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Background Clinical outcomes after major surgery are poorly described at the national level. Evidence of heterogeneity between hospitals and health-care systems suggests potential to improve care for patients but this potential remains unconfi rmed. The European Surgical Outcomes Study was an international study designed to assess outcomes after non-cardiac surgery in Europe.Methods We did this 7
Neurofilament light (NfL) is a marker of neuroaxonal injury, a prominent feature of Alzheimer's disease. It remains uncertain, however, how it relates to amyloid and tau pathology or neurodegeneration across the Alzheimer's disease continuum. The aim of this study was to investigate how plasma NfL relates to amyloid and tau PET and MRI measures of brain atrophy in participants with and without cog
Aim: The first Swedish National Guidelines for Ovarian Cancer (NGOC) were published in 2012. We aimed to evaluate surgical outcomes and survival in patients with stage IIIC-IV disease, before and after the NGOC implementation. Method: Women with primary epithelial ovarian cancer, FIGO stage IIIC–IV, registered in the Swedish Quality Registry for Gynecologic Cancer 2008–2011 and 2013–2016 were incl
Increasingly fine-grained cloud billing creates incentives to review the software execution footprint in virtual environments. For example, virtual execution environments move towards lower overhead: from virtual machines to containers, unikernels, and serverless cloud computing. However, the execution footprint of security components in virtualized environments has either remained the same or eve
The scan-on-receive (SCORE) is a key digital beamforming (DBF) technique for future high-resolution wide-swath synthetic aperture radar (SAR) systems. A sharp and high gain receive beam, steered in real time towards the expected direction of arrival (DoA) of the backscattering signal, allows for improved SAR imaging performance with respect to a conventional approach. Nevertheless, it also exposes
Background: The complexity of pancreaticoduodenectomy and fear of morbidity, particularly postoperative pancreatic fistula, can be a barrier to surgical trainees gaining operative experience. This meta-analysis sought to compare the postoperative pancreatic fistula rate after pancreatoenteric anastomosis by trainees or established surgeons. Methods: A systematic review of the literature was perfor
Smart vision sensor systems enable many computer vision applications such as autonomous drones and wearable devices. These battery-powered gadgets have very stringent power consumption requirements. Close-to-sensor feature extraction compressing the full image into descriptive keypoints, is crucial as it allows for several design optimizations. First, the amount of necessary on-chip memory can be
Background: Cadmium (Cd) exposure during gestation has been associated with altered DNA methylation at birth, but it is not known if the changes in methylation persist into childhood. Objectives: To evaluate whether gestational Cd-related changes of DNA methylation persist from birth to 9 years of age. Methods: We studied mother–child dyads in a longitudinal cohort in rural Bangladesh. Cadmium con
Background: Sexual harassment (SH) in the workplace is prevalent and associated with poor health. Universities are large workplaces with complex formal and informal power relations, which may influence the prevalence of SH. Although employees and students share the university context, few studies on SH have included both groups. The overall aim of the study was to investigate SH among employees an
Understanding and measuring security of softwarein terms of vulnerability metrics is important when reviewingand deciding between softwares. The large number of disclosedvulnerabilities will continue to expose software intensivesystems and products to attacks, and the choice of thirdparty software will affect stability and reliability of productsincorporating this software. We collect CVE data fro
Security has been recognized as a leading barrier for IoT adoption. The growing number of connected devices and reported software vulnerabilities increases the importance firmware updates. Maturity models for software security do include parts of this, but are lacking in several aspects. This paper presents and evaluates a maturity model (HAVOSS) for handling vulnerabilities in third party OSS and
Biological effects of electromagnetic fields (EMF) on the blood‐brain barrier (BBB) can be studied in sensitive and specific models. In a previous investigation of the permeability of the blood‐brain barrier after exposure to the various EMF‐components of proton magnetic resonance imaging (MRI), we found that the exposure to MRI induced leakage of Evans Blue labeled proteins normally not passing t
In recent years, it has been recognized that the seismic wave equation solved with a finite-difference method in time causes a predictable and removable error through the use of so-called time-dispersion transforms. These transforms were thought not to apply to visco-elastic media. However, in this paper we demonstrate that the time-dispersion transforms remain applicable when the visco-elastic wa
Signal apparition is a recent signal processing advance that has numerous applications in seismic data acquisition and processing. In this paper we review the basic principles of signal apparition and discuss applications related to simultaneous source acquisition. We discuss the generalization of the technique to large number of sources and the application in a full 3D configuration enabling larg
Background: The increasing trends in cesarean delivery are globally acknowledged. However, in many low-resource countries, socioeconomic disparities have created a pattern of underuse and overuse among lower and higher socioeconomic groups. The impact of rising cesarean delivery rates on neonatal survival is also unclear.Objective: To examine cesarean delivery and its associated socioeconomic patt
Oscillatory neural activity in the cortico-basal ganglia-thalamocortical (CBGTC) loop is associated with the motor state of a subject, but also with the availability of modulatory neurotransmitters. For example, increased low-frequency oscillations in Parkinson’s disease (PD) are related to decreased levels of dopamine and have been proposed as biomarkers to adapt and optimize therapeutic interven
Introduction: Cognitive function is an important outcome measure in patients with brain tumor, providing information about the patient’s clinical situation, treatment effects and possible progressive disease. The aim of this longitudinal study was to evaluate effects of the currently used radiation and chemotherapy treatment on cognitive function and to investigate associations between cognitive f
Massive MIMO is a promising technology to connect very large numbers of energy constrained nodes, as it offers both extensive spatial multiplexing and large array gain. A challenge resides in partitioning the many nodes in groups that can communicate simultaneously such that the mutual interference is minimized. We here propose node partitioning strategies that do not require full channel state in
Mammalian dihydroorotate dehydrogenase, the fourth enzyme of pyrimidine de novo synthesis is an integral protein of the inner mitochondrial membrane that faces the intermembrane space and is functionally connected to the respiratory chain via ubiquinone. Here, we describe the first cloning and analyzing of the complete cDNA of mouse dihydroorotate dehydrogenase. Based on our recent functional expr
