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The neuroprotective effect of the glial cell line-derived neurotrophic factor has been extensively studied in various toxic models of Parkinson's disease. However, it remains unclear whether this neurotrophic factor can protect against the toxicity induced by the aggregation-prone protein α-synuclein. Targeted overexpression of human wild-type α-synuclein in the nigrostriatal system, using adeno
To study cortical re-organisation after acute hand deafferentation, we investigated 10 experimental subjects and 10 controls for function in the left hand, before, during and after tourniquet induced anaesthesia of the right hand. fMRI was performed in three experimental subjects. Tourniquet-induced right hand anaesthesia resulted in rapid significant improvement in grip strength, tactile discrimi
There is an increasing consensus that individual adaptive capacities are critical to successfully adapt to climate change and achieve sustainable development. However, little is known about adaptive practices, particularly in developed countries. Against this background, this paper investigates the strategies used by Swedish citizens to adapt to (changing) climatic variability and extremes. It off
The interaction among various stakeholder organizations in modern crisis response is very similar to negotiation where each organization has its own goal in addition to a common goal. Decision makers in stakeholder organizations most often have to settle for win-win situations to attain higher joint benefit. In such cases willingness to contribute in joint tasks becomes a prerequisite. In our pres
Recent studies in animal models of Parkinson's disease (PD) have provided evidence that dopamine released from spared serotonin afferents can act as a trigger of dyskinetic movements induced by repetitive, low doses of levodopa. Serotonin neurons have the capacity to store and release dopamine synthesized from systemically administered levodopa. However, because of the lack of any autoregulatory f
Order Picking in warehouses is often optimized using a method known as Order Batching, which means that one vehicle can be assigned to pick a batch of several orders at a time. There exists a rich body of research on Order Batching Problem (OBP) optimization, but one area which demands more attention is computational efficiency, especially for optimization scenarios where warehouses have unconvent
Context. In the era of large spectroscopic surveys, massive databases of high-quality spectra coupled with the products of the Gaia satellite provide tools to outline a new picture of our Galaxy. In this framework, an important piece of information is provided by our ability to infer stellar ages, and consequently to sketch a Galactic timeline. Aims. We aim to provide empirical relations between s
Objective: To investigate the risk of stillbirth or neonatal death before 45 post-menstrual weeks in relation to gestational duration, stratified by body mass index (BMI) and parity. Design: Retrospective study. Setting: Data from the Swedish Medical Birth Register. Population: Singleton, cephalic births at between 39+0 and 42+2 weeks of gestation, 2005–2016 (n = 892 339). Methods: Relative risk r
Under början av förra seklet skedde en formlig reception av tysk processrätt genom Ernst Kallenbergs verk Svensk Civilprocessrätt i två band. Således kom läran om processföremålet genom 1942 års processreform att läggas till grund för utformningen av den svenska rättegångsbalken (RB). Läran om processföremålet innebär att saken är den omtvistade rättigheten i det bakom-liggande rättsförhållande soAt the turn of the last century, a formal reception of German procedural law took place through Ernst Kallenberg’s work ’Svensk Civilprocessrätt’ in two volumes. Thereby, the German doctrine on the essence of the claim formed the basis for the Swedish Code of Procedure, rättegångsbalken (RB), through the procedural reform of 1942. The doctrine on the essence of the claim holds that the matter cont
Significant behavioral changes will need to be implemented to prevent the energy supply sector from tripling CO2 emissions by the midcentury. However, within the academic research, behavior changes remain primarily focused on the individual level, while the behavior of companies that are responsible for elevated greenhouse gas emissions falls behind. This master’s thesis analyses the core values
Background Increased postoperative cardiac troponin (cTn) independently predicts short-term mortality. Previous studies suggest that preoperative cTn also predicts major adverse cardiovascular events (MACE) and mortality after noncardiac surgery. The value of preoperative and perioperative changes in cTn as a prognostic tool for adverse outcomes has been sparsely investigated. Methods and findings
The four major satellites of Jupiter, known as the Galilean moons, and Saturn's most massive satellite, Titan, are believed to have formed in a predominantly gaseous circum-planetary disk during the last stages of formation of their parent planet. Pebbles from the protoplanetary disk are blocked from flowing into the circumplanetary disk by the positive pressure gradient at the outer edge of the p
Context. The extensive stellar spectroscopic datasets that are available for studies in Galactic Archeaology thanks to, for example, the Gaia-ESO Survey, now benefit from having a significant number of targets that overlap with asteroseismology projects such as Kepler, K2, and CoRoT. Combining the measurements from spectroscopy and asteroseismology allows us to attain greater accuracy with regard
Capacity development for disaster risk reduction is an important process to substantially reduce disaster losses, which threaten sustainable development and the achievement of the Millennium Development Goals. This paper presents a theoretical framework with seven elements for capacity development for disaster risk reduction that has been tested in practise with noteworthy results. The seven eleme
Lead halide perovskites (LHPs) nanocrystals (NCs), owing to their outstanding photophysical properties, have recently emerged as a promising material not only for solar cells but also for lighting and display applications. The photophysical properties of these materials can be further improved by chemical engineering such as cation exchange. Hot carrier (HC) cooling, as one of the key photophysic
Context. Streaming instability is a key mechanism in planet formation, clustering pebbles into planetesimals with the help of self-gravity. It is triggered at a particular disk location where the local volume density of solids exceeds that of the gas. After their formation, planetesimals can grow into protoplanets by feeding from other planetesimals in the birth ring as well as by accreting inward
We demonstrate experimentally and theoretically a controllable way of shifting the frequency of an optical pulse by using a combination of spectral hole burning, slow light effect, and linear Stark effect in a rare-earth-ion-doped crystal. We claim that the solid angle of acceptance of a frequency shift structure can be close to 2π, which means that the frequency shifter could work not only for op
