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IDO1 can be induced by interferon gamma (IFN-γ) in multiple cell types. We have earlier described that the DNA methyltransferase inhibitor zebularine also induces IDO1 in several rat cell clones. We now describe a synergistic induction of IDO1 expression by IFN-γ and zebularine. To elucidate the mechanism of the IDO1 induction we have studied the methylation status in the promoter region of the ID
OBJECTIVES:: To compare the plasma volume (PV) expanding effect of a fast infusion rate with that of a slow infusion rate of a fixed volume of 5% albumin, of the synthetic colloids, 6% hydroxyethyl starch 130/0.4 and 4% gelatin, and of 0.9% NaCl in a rat sepsis model and to compare the plasma-expanding effect among these fluids. DESIGN:: Prospective, randomized animal study. SETTING:: University h
Results are presented of a search for any particle(s) decaying to six or more jets in association with missing transverse momentum. The search is performed using 1.34 fb(-1) of root s = 7TeV proton-proton collisions recorded by the ATLAS detector during 2011. Data-driven techniques are used to determine the backgrounds in kinematic regions that require at least six, seven or eight jets, well beyon
A search is presented for production of dark-matter particles recoiling against a leptonically decaying Z boson in 20.3 fb(-1) of pp collisions at root s = 8 TeV with the ATLAS detector at the Large Hadron Collider. Events with large missing transverse momentum and two oppositely charged electrons or muons consistent with the decay of a Z boson are analyzed. No excess above the Standard Model pred
IL-5 is a Th2 cytokine which activates eosinophils and is suggested to have an atheroprotective role. Genetic variants in the IL5 locus have been associated with increased risk of CAD and ischemic stroke. In this study we aimed to identify genetic variants associated with IL-5 concentrations and apply a Mendelian randomisation approach to assess IL-5 levels for causal effect on intima-media thickn
Purpose: This work examined the feasibility of flattening filter free (FFF) volumetric modulated arc therapy (VMAT) for extreme hypofractionation of prostate cancer. The aim was to investigate the potential gain in treatment time per fraction for extreme hypofractionation of prostate cancer, while preserving or improving the treatment plan quality and radiation delivery quality. The impact of intr
Inledning Tjänstefelsbestämmelsen återfinns i 20:1 BrB och har diskuterats kriminalpolitiskt under lång tid, vilket medfört att tjänstefelsansvarets stränghet varierat. Frågeställningen blir då vilka argument som framförts för och mot kriminalisering av tjänstefelsgärningar och vilka kriminaliseringsbegränsande principer som kan anföras för och mot kriminalisering av tjänstefelsgärningar. Syftet mIntroduction The misconduct provision is found in 20:1 in the Penal Code and has been discussed in criminal policy for a long time, resulting in that the severity of the misconduct responsibility has varied. The question that follows is what arguments that are presented for and against the criminalization of misconduct offences and which criminalization limiting principles that can be set in contr
This study examines whether the right to respect for private and family life, as enshrined in Article 8 of the European Convention of Human Rights, is equally enjoyed by transgender people. The focus of the research is on the European Court of Human Rights’ case law on gender identity, and special emphasis is placed on the principles of equality and non-discrimination. For the analysis, the Europ
Thesis purpose: The purpose of this study is to investigate the interdependencies within the process of partner selection in the fashion and design sector and the emanating criteria for finding the ideal co-branding partner in order to use co-branding as a strategic brand activation tool. Methodology: Multiple Case Study Theoretical perspective: Brand Building and Brand Activation, Relationship Ma
Urbanization has led to significant infrastructural challenges, particularly in the slum areas of the Global South. Nature-based Solutions (NbS) are emerging as innovative approaches to enhance urban sustainability and resilience. This study investigates the enabling environment for decentralized governance in implementing NbS within urban slums, focusing on case studies in Indonesia and the Phili
The present thesis sought to inspect the yet-unexplored digital dimension of North Korean human rights activism, aiming to uncover the strategic digital communication wielded by a selected case study. The research was thus based on an explorative qualitative inquiry of the social media activity of Park Yeonmi, one of the most renowned North Korean defectoractivists in the West. A total of 90 eleme
Canals have always been an important part of The Netherlands and played a big role within the urban development of the cities. As many of the canals lost their functions by the 19th century, a lot were replaced with streets infrastructure. Replacing the canals with streets has affected the overall ambience of many neighbourhoods in The Netherlands. The elimination of the water element caused many
Extractivist projects are causing widespread socio-ecological destruction across Indonesia, impacting ecosystems, rural communities, and Indigenous ways of life. At the forefronts of socio-ecological collapse, women are increasingly taking up leadership roles in environmental activism. Simultaneously, women environmental defenders (WEDs) are experiencing a growing crisis of violent repression. Thi
Chronic respiratory diseases (CRDs) are a group of incurable conditions, among which the most common, such as COPD and asthma, have significant negative impacts on patients’ mental health and economic productivity. Understanding of the causes and affected populations of CRDs is continuously evolving, with air pollution now recognized as an important etiological factor alongside smoking, receiving
This thesis explores how Swedish civil society organisations (CSOs) navigate transnational partnerships under civic space restrictions in India. Against the backdrop of the Foreign Contribution (Regulation) Act (FCRA) and shrinking Swedish aid, the study analyses how CSOs adapt to legal, political, and relational constraints. Drawing on four semi-structured interviews and guided by the concepts of
With Artificial Intelligence (AI) relying heavily on vast datasets, including publicly available personal online data and increasing amounts of fines for data breaches the individuals demand for control over personal data increases. The purpose of this thesis is to analyze the efficacy of the GDPR in granting data subjects control over their personal data when they are used to train AI. Therefore,
