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Alcohol Intake and Cardiovascular Outcomes in Patients With Atrial Fibrillation : RE-LY AF Registry Analysis

Background: Alcohol intake increases recurrence of atrial fibrillation (AF), but its relationship with cardiovascular outcomes is less well characterized. We aimed to study the association between different levels of alcohol intake and cardiovascular outcomes in a global cohort of patients with AF. Methods: This is a cross-sectional analysis of the RE-LY AF registry, including 15,400 patients with

Hippocampal and amygdala subfield volumes in obsessive–compulsive disorder by medication status

Background: Although it has been suggested that the hippocampus and amygdala (HA) are involved in the neurobiology of obsessive– compulsive disorder (OCD), volumetric findings have been inconsistent, and little work has been undertaken on the volumetry of the heterogeneous anatomic units of HA, with their specific functions and cytoarchitecture, in OCD. We sought to explore potential sources of he

Exposome project for health and occupational research night shift cohort (EPHOR-NIGHT) : a unique resource to advance research on night shift work and chronic disease

Purpose The EPHOR-NIGHT cohort was established to investigate how night shift work influences biological pathways and chronic disease risk using a comprehensive working-life exposome approach, focusing on cardiometabolic, mental health, cognitive and biological ageing outcomes. Participant The cohort includes 937 workers aged 20–65 years (88%female), primarily from the healthcare sector (96%) in S

Activity of cefepime/enmetazobactam against highly multidrug-resistant bacterial isolates recovered from war-associated wounds in Ukraine

Background: Escalating resistance among Gram-negative pathogens limits β-lactam options. Cefepime/enmetazobactam combines a fourth-generation cephalosporin with a class A β-lactamase inhibitor. We evaluated its activity against multidrug, extensive and pandrug-resistant war-wound isolates from Ukraine.Materials and methods: We tested 215 clinical samples (2022-2023) isolated from wounded patients

Context Committing Security of Leveled Leakage-Resilient AEAD

During recent years, research on authenticated encryption has been thriving through two highly active and practice-motivated research directions: provably secure leakage-resilience schemes and key- or context-commitment security. However, the intersection of both fields had been overlooked until very recently. In ToSC 1/2024, Struck and Weish\"aupl studied generic compositions of Encryption scheme

The natural menstrual cycle revisited – can natural cycle be trusted

Background: The serum progesterone (P4) level during the luteal phase (LP) plays a crucial role in the initiation and maintenance of pregnancy. However, it is unclear whether the natural cycle consistently provides the best endocrine profile and whether mid-luteal serum P4 levels are always sufficient to support implantation and early pregnancy. The question has become more relevant in relation to

Vegetation resistance to increasing aridity when crossing thresholds depends on local environmental conditions in global drylands

The crossing of aridity thresholds triggers abrupt changes in multiple functional and structural ecosystem attributes across global drylands. While we understand the consequences associated with aridity thresholds, the key factors influencing dryland vegetation resistance when crossing them remain unclear. Here, we used field observations from 58 dryland sites across five continents and satellite

Association of MAFLD and MASLD with all-cause and cause-specific dementia : a prospective cohort study

Background: Liver disease and dementia are both highly prevalent and share common pathological mechanisms. We aimed to investigate the associations between metabolic dysfunction-associated fatty liver disease (MAFLD), metabolic dysfunction-associated steatotic liver disease (MASLD) and the risk of all-cause and cause-specific dementia. Methods: We conducted a prospective study with 403,506 partici

Inverse association between Paleolithic Diet Fraction and mortality and incidence of cardiometabolic disease in the prospective Malmö Diet and Cancer Study

Purpose: Paleolithic Diet Fraction (PDF) estimates how large a portion of the absolute dietary intake stems from food groups included in the Paleolithic diet. In randomized controlled trials higher PDFs have been associated with healthier levels of cardiometabolic risk markers. Our aim was to build upon these findings by examining associations between PDF and mortality and incidence of cardiometab

A FRIENDLY APPROACH TO COMPLEX ANALYSIS : 2nd edition

The book constitutes a basic, concise, yet rigorous first course in complex analysis, for undergraduate students who have studied multivariable calculus and linear algebra. The textbook should be particularly useful for students of joint programmes with mathematics, as well as engineering students seeking rigour. The aim of the book is to cover the bare bones of the subject with minimal prerequisi

Relationships Between Land Use and Terrestrial Organic Matter Transfer to the Baltic Sea Over the Last 500 Years

Terrestrial organic matter (OM) plays a key role in coastal organic carbon burial. However, few studies focus on the relationship between land use in the watershed and the transport of terrestrial OM to coasts from a long-term perspective. In this study, we compared terrestrial OM deposition between an inlet of the Baltic Sea and an upstream lake within the same watershed over the last 500 years,

Different types of meteorological drought and their impact on agriculture in Central China

Challenges in drought monitoring hinder social development. In this study, a robust drought monitoring framework composed of ten indicators was established based on the standard precipitation actual evapotranspiration (SPAEI) index calculated using the maximum entropy production (MEP) model. Additionally, the relationship between meteorological drought and agricultural development was analyzed. Th

Recurrent implantation failure and inflammatory markers in serum and follicle fluid of women undergoing assisted reproduction

It has been shown previously that the immune system plays a role in implantation and embryo development. The objective was therefore to evaluate cytokine levels and Th1/Th2 ratio in women with recurrent implantation failure in this nested case-control study. Women with no implantation after ≥ 3 embryo transfers were included in the recurrent implantation failure group (n = 29) and were compared wi

Operator gender differences in major mechanical complications after central line insertions : a subgroup analysis of a prospective multicentre cohort study

BACKGROUND: A previous study on mechanical complications after central venous catheterisation demonstrated differences in complication rates between male and female operators. The objective of this subgroup analysis was to further investigate these differences. The hypothesis was that differences in distribution of predefined variables between operator genders could be identified.METHODS: This was

A varved lake sediment record of the 10Be solar activity proxy for the Lateglacial-Holocene transition

Solar modulated variations in cosmogenic radionuclide production provide both information on past changes in the activity of the Sun and a global synchronization tool. However, to date the use of cosmogenic radionuclides for these applications is almost exclusively based on 10Be records from ice cores and 14C time-series from tree rings, all including archive-specific limitations. We present the f

Two phase ii randomized trials on the CRTh2 antagonist AZD1981 in adults with asthma

Background: Chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cell (CRTh2) receptor antagonists is being investigated for asthma. Objectives: The aim of this study was to assess the effects of the CRTh2 receptor antagonist, AZD1981 (with/without inhaled corticosteroids [ICSs]), on lung function and asthma control. Patients and methods: Adults aged 18–60 years were enr

A new high-resolution Holocene tephra stratigraphy in eastern Iceland : Improving the Icelandic and North Atlantic tephrochronology

A new and improved Holocene tephra stratigraphy and tephrochronological framework for eastern and northern Iceland is presented. Investigations of a sediment sequence from Lake Lögurinn have revealed a comprehensive tephra record spanning the last 10.200 years. A total of 157 tephra layers have been identified, whereof 149 tephra layers have been correlated to its source volcanic system using geoc