometimes raised in the vicinity of risk objects such as hazardous industries and routes used for transportation of hazardous goods. To compensate for the increased risk level risk reducing measures can be implemented. However, the planning and construction process is long and complex, and for these measures to be implemented they must somehow be conveyed through this process. The pu

Within Peace Research, there is a long tradition of studying the creations and conditions of peace. Within this, Hybrid Peace Theory has constituted a more critical strand, emphasising the importance of the interactions between international and local actors. This thesis has aimed to contribute to critical peace research by arguing for the importance of including a gender perspective on the Hybrid

Purpose - The purpose of this research is to investigate how the business network develops, when habitual entrepreneurs enter into a different industry context. How these entrepreneurs expand their existing networks, and how they build new networks, when entering new industry context. Design - Qualitative analysis. Findings are primarily based on semi-structured interviews with ten habitual entr

This paper deals with the implementation of model selection criteria to data generated by ARMA processes. The recently introduced modified divergence information criterion is used and compared with traditional selection criteria like the Akaike information criterion (AIC) and the Schwarz information criterion (SIC). The appropriateness of the selected model is tested for one- and five-step ahead p

The main interest of designers is not only to determine the amplitudes of tillage forces but also the type of their distributions under different soil mechanical properties with object of achieving reliable designs. Whereas, the deterministic design approach consists in achieving designs without considering the randomness of the design parameters that may lead to non reliable designs. In this work

AimPeak oxygen uptake (VO2peak) is closely related to total heart volume (THV) in healthy individuals. This study aimed to investigate 1) the association between VO2peak and THV in subjects with subclinical diastolic dysfunction, athletes, healthy controls, and patients with established heart failure with and without preserved ejection fraction (HFpEF, HFrEF), and 2) whether VO2peak/THV-index can

Seminar date: 30th May 2012 Course: BUSN68Degree Project - Accounting and Management Control Authors: Kateryna Mumrenko& Alexandra Zăinescu Supervisors: Per Magnus Andersson& Johan Dergård Five key words: Process of innovation, Management control, project management, R&D, formal and informal control tools. Purpose: The purpose of this thesis is to describe and analyze how the process o