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It is estimated that the number of devices connected to the Internet will be 50 billion by 2020. How should a not-so-tech-savvy end user be able to discover and directly interact with a myriad of connected things in an intuitive and comfortable manner? Up until now, smartphones have shown potential for managing the Internet of Things (IoT) environments, but we cannot rely on that technology. Weara
There is an unmet clinical need for objective biomarkers to monitor disease progression and treatment response in Huntington's disease (HD). The aim of this review is, therefore, to provide practical advice for biomarker discovery and to summarise studies on biofluid markers for HD. A PubMed search was performed to review literature with regard to candidate saliva, urine, blood and cerebrospinal f
By utilizing the promising alternative fuel of syngas, and the syngas/diesel dual-fuel reactivity controlled compression ignition (RCCI) is a potential combustion strategy for internal combustion engines. However, the optimal operating parameters for syngas/diesel RCCI engines under wide operating conditions have not been investigated. In this study, the operating parameters include fuel supply, s
During a meeting held in Trento, Italy in March 2017, and organised by the COST Action CHIP ME (IS1303) to discuss about ELSI of genome-editing, many different positions emerged on the possibility to intervene on reproduction and especially on the human embryo. At the time, the Nuffield Council on Bioethics had commissioned a background paper on genome editing, and the corresponding Working Group
Development of antibody drugs against novel targets and pathways offers great opportunities to improve current cancer treatment. We here describe a phenotypic discovery platform enabling efficient identification of therapeutic antibody-target combinations. The platform utilizes primary patient cells throughout the discovery process and includes methods for differential phage display cell panning,
Assessment of breast density at the point of mammographic examination could lead to optimized breast cancer screening pathways. The onsite breast density information may offer guidance when to recommend supplemental imaging for women in a screening program. In this work, performance evaluation of a new software (Insight BD, Siemens Healthcare GmbH) for fast onsite quantification of volumetric brea
Water security offers to the local population an adequate quality and quantity of water for health, economy, livelihoods and ecosystems. Hence, achieving basic levels of water security should be a priority in areas where access to fresh water is scarce. The Punata alluvial fan (Bolivia) is a semiarid zone and an important agricultural zone, where the main source of water is groundwater. Therefore,
Background: Second malignant neoplasms and cardiotoxicity are among the most serious and frequent adverse health outcomes experienced by childhood and adolescent cancer survivors (CCSs) and contribute significantly to their increased risk of premature mortality. Owing to differences in health-care systems, language and culture across the continent, Europe has had limited success in establishing mu
Background. Arterial spin labeling is an MR imaging technique that measures cerebral blood flow (CBF) noninvasively. The aim of the study is to assess the diagnostic performance of arterial spin labeling (ASL) MR imaging for differentiation between high-grade glioma and low-grade glioma. Methods. Cochrane Library, Embase, Medline, and Web of Science Core Collection were searched. Study selection e
The calls for evidence-based public policy making have increased dramatically in the last decades, and so has the interest in evidence-based sustainability studies. But questions remain about what “evidence” actually means in different contexts and if the concept travels well between different domains of application. Some of the most relevant questions asked by sustainability studies are not, and
Air pollution research has been conducted in Europe and North America as well as in Asia and South America for decades, but there has, so far, only been a limited amount of studies on air pollution and its health effects conducted in Africa. Until recently, global inventories of pollutants from North America Europe and Asia have been used for air quality and climate change modelling in Africa (Bon
With the advent of nationwide mammography screening programmes, a number of natural history models of breast cancers have been developed and used to assess the effects of screening. The first half of this article provides an overview of a class of these models and describes how they can be used to study latent processes of tumour progression from observational data. The second half of the article
The ongoing digitalisation of societies, exacerbated by the COVID-19 pandemic, has led to increased efforts to ensure the digital inclusion of older adults. Digital inclusion strategies throughout the COVID-19 pandemic predominantly focused on increasing access and basic digital literacy of Information and Communication Technologies (ICTs) for all members of society. Older adults, who are more lik
Objectives: To investigate factors associated with multiple induced abortions. Materials and methods: A multi-centre cross-sectional survey among abortion-seeking women (n = 623;14-47y) in Sweden, 2021. ‘Multiple abortions’ was defined as having had ≥2 induced abortions. This group was compared to women with a previous experience of 0-1 induced abortion. Regression analysis was conducted to determ
We train and compare the performance of two different machine learning algorithms to learn changes in winter wheat production for fields from the southwest of Sweden. As input to these algorithms, we use cloud-penetrating Sentinel-1 polarimetry radar data together with respective field topography and local weather over four different years. We note that all of the input data were freely available.
In recent years, global technology-based competition has not only intensified, but become increasingly linked to a more comprehensive type of competition between different political and value systems. The globalist assumptions of the post-Cold War era that reliable mutually beneficial agreements could be reached with all nations, regardless of ideology, have been shattered. A previously less visib
High water consumption in the agricultural sector, population growth, urbanization, and industrialization have gradually turned groundwater into a quantitative and qualitative crisis. This study investigated aquifer storage and recovery (ASR) as the environmental effect of modernization projects in agricultural water distribution systems. For this purpose, a numerical model of the Qazvin Aquifer l
Complex diseases are caused by a combination of genetic, lifestyle, and environmental factors and comprise common noncommunicable diseases, including allergies, cardiovascular disease, and psychiatric and metabolic disorders. More than 25% of Europeans suffer from a complex disease, and together these diseases account for 70% of all deaths. The use of genomic, molecular, or imaging data to develop
