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It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. Study-specific results were combined using meta-analysis (88,383 individuals of European descent, including 7,292 with AF). Variants with nominal i
Aims: ST-depression at 24hECG has not been studied in relation to atrial fibrillation (AF) risk. We aimed to determine whether ST-depression at 24hECG was associated with incident AF in two Swedish population-based cohorts - a sub-cohort of the Malmö Diet and Cancer study (MDCS), and the cohort 'Men born in 1914', and to determine whether 24hECG could be used to predict AF development.Methods and
The field of mass evacuation has existed for a long time. Already during the Roman Empire era evacuation problematic was considered. In modern times the field has gained more attention during the last couple of decades, especially for sports grounds and stadiums. Through analysis of some well-known historical crowd disasters and through a literature survey the aim has been to compile the most impo
Det råder idag en trend att förtäta, det vill säga bygga tätt i städer istället för att låta städer växa utåt. Det finns många fördelar med att förtäta då en tät stad ger underlag för bättre service och tätare kollektivtrafik vilket därmed kan leda till mer hållbara städer. Men det finns också nackdelar med att bygga tätt. Genom att förtäta städer samlas fler människor på mindre ytor och därmed ocToday it has become a trend to densify cities instead of allowing them to grow outwards. Densification has many advantages, a dense city provides a basis for better service and denser public transport, which can lead to more sustainable cities. However, building dense also has its disadvantages. By densifying cities, more people gather on a smaller area. This result in more children on a smaller a
This study examines how national healthcare initiatives focused on person-centered care are put into practice within Sweden's healthcare system. It analyses how these national policies are represented and implemented in accreditation documents across six Swedish regions—Skåne, Västra Götaland, Jönköping, Halland, Kronoberg, and Östergötland. The research uses qualitative document analysis to e
BACKGROUND: Fever is associated with brain injury after cardiac arrest. It is unknown whether fever management with a feedback-controlled device impacts patient-centered outcomes in cardiac arrest patients. This trial aims to investigate fever management with or without a temperature control device after out-of-hospital cardiac arrest. METHODS: The TEMP-CARE trial is part of the 2 × 2 × 2 factoria
BACKGROUND: Head impacts are common in contact sports such as boxing and occur at times of elevated core body and brain temperatures induced by the exercise. Following impact, elevated brain temperature may lead to the development of exacerbated brain injury that can be monitored by blood biomarkers. Blood-brain biomarkers S100B and glial fibrillary acidic protein (GFAP) reflect glial injury; neur
Multi-wavelength thermo-optical analysis (MW-TOA) and Raman spectroscopy are commonly used methods to study soot sampled on filters, in terms of carbon content, nanostructure, and absorption properties. In this work, these techniques were combined to study how these characteristic properties of soot change in premixed flames, 1) at various flame heights during soot maturation and 2) as a result of
The growing complexity of urban energy systems, climate uncertainties, and geopolitical disruptions highlight the need for energy flexibility and smart management. Recent developments in smart buildings enable real-time adaptability and collective energy behavior through the deployment of Reinforcement Learning (RL), which optimizes energy use, integrates distributed resources, and enhances demand
Carbon Black (CB), graphene, and nanodiamonds represent three classes of manufactured carbonaceous nanoparticles consisting almost exclusively of insoluble material. Particle-related Reactive Oxygen Species (ROS) have been linked to in vivo and in vitro toxicity and determining particle ROS activity is an efficient way of estimating nanomaterial toxicity and assist in the safe-by-design developmen
OBJECTIVES: Evidence on waning patterns in protection from vaccine-induced, infection-induced, and hybrid immunity against death is scarce. The aim of this study is to assess the temporal trends in protection against mortality.METHODS: Population-based case-control study nested in the total population of Scania Region, Sweden using individual-level registry data of COVID-19-related deaths (<30 day
The COVID-19 pandemic caught the world largely unprepared, including scientific and policy communities. On April 10-13, 2022, researchers across academia, industry, government, and nonprofit organizations met at the Keystone symposium "Lessons from the Pandemic: Responding to Emerging Zoonotic Viral Diseases" to discuss the successes and challenges of the COVID-19 pandemic and what lessons can be
Venues:Wilminktheater en Muziekcentrum Enschede / Tivoli Vredenburg / Het Concertgebouw Amsterdam / Elbphilharmonie / Festhalle Viersen / Alte Oper Frankfurt / Amare / Muziekgebouw aan't IJ Amsterdam AmsterdamProgramme:Georg Philipp Telemann: Konzert für Violine, Violoncello, Trompete und Streicher in D-Dur, TWV 53:D5Ludwig van Beethoven: Streichquartett Nr. 15 a-Moll op. 132, "Heiliger Dankgesang
α-Synuclein is a synaptic protein that accumulates primarily in synucleinopathies and secondarily in certain lysosomal storage disorders. However, its physiological roles in health and disease are not fully understood. In part, this has been hampered by the inability to visualize α-synuclein and its cellular localization, due to the lack of specific antibodies and faithful reporters. Here, we used
Oppositely charged polymer-surfactant systems are expected to interact with formation of coacervate complexes near composition of charge-neutrality. Such behaviour is widely used in formulated products (e.g. household and personal care), where the co-deposition of coacervates and active ingredients on various surfaces is triggered by dilution. A transition towards the use of more sustainable ingre
This study explores the coating of photocatalytic nanoparticles with antimicrobial peptides (AMPs) for boosted antimicrobial effects, and how such effects depend on AMP properties. For this, TiO2 nanoparticles are coated with the AMP KYE21 or its hydrophobically enhanced variant WWWKYE21. Mirroring effects of free peptides, coated nanoparticles displayed higher binding and UV-induced degradation f
Alexander disease (AxD) is a rare and severe neurodegenerative disorder caused by mutations in glial fibrillary acidic protein (GFAP). While the exact disease mechanism remains unknown, previous studies suggest that mutant GFAP influences many cellular processes, including cytoskeleton stability, mechanosensing, metabolism, and proteasome function. While most studies have primarily focused on GFAP
In this study, we report the degradation of smooth and rough lipopolysaccharides (LPS) from Gram-negative bacteria and of lipoteichoic acid (LTA) from Gram-positive bacteria by peptide-coated TiO2 nanoparticles (TiO2 NPs). While bare TiO2 NPs displayed minor binding to both LPS and LTA, coating TiO2 NPs with the antimicrobial peptide LL-37 dramatically increased the level of binding to both LPS an
SignificanceThe spatial distribution of the photosensitizing drug concentration is an important parameter for predicting the photodynamic therapy (PDT) outcome. Current diffuse fluorescence tomography methods lack accuracy in quantifying drug concentration. The development of accurate methods for monitoring the temporal evolution of the drug distribution in tissue can advance the real-time light d
Microsoft Word - PM examensarbetare GEOR01 och GEOR02 september 2015 PM examensarbete geologi GEOR02 september 2015 PM angående genomförande och examination av examensarbeten på avancerad nivå i geologi (GEOR01 och GEOR02) Examensarbetets genomförande Examensarbetsuppgift kan väljas med utgångspunkt från förslagslista upprättad av studierektor. I denna finns en kort projektbeskrivning samt handle
https://www.geologi.lu.se/sites/geologi.lu.se/files/pm_examensarbetare_geor01_och_geor02_september_2015_v2_ac.pdf - 2026-07-22
