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Separation of biomolecules using Open-Loop Non-Isocratic Simulated moving bed (SMB) technology

In biotechnological industries, downstream processing is a bottleneck in the complete production process. There is a wish to reduce the costs and therefore one tries to operate separation technology in continuous mode. Conventional SMB is a continuous countercurrent separation process, which is based on mathematical modeling and simulation studies for separation of binary mixtures of components.