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Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by haploinsufficiency of genes encoding ribosomal proteins (RPs). Perturbed ribosome biogenesis in DBA has been shown to induce a p53-mediated ribosomal stress response. However, the mechanisms of p53 activation and its relevance for the erythroid defect remain elusive. Previous studies have indicated that activation of p53

The transcription factor STAT3 is constitutively active in several malignancies including castration-resistant prostate cancer and has been identified as a promising therapeutic target. The fungal metabolite galiellalactone, a STAT3 signaling inhibitor, inhibits the growth, both in vitro and in vivo, of prostate cancer cells expressing active STAT3 and induces apoptosis of prostate cancer stem cel

Objective: To evaluate meat intake patterns in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts. Design and setting: 24-Hour dietary recalls were assessed within the framework of a prospective cohort study in 27 centres across 10 European countries by means of standardised computer-assisted interviews. Subjects: In total, 22 924 women and 13 031 men aged 35-74 years.

https://www.saco.se/globalassets/lokala-akademikerforeningar/statlig/linkopings-universitet-liu/dokument/protokoll/protokoll20260416-signed.pdf - 2026-05-15

Microsoft Word - ENGA04 VT2022_förslag 2 .docx 1(3) Kurslitteratur för ENGA04 Engelska: grundkurs, 30 högskolepoäng, HT2022 Fastställd (senast ändrad) av styrelsen för Sektion 4, 2022-06-02 Notera att angivet tryckår anger den tidigaste upplaga som kan användas. Notera att ISBN-numret bara finns angivet för att hjälpa dig att hitta rätt bok. Om övriga uppgifter stämmer (författare, titel, år, förl

https://www.sol.lu.se/media/utbildning/dokument/kurser/ENGA04/20222/ENGA04_.pdf - 2026-05-15

SACO-rådet i Umeå kommun 2022-03-03 KALLELSE TILL SACORÅDETS ÅRSMÖTE 2022 Tid: Tisdagen den 29 mars, kl. 17.00 Plats: Teams Program: Årsmöte Anmälan: Senast 2022-03-28 till Karin Berggren, karin.berggren@umea.se. Sacorådets uppgifter är bland annat att handlägga de frågor som enskilt förbund delegerar och att vara förbundens kontaktorgan i frågor som är av gemensamt och övergripande intresse. Råde

https://www.saco.se/globalassets/lokala-akademikerforeningar/kommun-och-region/umea-kommun/dokument/kallelse-till-saco-radets-arsmote-2022.docx - 2026-05-15

Sida 1 av 12 Ver. 2023-11-07 Saco-S-rådet vid Linköpings universitet Verksamhetsberättelse för verksamhetsåret 2023 1. Styrelsen och dess arbetsfördelning Rådets styrelse har under verksamhetsåret bestått av 10 ledamöter samt 3 suppleanter utsedda vid Saco-S-rådets 2022-11-29. Därutöver utsåg årsmötet en valberedning. Till ordförande valdes: Krzysztof Marciniak, ITN, SULF (omval) Till 1:e vice ord

https://www.saco.se/globalassets/lokala-akademikerforeningar/statlig/linkopings-universitet-liu/dokument/arsmoteshandlingar/vb2023.pdf - 2026-05-15

BACKGROUND: Gleason grading is the standard diagnostic method for prostate cancer and is essential for determining prognosis and treatment. The dearth of expert pathologists, the inter- and intraobserver variability, as well as the labour intensity of Gleason grading all necessitate the development of a user-friendly tool for robust standardisation.OBJECTIVE: To develop an artificial intelligence

Acute myeloid leukemia (AML) is associated with poor survival, and there is a strong need to identify disease vulnerabilities that might reveal new treatment opportunities. Here, we found that Toll-like receptor 1 (TLR1) and TLR2 are upregulated on primary AML CD34+CD38-cells relative to corresponding normal bone marrow cells. Activating the TLR1/TLR2 complex by the agonist Pam3CSK4 inMLL-AF9-driv

Lung cancer accounts for 1.6 million deaths per year worldwide. The majority of patients are diagnosed at advanced stages of the disease and often present with metastasis. Thus, the 5-year survival rate of lung cancer remains around 15%. Early diagnosis of lung cancer allows for better control of the disease with 5-year survival rates up to around 70%. Chest radiography is the most common techniqu

The disruption of microtubule dynamics serves as a pivotal strategy for eliminating tumor cells, despite its accompanying toxicities affecting non-tumor cells. This study investigates the potential of selectively targeting γ-tubulin1 (TUBG1) as a therapeutic strategy in cancer treatment. By elucidating the TUBG1-E2F1-retinoblastoma protein (RB1) network, we introduce a novel compound, 4-(6-((3-Met

BACKGROUND: Melanoma is a highly heterogeneous disease, and a deeper molecular classification is essential for improving patient stratification and treatment approaches. Here, we describe the histopathology-driven proteogenomic landscape of 142 treatment-naïve metastatic melanoma samples to uncover molecular subtypes and clinically relevant biomarkers.METHODS: We performed an integrative proteogen

Prostate specific antigen (PSA) is a well-established tumor marker, which is frequently employed as model biomarker to develop and evaluate emerging quantitative proteomics techniques, partially due to wide access to commercialized immunoassays serving as "gold standard". We designed a multiple reaction monitoring (MRM) assay to detect PSA proteoforms in clinical samples (n=72), utilizing specific

Brevmall RHI K02 Litteraturlista Humaniora och teo log i Centrum fö r teo log i och re l ig ionsvetenskap Litteraturlista för RHI K02 Religionshistoria: Kandidatkurs, 30 hp, HT 2015 fastställd av studierektor 2015-05-11 Delkurs 1. Levd religion – traditionella och nyskapande ritualer, 7,5 hp Bell, Catherine (2009 [1997]). Ritual: Perspectives and Dimensions. Oxford University Press. ISBN: 978-0199

https://www.ctr.lu.se/media/utbildning/dokument/kurser/RHIK02/20152/RHI_K02_Litteratur.pdf - 2026-05-14

This work reports a method to select the optimal working frequency in transversal bulk resonator acoustophoretic devices by electrical impedance measurements. The impedance spectra of acoustophoretic devices are rich in spurious resonance peaks originating from different resonance modes in the system not directly related to the channel resonance, why direct measurement of the piezoelectric transdu

BACKGROUND: Owing to the large variation in treatment response among patients with high-risk prostate cancer, it would be of value to use objective tools to monitor the status of bone metastases during clinical trials. Automated Bone Scan Index (aBSI) based on artificial intelligence has been proposed as an imaging biomarker for the quantification of skeletal metastases from bone scintigraphy.OBJE

PURPOSETo assess interval cancer rate in a large, prospective digital breast tomosynthesis (DBT) screening trial in comparison with a concurrent screening population and to assess tumor characteristics of interval cancers in DBT-screening.METHOD AND MATERIALSThe prospective ****Trial, comparing digital breast tomosynthesis (DBT) with digital mammography (DM) in 14,848 women has shown a significant

Climate change and urbanisation are among the most pervasive and rapidly growing threats to biodiversity worldwide. However, their impacts are usually considered in isolation, and interactions are rarely examined. Predicting species' responses to the combined effects of climate change and urbanisation, therefore, represents a pressing challenge in global change biology. Birds are important model t