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The transcription factor STAT3 is a potential target for the treatment of castration-resistant prostate cancer. Galiellalactone (1), a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes. In this study we characterized 6 (GPA512, Johansson, M.; Sterner, O. Patent WO 2015/132396 A1, 2015), a prodrug of 1. In vitro studies showed that 6 is rapidly converted to 1 in plasma

Many microfluidic devices have been developed to separate rare cells, e.g. circulating tumor cells. The collection and analysis of the separated rare cells pose a challenge as it may lead to loss of target cells since extremely small number of cells are usually suspended in a large volume after separation. Here, we present an integrated device that allows acoustophoretic target cell separation and

Prostate cancer patients with high WNT5A expression in their tumors have been shown to have more favorable prognosis than those with low WNT5A expression. This suggests that reconstitution of Wnt5a in low WNT5A-expressing tumors might be an attractive therapeutic approach. To explore this idea, we have in the present study used Foxy-5, a WNT5A mimicking peptide, to investigate its impact on primar

Pigment epithelium derived factor (PEDF), a ubiquitously expressed 50 kDa secreted glycoprotein, was recently discovered to regulate self-renewal of neural stem cells and have a supportive effect on human embryonic stem cell growth. Here, we analyzed expression of PEDF in the murine hematopoietic stem cell (HSC) compartments and found that PEDF is highly expressed in primary long-term HSCs. Theref

Objectives The aim was to investigate the variation in risk of breast cancer between occupational groups with a focus on white-collar and blue-collar workers and to investigate to what extent the differences were explained by risk factors related to reproduction and lifestyle. Methods Between 1991 and 1996, 14 119 women born between 1923 and 1950 and residents of Malmö, Sweden, were included in th

BACKGROUND: Analysis of circulating tumor cells (CTC) is a promising prognostic marker in castration-resistant prostate cancer (CRPC). The aim of this study was to investigate CTC detection and phenotyping as prognostic biomarkers for response to primary androgen deprivation therapy (ADT) of metastatic prostate cancer (PC). METHODS: PC patients presenting with a prostate specific antigen (PSA) >80

Deficient production of anti-viral interferons (IFNs) may be involved in causing viral-induced asthma exacerbations. Hence, drugs inducing lung IFN production would be warranted. Azithromycin may reduce asthma exacerbations but its modus operandi is unknown. Here, we investigated if azithromycin induces IFNβ expression in vitro in rhinovirus-infected bronchial epithelial cells from asthmatic donor

Chills and vomiting have traditionally been associated with severe bacterial infections and bacteremia. However, few modern studies have in a prospective way evaluated the association of these signs with bacteremia, which is the aim of this prospective, multicenter study. Patients presenting to the emergency department with at least one affected vital sign (increased respiratory rate, increased he

This paper combines theory and data collected from a shadowing study to explore the role of communication and public relations practitioners in reputation management. In seeking to explore the role communication managers have on the reputation of a CEO and the corporate reputation, this study builds on the existing research on roles research and corporate reputation. The theoretical framework conn

The aim of the study was to investigate the relationships between job satisfaction and empathic concern, perspective-taking and performance-based self-esteem. The study did also aim to examine if empathic concern, perspective-taking and performance-based self-esteem could predict job satisfaction and investigate which one was the best predictor. The survey was answered by 232 working participants

Melanoma in advanced stages is one of the most aggressive tumors and the deadliest of skin cancers. To date, the histopathological staging focuses on tumor thickness, and clinical staging is a major estimate of the clinical behavior of primary melanoma. Here we report on an observational study with in‐depth molecular profiling at the protein level including post-translational modifications (PTMs)

Outcome under-ascertainment, characterized by the incomplete identification or reporting of cases, poses a substantial challenge in epidemiologic research. While capture-recapture methods can estimate unknown case numbers, their role in estimating exposure effects in observational studies is not well established. This paper presents an ascertainment probability weighting framework that integrates

This chapter outlines the opportunities and current developments of label-free separation of circulating tumor cell (CTC) from blood cells using acoustophoresis. It describes two platforms that have been developed to enable subsequent evaluation of acoustophoresis in clinical settings. All nucleated cells in suspension flow along a microchannel wherein the cells are exposed to an acoustic field. T

The interactions between aerosols and clouds are still one of the largest sources of uncertainty in quantifying anthropogenic radiative forcing. To reduce this uncertainty, we must first determine the baseline natural aerosol loading for different environments. In the pristine and hardly accessible polar regions, the exact nature of local aerosol sources remains poorly understood. It is unclear ho

This thesis investigates the performance dynamics of serial acquirers in the Swedish market, specifically focusing on their ability to realize cost synergies over time. Through an empirical analysis of Swedish firms engaging in mergers and acquisitions (M&A) between 2010 and 2019, we aimed to determine whether serial acquirers exhibit improved synergy realization in subsequent acquisitions com

Hållbarhet har under de senaste åren fått en allt större betydelse, då den globala uppvärmningen utgör en av vår tids största utmaningar. Fastighets- och byggsektorn står totalt för 40% av den totala energikonsumtionen i Europa. EU arbetar aktivt för att minska energiförbrukningen i byggnader genom direktivet om byggnaders energiprestanda (EPBD). Det långsiktiga målet med direktivet är att unionenSustainability has become increasingly important in recent years as global warming continues to be the most serious threat to our environment. The real estate sector accounts for 40 percent of the total energy consumption in Europe. To address this issue, the European Union initiated the Energy Performance of Buildings Directive (EPBD), which aims to reduce energy consumption and achieve a fully d

Dual modulation of neuron‐specific microRNAs and the REST complex promotes functional maturation of human adult induced neurons This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/birtele_et_al-2019-febs_letters.pdf - 2026-05-14

KAP1 controls endogenous retroviruses in embryonic stem cells LETTERS KAP1 controls endogenous retroviruses in embryonic stem cells Helen M. Rowe1, Johan Jakobsson1{, Daniel Mesnard1, Jacques Rougemont1, Séverine Reynard1, Tugce Aktas2, Pierre V. Maillard1, Hillary Layard-Liesching1, Sonia Verp1, Julien Marquis1, François Spitz2, Daniel B. Constam1 & Didier Trono1 More than forty per cent of the

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/publication_in_nature.pdf - 2026-05-14

Medicinska fakulteten, Bibliotek & IKT, MHB 1 RefWorks user guide för studenter 1. Skapa ett användarkonto i RefWorks Öppna RefWorks startsida (http://www.refworks.com/) och klicka på Login. Klicka på Sign up for a New Account, fyll i uppgifterna och klicka på Create account. Det är viktigt att komma ihåg sitt login namn och sitt lösenord! När RefWorks har tagit emot alla uppgifter kan man direkt

https://www.student.med.lu.se/sites/student.med.lu.se/files/lathund-refworks.pdf - 2026-05-14