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Here we studied the effects of glial cell line-derived neurotrophic factor (GDNF) in a rat model that represents the symptomatic stages of Parkinson's disease. GDNF was infused starting 2 weeks after an intrastriatal 6-hydroxydopamine (6-OHDA) lesion in order to halt the ongoing degeneration of the nigrostriatal dopaminergic neurons. GDNF or vehicle was infused in the striatum or the lateral ventr
Background and Objectives. Mantle cell lymphoma (MCL) is an aggressive disease. Patients with this malignancy have a median survival of 3 years. To better understand disease progression, which is characterized by increased proliferation, we analyzed the gene expression of MCL with different proliferative indices, as determined by immunohistochemical staining for Ki-67. Furthermore, primary and rel
This thesis investigates ruin probabilities and first passage times for self-similar processes. We propose self-similar processes as a risk model with claims appearing in good and bad periods. Then, in particular, we get the fractional Brownian motion with drift as a limit risk process. Some bounds and asymptotics for ruin probability on a finite interval for fractional Brownian motion are derive
Sustainability has been on the agenda for decades. Yet it is not evident that the development we are witnessing can qualify as sustainable. Departing from an understanding of the adoption of sustainability as an on-going, unfinished process the thesis explores conditions for sustainability in Swedish transport infrastructure policy and planning. The study covers decision processes of three mega-pr
Historically, agriculturally induced CO2 release from soils has contributed to rising levels in the atmosphere. However, by using appropriate management, soils can be turned into carbon sinks. Many of the dryland regions of the world are characterised by degraded soils, a high incidence of poverty and a low capacity to invest in agriculture. Two well-proven soil organic matter models (CENTURY 4.0
Prostacyclin is the major arachidonic acid metabolite of the vascular endothelium and is produced mainly via the cyclooxygenase-2 pathway. By acting on the prostacyclin (IP) receptor on platelets and vascular smooth muscle cells, prostacyclin exerts vasodilatory and antiaggregative/antiadhesive effects. Previous studies have shown that prostacyclin production increases after brain trauma, but the
We study inhomogeneous random graphs in the subcritical case. Among other results, we derive an exact formula for the size of the largest connected component scaled by logn, with n being the size of the graph. This generalizes a result for the "rank-1 case". We also investigate branching processes associated with these graphs. In particular, we discover that the same well-known equation for the su
Novel materials in microfluidics can enable innovative applications, price reductions, higher efficiency, and increased availability. In this thesis, I examine polymer materials for acoustofluidic applications, and find several functioning, and promising, materials and designs. Microfluidics involves manipulating small volumes of fluids for novel applications, and acoustofluidics describes the ap
Östersjön har stora problem med övergödning, eutrofiering, vilket beror på en ökad transport av näringsämnen från omgivande länder. Näringen kommer främst i form av kväve och fosfor från jordbruket och transporteras ut i Östersjön via floder. Framförallt kväve har stor påverkan på övergödningen, som i sin tur leder till fiskdöd, algblomning och syrefria bottnar i sjöar. I den här studien ska läckEutrophication problems in the Baltic Sea have drawn attention to the contribution of nutrients from surrounding countries. The problems have attracted considerable attention to non-point source nitrogen pollution of rivers and lakes. The ability to predict nitrogen export from inland sources is essential in order to evaluate the effects of anthropogenic activities, of which the leakage from agric
Recently, seven Earth-sized planets were discovered around the M-dwarf star TRAPPIST-1. Thanks to transit-timing variations, the masses and therefore the bulk densities of the planets have been constrained, suggesting that all TRAPPIST-1 planets are consistent with water mass fractions on the order of 10%. These water fractions, as well as the similar planet masses within the system, constitute st
Aims: This study aimed to examine the population-based Skåne Health-care Register (SHR) regarding feasibility for scientific research and also strengths and weaknesses. Methods: To analyse the feasibility of the SHR, we performed a bibliographic search for peer-reviewed articles based on SHR data from 2000 to 2018. To analyse strengths and weaknesses, we used original SHR data about coverage and v
A search for the Standard Model Higgs boson in proton-proton collisions with the ATLAS detector at the LHC is presented. The datasets used correspond to integrated luminosities of approximately 4.8 fb(-1) collected at, root s = 7 TeV in 2011 and 5.8 fb(-1) at root s = 8 TeV in 2012. Individual searches in the channels H -> ZZ(()*()) -> 4l, H -> gamma gamma and H -> WW (()*()) -> ev mu v in the 8 T
Chagas disease, also known as American Trypanosomiasis, is a parasitic infection caused by the triatomine bugs, commonly referred to as kissing bugs. It is the deadliest parasitic disease in South America but has spread beyond this region due to migration and climate change. Approximately 70 million people are at risk of infection, and there is no cure for the chronic phase of the disease. In prev
The construction of episodic memory is an automatic process. Event segmentation theory proposed that segmentation of the continuous perceptual stream into separate memory events occurs when changes in external boundaries lead to changes in internal perceptual and conceptual boundaries. The influence of perceptual and conceptual boundaries on episodic memory encoding has been the subject of intensi
Behandling av personuppgifter, vilket undersöks i denna uppsats, sker i den offentliga och privata sektorn, och i organisationer av alla storlekar. Personuppgiftsbehandlingar förekommer i varje gren av en organisation och hos alla olika aktörer, inom så spridda områden som rättsväsendet eller en frisörsalong. Mer specifikt syftar denna uppsats till att studera definitionen av "behandling"Personal data processing, as will be examined in this thesis, occurs in the public and the private sectors, in organisations of every size. It occurs in every branch of an organisation and by all different actors, be it law-enforcement or a hairdresser saloon. More specifically this thesis aims to study the definition of ‘processing’ and attempts to highlight the features and characterisation of i
OBJECTIVE: To investigate the relation between biomarkers of inflammation and subsequent development of giant cell arteritis (GCA).METHOD: Participants in the population-based Malmö Diet Cancer Study (MDCS; N = 30447), established 1991-1996, who were subsequently diagnosed with GCA, were identified in a structured process. GCA-free controls, matched for sex, year of birth, and year of screening we
