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BACKGROUND: Meal-induced metabolic changes trigger an acute inflammatory response, contributing to chronic inflammation and associated diseases. OBJECTIVES: We aimed to characterize variability in postprandial inflammatory responses using traditional (IL-6) and novel [glycoprotein acetylation (GlycA)] biomarkers of inflammation and dissect their biological determinants with a focus on postprandial

Rationale: Evidence suggests that continuous positive airway pressure (CPAP) treatment promotes weight gain in patients with obstructive sleep apnea (OSA). It is unclear whether weight gain is influenced by CPAP adherence or comorbid disorders. Objectives: To examine the CPAP effects on body mass index (BMI) and local adiposity and the potential moderators of CPAP effects on BMI in patients with O

OBJECTIVE: Topical negative pressure therapy has excellent healing effects in poststernotomy mediastinitis. Topical negative pressure therapy reduces bacterial counts, increases wound edge microvascular blood flow and granulation tissue formation, and facilitates healing. No study has yet been performed to examine the effect of topical negative pressure on the blood and fluid content in the sterna

Problem description: The case company, a packaging company in Lund, Sweden, operates in an industry where high productivity is becoming increasingly crucial to remain the industry leader. One of the most rapidly growing automating technologies today is RPA. The case company has adopted this technology. As of now the case company uses a centralized approach in implementing RPA which means that the

The parts concerning victims of prostitution and the victims of trafficking in two Swedish Government Official Reports are in this essay compared to evoke the differences between the perception of the crimes and it’s victims. The method of the analysis is principally focused on the content and finds traction with a subsequent comparison to discover differences and similarities. The theory is based

Peatlands are vital ecosystems that regulate global carbon storage and hydrology, driven by waterlogged conditions that foster organic matter accumulation. However, disentangling the interactions between climate, hydrology, and tree growth in peatlands remains challenging. To investigate these relationships, we developed a 117-year ring width (RW) chronology (1902–2019) and complementary intra-ann

The lifelong risk of stroke following adverse pregnancy outcomes, and potential causality, are unknown. This study examined five major adverse pregnancy outcomes and long-term risk of stroke in a large population-based cohort. Methods A national cohort study was conducted of all 2 201 393 women with a singleton delivery in Sweden during 1973–2015, followed up for stroke through 2018. Cox regressio

Childhood stunting is a serious global public health issue that exhibits local spatial variations. Previous studies have used traditional statistical methods to identify stunting risk factors, and little is known about the application and usefulness of spatial machine learning techniques in identifying localized stunting risk factors based on complex datasets. This study assesses the performance o

Environmental changes over time and across different regions profoundly affect agriculture, forestry, water management, public health, and ecosystems. Therefore, monitoring these fluctuations is crucial for informing decision-making and developing strategies for long-term sustainability. While ground-based methods provide valuable insights into environmental dynamics, they are inherently limited i

Genom projektet har vi har strukturerat ett digitalt vårdförlopp som inte bara förbättrar tillgängligheten och flexibiliteten för patienter i palliativ vård, utan även ger närstående ett bättre stöd och underlättar kommunikationen med vården. Projektet syftar till att införa fler digitala vårdlösningar i den palliativa öppenvården genom 1177.se-plattformen, och därmed stärka vårdens strategiska må

ObjectiveSputum cultures can guide antibiotic therapy, particularly in severe pneumonia or when resistant pathogens are suspected. However, data on how prior and ongoing antibiotic exposure affects microbial detection are limited. This study aimed to evaluate this impact, stratified by timing and route of administration.MethodsIn- and outpatients from nine hospitals in Skåne, Sweden, who submitted

Accurate prediction of spatial yield variations within individual fields is crucial for precision agriculture, as it enables optimized resource allocation and targeted crop management. In this study, we propose a novel framework that leverages remote sensing data and Graph Attention Networks (GATv2) to predict fine-scale yield variations for winter wheat at a high resolution (10 m × 10 m). The obj

Background: Management of traumatic spinal cord injury is complex and depends on a multidisciplinary approach involving pre-hospital services, spinal surgery, intensive care unit treatment and specialized rehabilitation. International clinical practice guidelines for the handling of these patients offer specific recommendations regarding transportation, radiological investigations, timing of surge

Small area childhood stunting risk estimations remain a critical tool for shaping the surveillance policies of such a public health concern. With classical statistical methods, stunting risk metrics are mainly reported at a national level, which inhibits fine-scale insights at a more localized level. To this end, we implemented a novel multilevel small area estimation (SAE) approach for effectivel

Background: We set out to profile the immune mechanisms active in treatment-naïve oligoarticular JIA (oJIA) to improve the knowledge of its immunopathogenesis, to identify potential biomarkers that can aid diagnosis, predictions and that correlate with clinical disease parameters. Methods: Using Olink proteomics (inflammation panel measuring 92 markers), we defined and compared the inflammation pr