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Development of a Multiparametric Voxel-Based Magnetic Resonance Imaging Biomarker for Early Cancer Therapeutic Response Assessment.

Quantitative magnetic resonance imaging (MRI)-based biomarkers, which capture physiological and functional tumor processes, were evaluated as imaging surrogates of early tumor response following chemoradiotherapy in glioma patients. A multiparametric extension of a voxel-based analysis, referred as the parametric response map (PRM), was applied to quantitative MRI maps to test the predictive poten

Avian neural crest cell migration is diversely regulated by the two major hyaluronan-binding proteoglycans PG-M/versican and aggrecan

It has been proposed that hyaluronan-binding proteoglycans play an important role as guiding cues during neural crest (NC) cell migration, but their precise function has not been elucidated. In this study, we examine the distribution, structure and putative role of the two major hyaluronan-binding proteoglycans, PG-M/versicans and aggrecan, during the course of avian NC development. PG-M/versicans

Formation of the bicoid morphogen gradient: an mRNA gradient dictates the protein gradient

The Bicoid (Bcd) protein gradient is generally believed to be established in pre-blastoderm Drosophila embryos by the diffusion of Bcd protein after translation of maternal mRNA, which serves as a strictly localized source of Bcd at the anterior pole. However, we previously published evidence that the Bcd gradient is preceded by a bcd mRNA gradient. Here, we have revisited and extended this observ

Milk Genomics – Impact of Genetic Polymorphism on Bovine Milk Composition and Processability

Popular Abstract in Swedish Ny kunskap gör det möjligt att med hjälp av DNA-information välja ut vilka kvigor/kor som förväntas ge en hög mjölkavkastning, höga halter av mjölkens komponenter och optimala egenskaper för ostproduktion. Denna information kan användas för att bättre anpassa mjölkens sammansättning och processegenskaper med de svenska mejeriernas behov för att på så vis förbättra mjölkMilk genomics is a new area of research that explores the relations between cow genetics and milk characteristics. Identifying the genes controlling compositional and technological traits of milk will give opportunities to select cows for targeted milk production. In this thesis, the impact of different genetic approaches, i.e. quantitative genetic evaluation, single gene effects and genomic selec

Rhinomanometry in clinical use. A tool in the septoplasty decision making process.

Popular Abstract in Undetermined Populärvetenskaplig sammanfattning på svenska Nästäppa, som betyder svårigheter att andas med näsan är ett vanligt symtom i befolkningen, och en vanlig orsak till att patienter söker vård. Kronisk nästäppa är ett frekvent symtom (ca 40 % av vuxna) som ofta medför mun-andning med torra slemhinnor i munhåla och svalg samt snarkning till följd. Nässkiljeväggen, septSubjective nasal obstruction is a common chronic complaint caused by mucosal disease, skeletal abnormality or a combination of both. The challenge is to determine the main cause and to decide whether the intervention should be medical or surgical. Diagnosis is done by a combination of rhinoscopy, subjective and objective assessments of nasal obstruction. Rhinomanometry measures the nasal airway re

Kartläggning av ingående materialflöde till UMAS med avseende på risker och riskhantering: en fallstudie av fyra flödeskedjor

Today’s hospitals in Sweden are all dependent of large networks of suppliers of medical supplies. These consist of many supply chains that are regularly exposed to both external and internal risks. One hospital affected by these risks is UMAS (Malmö University Hospital). UMAS is dependent on its supply chains to work without disruptions but it is unclear what risks they might be exposed to and how

Extremt för tidigt född - hur är livet som vuxen?

Syftet med denna kvantitativa studie var att följa upp extremt för tidigt födda (före vecka 29) när de nått vuxen ålder. De extremt för tidigt födda jämfördes med en kontrollgrupp bestående av jämnåriga födda i fullgången tid. Deltagarna i studien hämtades från en uppföljningsstudie av extremt för tidigt födda som tidigare följts upp vid 10 och 18 års ålder. Deltagarna var vid tiden för studien 27The aim of this quantitative study was to follow up children born extremely preterm (before week 29) in adulthood. The group of extremely preterm adults was compared to peers born at term. The extremely preterm and the control group have previously been followed up at ages 10 and 18. At the time of this study the participants were 27-28 years old. Questionnaires were sent to the two groups and 77

Shifting Horizons: The Evolving Geography of Uzbek Labor Migration to the European Union

This paper explores recent trends in Uzbek labor migration, with a focus on the growing role of the European Union as a destination. While Russia remains the largest host country, ongoing diversification has led to a notable increase in migration to EU member states, particularly for employment. Drawing on official statistics and fieldwork, the study highlights rising numbers of Uzbek migrants in

Preterm birth, low fetal growth and risk of suicide in adulthood : A national cohort and co-sibling study

Background: Adverse perinatal exposures have been associated with psychiatric disorders and suicidal behaviours later in life. However, the independent associations of gestational age at birth or fetal growth with suicide death, potential sex-specific differences, and causality of these associations are unclear. Methods: A national cohort study was conducted of all 2 440 518 singletons born in Swe

KOM MED - kommunicera med teknik : Kursbok

Kursbok om Alternativ och Kompletterande Kommunikation (AKK), med fokus på kommunikationshjälpmedel, praktiska metoder och förhållningssätt. Boken ingår i ett kursmaterial i tre delar, för utbildning av personliga assistenter och andra som arbetar och lever nära ungdomar och vuxna med omfattande kommunikationssvårigheter på grund av funktionsnedsättning.

Preliminary evidence that blocking the uptake of placenta-derived preeclamptic extracellular vesicles protects the vascular endothelium and prevents vasoconstriction

Preeclampsia (PE) is a pregnancy syndrome characterized by hypertension and organ damage manifesting after 20 gestational weeks. The etiology is of multifactorial origin, where placental stress causes increased levels of placenta-derived extracellular vesicles (STBEVs) in the maternal circulation, shown to cause inflammation, endothelial activation, vasoconstriction, and anti-angiogenic activity.