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Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic characterization of circulating proteins across different stages of HF may provide pathophysiological insights and identify therapeutic targets. Here we report application of aptamer-based proteomics to identify proteins associated with prospective HF i

Myelodysplastic/myeloproliferative neoplasms, unclassifiable (MDS/MPN-U) are rare genetically heterogeneous hematologic diseases associated with older age and a poor prognosis. If the disease progresses into acute myeloid leukemia (AML), it is often refractory to treatment. To gain insight into genetic alterations associated with disease progression, whole exome sequencing and single nucleotide po

On-demand droplet generation from a continuously flowing stream of aqueous phase has profound applications in dropletbased microfluidics for rare event encapsulation studies. Here, we present acoustic relocation-based droplet generation from co-flowing immiscible fluids in an on-demand manner using bulk acoustic wave (BAW). After on-demand droplet generation, droplets are isolated using the same a

Frontotemporal dementia (FTD) is the second most prevalent type of early-onset dementia and up to 40% of cases are familial forms. One of the genes mutated in patients is CHMP2B, which encodes a protein found in a complex important for maturation of late endosomes, an essential process for recycling membrane proteins through the endolysosomal system. Here, we have generated a CHMP2B-mutated human

BackgroundA specific eHealth device, a surf tablet, was developed for bridging between advanced in-hospital care and children’s homes. Since little is known about determinators for parental eHealth usage, the study’s aim was to explore if parents’ usage of the device was associated with their eHealth literacy, or their satisfaction with their child’s healthcare or with the specific surf tablet.Met

Background Preeclampsia is considered a major cause of maternal and fetal morbidity and mortality. The aim of the present case-control study in Sweden was to assess the hypothesized association between low serum vitamin D concentrations in early pregnancy and the risk of developing preeclampsia since vitamin D may play a role in early placental development. Methods The study included 296 women dia

Faithful modeling of tissues and organs requires the development of systems reflecting their dynamic 3D cellular architecture and organization. Current technologies suffer from a lack of design flexibility and complex prototyping, preventing their broad adoption by the scientific community. To make 3D cell culture more available and adaptable we here describe the use of the fused deposition modeli

Pain, use of painkillers and alcohol are highly prevalent in the general population. Aims of the study were to describe differences in pain, alcohol consumption and use of painkillers among two 60 year old birth cohorts stratified by gender. Participants were recruited from the Skåne centre of The Swedish National study on Aging and Care, a multicentre, prospective, longitudinal study. The sample

The development of cancer is driven by the accumulation of many oncogenesis-related genetic alterations and tumorigenesis is triggered by complex networks of involved genes rather than independent actions. To explore the epistasis existing among oncogenesis-related genes in lung cancer development, we conducted pairwise genetic interaction analyses among 35,031 SNPs from 2027 oncogenesis-related g

There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The analysis included 476,160 participants, recruite

Diamond-Blackfan anemia (DBA) is a bone marrow failure syndrome caused by mutations in ribosomal protein genes. Pathogenic mechanisms are poorly understood but involve severely reduced proliferation of erythroid precursors. Because current DBA therapies are ineffective and associated with severe side effects, disease-specific therapies are urgently needed. We hypothesized that druggable molecular

Purpose To investigate multivoxel proton Magnetic Resonance Spectroscopy (1HMRS) biometrics for preoperative differentiation and prognosis of patients with brain metastases (MET), low-(LGG) and high grade glioma (HGG). Methods Thirty-five patients (15 HGG, 9 LGG and 11 MET) were included. Proton Magnetic Resonance Spectroscopy Imaging(1H-MRSI) data was assessed and neurochemical profiles for metab

Background Metastatic melanoma is still one of the most prevalent skin cancers, which upon progression has neither a prognostic marker nor a specific and lasting treatment. Proteomic analysis is a versatile approach with high throughput data and results that can be used for characterizing tissue samples. However, such analysis is hampered by the complexity of the disease, heterogeneity of patients

Background: Survivors of childhood cancer are at increased risk for a wide range of late effects. However, no large population-based studies have included the whole range of somatic diagnoses including subgroup diagnoses and all main types of childhood cancers. Therefore, we aimed to provide the most detailed overview of the long-term risk of hospitalisation in survivors of childhood cancer. Metho

Enligt artikel 1 i den Europeiska konventionen för de mänskliga rättigheterna och de grundläggande friheterna (EKMR) måste de fördragsslutande staterna inom ramen för sin jurisdiktion garantera konventionens fri- och rättigheter. Denna skyldighet är främst territoriell, men i exceptionella fall medges vissa undantag. Uppsatsen behandlar dessa undantag såsom de utvecklats i Europadomstolens praxis According to Article 1 of the European Convention on Human Rights and Fundamental Freedoms (ECHR) the contracting parties must secure the conventional rights within their jurisdiction. The obligation is primarily territorial but in exceptional cases it can be extended to apply extraterritorially. This paper will investigate the development of the case law of the European Court of Human Rights (the

Under metoo-hösten år 2017 publicerade pressen namn på flera kända män som blivit anklagade för olika typer av sexualbrott. En av dessa män var stjärnjournalisten Fredrik Virtanen som från en dag till en annan pekades ut som våldtäktsman i Sveriges största tidningar. Pressen publicerade namn och detaljer om anklagelserna, trots att anklagelserna grundades på bristfällig bevisning. Hur kunde detta

The aim of this study was to use multi-radionuclide autoradiography to compare the different distributions of three radiolabelled tracers in an atherosclerotic mouse model. This method, along with immunohistochemistry, was applied to investigate the intra-aortic distribution of 2-deoxy-2-[(18)F]fluoro-D-glucose ((18)F-FDG), (131)I/(125)I labeled anti-oxidized Low Density Lipoprotein (oxLDL), and n

Abstract Uppsatsen Fienden Inifrån granskar medierapporteringen kring Anders Breivik – gärningsmannen bakom terrordåden i Oslo den 22 juli 2011 med syftet att nå djupare insikt i hur media konstruerar fienden när denne kommer inifrån det egna samhället, samt vilka konsekvenser denna konstruktion får. Genom att undersöka 16 artiklar publicerade i Dagens Nyheter analyseras mediekonstruktionen av fi

The Swiss foreign policy offers a deviant case. Most countries that were neutral during the Cold War have during the last decades become more cooperative, while Switzerland on the other hand still contains a rather stable foreign policy. Because traditional theories in International Politics offer no concrete explanation to this puzzle, I have been oriented towards decision-making theories in dome

Ändtarmscancer är en av de vanligast förekommande cancersjukdomarna. Tillsammans med tjocktarmscancer är det den tredje vanligaste cancersjukdomen i världen. Den behandlas vanligen med kirurgi, under vilken en stor del av ändtarmen och dess omgivande fettvävnad tas bort. För att minska risken för återfall kan operationen kompletteras med strålbehandling, där patienterna oftast strålbehandlas innanBackground and purpose: During radiotherapy, rectal cancer patients show inter-fractional internal motion that effects the delivered dose distribution. The purpose of this work is to study I) the inter-fractional bladder volume change, II) the effect of bladder volume change on bowel dose distribution, III) the effect of bladder optimization on the relationship between bladder volume and bowel dos