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A single genetic biomarker is unable to accurately predict the risk for venous thromboembolism (VTE) recurrence. We aimed to: (a) develop a multiple single nucleotide polymorphisms (SNPs) model to predict the risk of VTE recurrence and (b) validate a previously described genetic risk score (GRS) and compare its performance with the model developed in this study. Twenty-two SNPs, including establis
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate
Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of over
Background Nocturia is one of the most prevalent and bothersome lower urinary tract symptoms (LUTS) in men, leading to increased morbidity and mortality and a considerable economic burden on healthcare systems. Understanding its natural history, effect of pharmacotherapy, and predictors of failure of pharmacotherapy would allow optimised patient management. Objective To evaluate the prevalence an
Deposition of aerosol nanoparticles using an electrostatic precipitator is widely used in the aerosol community. Despite this, basic knowledge regarding what governs the deposition has been missing. This concerns the prediction of the size of the particle collection zone, but also, perhaps more importantly, prediction of the nanoparticle concentration distribution on the substrate, both of which a
To make glomerular filtration rate (GFR) estimating equations applicable across populations with different creatinine generation by using rescaled serum creatinine (sCr/Q) where sCr represents the individual creatinine level and Q the average creatinine value in healthy persons of the same population. GFR measurements (mGFR, plasma clearance of 51Cr-EDTA) were conducted in 964 adult Black European
Understanding microbes in nature requires consideration of their microenvironment. Here, we present a protocol for quantifying biomass and nutrient degradation of bacterial and fungal cultures (Pseudomonas putida and Coprinopsis cinerea, respectively) in microfluidics. We describe steps for mask design and fabrication, master printing, polydimethylsiloxane chip fabrication, and chip inoculation an
Production of red blood cells relies on proper mitochondrial function, both for their increased energy demands during differentiation and for proper heme and iron homeostasis. Mutations in genes regulating mitochondrial function have been reported in patients with anemia, yet their pathophysiological role often remains unclear. PGC1β is a critical coactivator of mitochondrial biogenesis, with incr
Background: Careful assessment of the reasons for discontinuation of active surveillance (AS) is required for men with prostate cancer (PCa). Objective: Using Movember's Global Action Plan Prostate Cancer Active Surveillance initiative (GAP3) database, we report on reasons for AS discontinuation. Design, setting, and participants: We compared data from 10 296 men on AS from 21 centres across 12 co
Recent insect decline prompts rapid online monitoring solutions with specificity for thousands of coexisting species.I demonstrate how microscopic and nanoscopic features of insects can aid differentiation of species and be retrieved with spectral lidar.
Under de senaste åren har antalet vårdnadstvister som avgjorts i domstol ökat markant i Sverige. Samtidigt har Sverige blivit ett mer mångkulturellt samhälle med en ökad arbetskraftsinvandring och kontinuerliga flykting- strömmar. I dagsläget har fler familjer än någonsin anknytning till utlandet vilket förstärker vissa problem inom familjerätten. Flera barn blir varje år olovligen bortförda ifrånIn recent years, the number of custody disputes settled in court has increased significantly in Sweden. This as a consequence of that Sweden has become a more multicultural society with increased labor migration and continuous refugee flows. Currently, more families than ever have links with foreign countries, which reinforces certain problems within family law. Several children are unlawfully abd
7,3 miljoner flickor under 18 år föder varje år. En av tre flickor i länder med låg- eller medelinkomst kommer att gifta sig före 18 års ålder. Detta är en kränkning mot flickor och deras mänskliga rättigheter. United Nations Population Fund, UNFPA arbetar med att stärka kvinnors och unga människors möjligheter att leva ett hälsosammare och ett mer produktivt liv. Med detta i åtanke är syftet att
Synergieffekter med ett avrinningsområdesperspektiv vid utformning av klimatstrategier Klimatförändringen ställer krav på naturmarken vi har i Sverige i form av utsläppsminskning, kolinlagring och klimatanpassning. Då avrinningen kan öka eller minska beroende på markanvändning är det viktigt med ett avrinningsområdets perspektiv vid utformningen av klimatstrategier. Det är särskilt angeläget då öClimate change places pressure on rural land in terms of carbon sequestration, biomass for substitution and adaptation of crops. Land use can both positively and negatively influence the runoff regime, therefor a catchment perspective is important when developing climate strategies. This is also important with respect to flood-risk that will increase with climate change. Here I investigate if ther
Recent public opinion research and elite deliberation has established a particular interest in galvanizing an EU army to better enforce a sense of integration, stability and strengthin the Union. This article proposes an alternative mechanism, privileging Richard Rosecrance’s concept of the ‘virtual state’ as anequally important and worthyfactor contributing to all those aspects. The fourdefining
Denna studie fokuserar på Säkerhetspolisens hotbildsframställningar av den våldsfrämjande islamistiska extremismen och studien syftar till att undersöka hur hotbildsframställningarna förändrats efter terrorattentatet på Drottninggatan i Stockholm den 7 april 2017. Studien är en abduktiv och teorikonsumerande fallstudie som använder sig av en kombination av säkerhetiseringsteorin och gestaltningste
De senaste femton åren har den radikala frihetliga vänstern i Umeå utvecklats från slutenhet och militans till öppenhet och pragmatisk inblandning i lokala konflikter. Uppsatsen intresserar sig för hur dessa förändringar korresponderar mot utvecklingsprocesser i rörelsens interna liv. Specifikt analyseras på vilka sätt rörelsens kollektiva självförståelse som politisk aktör konstruerats, hur dess
The purpose of this study was to examine five Swedish soldiers' experiences of offensive war technique while serving for 6 months in Afghanistan. In particular, focus was on their experiences of dealing with mental stress and their need for support before, during and after their mission. Semi-structured interviews were conducted with five individuals who had served in Afghanistan between the y
Sverige har en lång tradition av industriell verksamhet vilket har lett till att områden har förorenats. Jönköpings län har bland annat präglats av kvarnverksamhet där betning av utsäde bedrivits. Betning utfördes för att skydda sädeskornets ytskikt mot svampangrepp när det såddes ut på åkrarna. Betningsmedlet som användes var Panogen som är en metylkvicksilverförening. Användningen av detta betni
