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Gas6 and protein S are two homologous secreted proteins that depend on vitamin K for their execution of a range of biological functions. A discrete subset of these functions is mediated through their binding to and activation of the receptor tyrosine kinases Axl, Sky and Mer. Furthermore, a hallmark of the Gas6-Axl system is the unique ability of Gas6 and protein S to tether their non receptor-bin
Deviations from classical two-state kinetics in protein folding need not always be explained by the presence of rapidly formed intermediates. In some cases, such deviations are caused by short-lived aggregates whereas in other cases they arise from changes of the position of the transition state. These are two new facets of the mechanism of two-state folding. The first part of this account describ
The Sb-V-O, Al-Sb-V-O and Al-Sb-V-W-O systems were investigated for the ammoxidation of propane to acrylonitrile. Compared with pure approximate to SbVO4, the approximate to SbVO4 that was obtained by co-calcination of pure approximate to SbVO4 with alpha-Sb2O4 at 800 degrees C and subsequent sieving was found to be much more selective to acrylonitrile. XRD data showed no variation of the rutile u
The mechanisms behind the long duration of bronchodilating action of the beta 2-adrenoceptor agonists formoterol and salmeterol are only partially understood. This review compares pharmacological characteristics of long-acting versus short-acting beta 2-adrenoceptor agonists in human and animal airways. Based upon the reviewed evidence, it is concluded that for beta 2-adrenoceptor agonists, long d
The compatibility between the implementation of information and communication technologies (ICTs) strategies and the bottom-up approach in the developmental process is assessed. In order to put the theoretical arguments into practice, the existing benefits and obstacles of implementing such strategies in reality are presented. Deriving from the analysis of the bottom-up approach is the identificat
Industrial interventions that focus on increased productivity may impair the ergonomics, on a workstation or individual level. This paper presents a method that characterises work time consumption and physical work load of manual work, using video recordings synchronised with physiological measurements of, e.g. muscular activity, and postures. The underlying idea was that it is possible to amalgam
Background: The aim of this study was to develop and psychometrically test a short, patient-reported questionnaire to be used in clinical practice for patients with Irritable Bowel Syndrome (IBS). The Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS) questionnaire was designed to measure the treatment response of symptoms and well-being in patients suffering from IBS. Methods: The VAS-I
A common control technique for limiting nitrogen oxide emissions is selective catalytic reduction (SCR) of NO, with NH,. The lifetime of the catalyst, which has a critical role in overall SCR system economics, is, however, limited due to deactivation by poisoning. A two-dimensional model was developed to describe poison accumulation and activity of an SCR catalyst. The model that has no adjustable
Regular replacement therapy (prophylaxis) for haemophilia has been shown to prevent development of disabling arthropathy and to provide a better quality of life compared to treatment on demand; however, at a substantially higher cost. Calculations based on pharmacokinetic principles have shown that shortening dose intervals may reduce cost. The aim of this prospective, randomized, crossover pilot
Our aims were to investigate possible associations between hospitalisation for venous thromboembolism (VTE) and socioeconomic and occupational factors. A nationwide database was constructed by linking Swedish census data to the Hospital Discharge Register (1990-2007). Hospital diagnoses of VTE were based on the International Classification of Diseases. Standardised incidence ratios were calculated
To evaluate construct validity, internal consistency and inter-rater reliability of the Posture and Postural Ability Scale for children with cerebral palsy.
This paper presents an innovative research on urban risk reduction and climate change adaptation that combines case studies, grounded theory and systems analysis, which could be used as a template for similar intersectoral and interdisciplinary investigations. Such a ‘case studies–grounded theory–systems analysis approach’ permits a grounded theory to be built from case study data, which is viewed
Given an electronic wave function, generated by the MCHF program (LS format) or the MCHF_CI program (LSJ format), this program computes the hyperfine interaction constants, A(J) and B(J). In strong experimental magnetic fields, the splitting is also affected by the off-diagonal hyperfine constants A(J,J-1), B(J,J-1), and B(J,J-2) and these are computed as well, depending on the input data.
