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Background: In adults and adolescents with asthma, use of ≥3 short-acting β2-agonist (SABA) canisters/year is associated with increased exacerbation risk. Whether this association is present in younger children remains unknown. In this SABA use IN Asthma (SABINA) Junior study, we assessed the association of SABA collection with exacerbation risk in the general Swedish pediatric asthma population.

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This article critically examines the approach of technical experts, including engineers, natural scientists, architects, planners, and other practitioners, who are attempting to create more sustainable forms of economic development, environmental protection, and social equity. The authors identify four principal characteristics of expertise–ontological assumptions, epistemological approaches, powe

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Chronic breathlessness occurs across many different conditions, often independently of disease severity. Yet, despite being strongly linked to adverse outcomes, the consideration of chronic breathlessness as a stand-alone therapeutic target remains limited. Here we use data-driven techniques to identify and confirm the stability of underlying features (factors) driving breathlessness across differ

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Exact cover is a non-deterministic polynomial time (NP)-complete problem that is central to optimization challenges such as airline fleet planning and allocation of cloud computing resources. Solving exact cover requires the exploration of a solution space that increases exponentially with cardinality. Hence, it is time- and energy consuming to solve large instances of exact cover by serial comput

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We are interested in studying sets of the form U ( α ) := { x ∈ X : ∃ M = M ( x ) ⩾ 1 such that ∀ N ⩾ M , ∃ 1 ⩽ n ⩽ N such that d ( T n x , x ) ⩽ | λ | − α N } , where ( X , T , d ) is our metric dynamical system and | λ | > 1 . Although many results exist for the one dimensional case, not as many are known for systems in higher dimensions and especially in the hyperbolic case. We consider X = T 2

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There are currently increasing concerns about escalating crude oil prices, depleted petroleum resources, and environmental damages caused by plastics. In light of this, bio-based and biodegradable materials, such as polyhydroxyalkanoates (PHAs), have gained global attention from industry and academia as sustainable alternatives to petroleum-based materials. Poly-hydroxybutyrate (PHB) is the simple

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Allergic contacts dermatitis is a major health problem in the world and the disease is caused by a type IV hypersensitivity to a small chemical called a hapten. These substances are common in cosmetics, perfumes, pharmaceuticals and house-hold products, and risk factors include both inherent factors and frequent or high exposure. Hazard assessment and potency classification of sensitizers are ther

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The research is done in order to analyse management of waste beverage containers in Belarus and the effectiveness of policies implemented to address it. The analysis is followed by exploring whether the introduction of deposit-refund system (DRS) would help to address packaging waste issue in Belarus and, if so, what features the DRS should possess to be effective in current context. The study des

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According to Art. 58 VAT Directive digital services are to be taxed at the place where the customer resides. The Implementing Regulation provides certain presumptions for suppliers to determine that place. These presumptions are analysed in this thesis regarding their actual compliance effort for companies, as well as the implementation of the destination principle. But before, the conditions and

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Den process där nya länder går med Europeiska unionen (EU) kallas utvidgning. Det har haft en central roll i unionens utveckling. Sedan grundandet har EU vuxit från sex till tjugosju medlemsländer, under totalt sju utvidgningsomgångar. För närvarande är fem länder kandidater för medlemskap: Montenegro, Serbien, Albanien, Nordmakedonien och Turkiet. Kosovo och Bosnien och Hercegovina är potentiellaEnlargement, the process whereby countries join the European Union (EU), has had a key role in the Union’s development. Since its founding, the EU has grown from six to twenty-seven Member States, in a total of seven enlargement rounds. Currently, five countries are candidates for membership: Montenegro, Serbia, Albania, North Macedonia and Turkey. Kosovo and Bosnia and Herzegovina are recognised

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First, the thesis establishes that non-refoulement obligation is jus cogens norms. Before establishing the peremptoriness of the given legal norm, the account of the concept of jus cogens is proposed within which such elevation occurs. The argument suggests that jus cogens non-refoulement obligation complemented with the various conceptual and normative objections undermine the conceptual viabilit

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There is a growing interest in integrating indoor and outdoor spaces and our experiences on both sides. Nevertheless, despite being a constant topic in architectural research, there is little academic work that shows the role of furniture as great tools for creating that connection. This degree project aims to show the enormous potential of furniture to be a useful tool to connect indoor and outd

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Phosphate is fundamental for optimal growth and reproduction for plants. However, due to low solubility, not all phosphorus in the soil is available to the plant. It has recently been discovered that plants can take up complex phosphate-containing organic compounds, such as phospholipids. This depends on membrane transporters, more specifically lipid flippases. In the model plant Arabidopsis, the

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Enzymatic removal of blood group ABO antigens to develop universal red blood cells ( RBCs) was a pioneering vision originally proposed more than 25 years ago. Although the feasibility of this approach was demonstrated in clinical trials for group B RBCs, a major obstacle in translating this technology to clinical practice has been the lack of efficient glycosidase enzymes. Here we report two bacte

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This study was designed to investigate suicide attempters' views on problems underlying their suicidal behavior. A questionnaire comprising 17 problems was presented to 54 non-consecutive patients (men/women=25/29, mean age 36 ±14 years) admitted to a specialized psychiatric ward following an attempt. (In the large majority of cases the method was self-poisoning. 37% had previously attempted suici

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We propose a Viterbi-type decoder for tailbiting trellis codes that works by traversing the tailbiting circle somewhat more than once. The traversal is the least possible for any bounded distance Viterbi decoder. Procedures are given that compute this minimum. Unlike previous decoders of the type, the new scheme does not suffer limit cycles or from pseudocodewords. The bit-error rate is compared t

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We establish the local well-posedness for a new nonlinearly dispersive wave equation and we show that the equation has solutions that exist for indefinite times as well as solutions which blowup in finite time. Furthermore, we derive an explosion criterion for the equation and we give a sharp estimate from below for the existence time of solutions with smooth initial data.

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Microalgae enhance the removal of nutrients, organic contaminants, heavy metals, and pathogens from domestic wastewater and furnish an interesting raw material for the production of high-value chemicals (algae metabolites) or biogas. Photosynthetic oxygen production also reduces the need for external aeration, which is especially advantageous for the treatment of hazardous pollutants that must be