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Aims/hypothesis: Rapid and adequate islet revascularisation and restoration of the islet–extracellular matrix (ECM) interaction are significant factors influencing islet survival and function of the transplanted islets in individuals with type 1 diabetes. Because the ECM encapsulating the islets is degraded during islet isolation, understanding the process of revascularisation and engraftment afte
Background and Objectives: Our objective was to study the effect of storage time on the filtration of platelet concentrates (PCs). We compared the total number of white blood cells (WBC), as well as the distribution of WBC subsets, in units filtered before and after storage. Materials and Methods: Buffy coat-derived PCs were filtered either fresh or after 5 days of storage, and total WBC were enum
Objective: Odontoblasts are thought to be involved in innate immunity but their precise role in this process is not fully understood. Here, we assess effects of lipopolysaccharide (LPS) and lipoteichoic acid (LTA), produced by Gram-negative and Gram-positive bacteria, respectively, on matrix metalloproteinase-8 (MMP-8), interleukin-6 (IL-6) and cathelin-related antimicrobial peptide (CRAMP) expres
While emotional language and imagery in protest esthetics are nothing new, emotions have been repressed in modern political discourse at large, as being seen as irrational if not dangerous. As new media platforms, such as Twitter and Facebook, are becoming central media spaces for live online broadcasting of political protests, they have become an important site of discursive struggle for research
Measurements of fiducial integrated and differential cross sections for inclusive W + , W - and Z boson production are reported. They are based on 25.0±0.5pb-1 of pp collision data at s=5.02 TeV collected with the ATLAS detector at the CERN Large Hadron Collider. Electron and muon decay channels are analysed, and the combined W + , W - and Z integrated cross sections are found to be σW+=2266±9(sta
Diabetes affects the morphology and plasticity of the hippocampus, and leads to learning and memory deficits. Caffeine has been proposed to prevent memory impairment upon multiple chronic disorders with neurological involvement. We tested whether long-term caffeine consumption prevents type 2 diabetes (T2D)-induced spatial memory impairment and hippocampal alterations, including synaptic degenerat
Oruro city in the Bolivian highlands depends solely on groundwater to supply domestic consumption and irrigation. The top porous aquifer currently exploited is not fully understood in aspects like geometry, hydrogeological properties and interaction with other aquifers in the region. Recent studies detected traces of fractures in the bedrock beneath the porous aquifer; these geological structures
With complete genealogical and cohabitation information, new genetic-epidemiological designs can be developed to clarify causes of parent-offspring transmission. We propose the Multiple Parenting Relationships (MPR) Design and apply it to drug abuse (DA) and alcohol use disorder (AUD). Using national Swedish registries, we identified four kinds of informative parents with multiple children with wh
This chapter uses the mass-conservation equations for CO2 and its isotopomers 13CO2 and CO18O that can be used to infer globally biospheric and oceanic net fluxes in the case of 18C, and gross terrestrial biospheric fluxes in the case of 18O. The quantitative use of atmospheric measurements of 13C and 18O in CO2 to better constrain those fluxes requires knowledge of various processes specific to e
With the elimination of Soviet state communism in the early 1990s, the ideational foundation of politics in the five Central Asian former Soviet republics had to undergo fundamental rebuilding. Instead of the defunct basis of Soviet-style Marxism-Leninism, the rulers of the suddenly independent Central Asian states urgently had to identify other ways and means of legitimizing their hold on power.
Background: The signal transducer and activator of transcription 3 (STAT3) pathway is observed to be constitutively activated in several malignancies including prostate cancer (PCa). In the present study, we investigated the expression of total STAT3 (tSTAT3) and two forms of activated phosphorylated STAT3 (pSTAT3
Digitalization offers unprecedented opportunities for entrepreneurial small and medium-sized enterprises (SMEs). However, many entrepreneurial SMEs lack resources and capabilities or suffer from inertia, which hampers these opportunities. This study investigates how entrepreneurial SMEs can enhance performance through digital platforms. Specifically, the study examines the effect of digital platfo
In social science discourse, the dichotomy between agency and structure tends to dominate debates pertaining to identity construction. When complex social facts are viewed through a simplistic prism of either individual activities or dominant structural impacts is likely to lead to a conclusion, - particularly when the subjects of research are members of communities at risk of vulnerability- which
Creativity is essential to knowledge production within universities and beyond. Yet, conditions for creativity receive scant scholarly attention as a feature of doctoral development, or as an element of institutional evolution within higher education. Even fewer authors have considered how creativity may be linked to doctoral students’ academic identity formation. In this paper, we analyse literat
Metal contamination of water bodies has attracted global attention owing to its environmental toxicity, abundance and persistence. Metals such as arsenic, cadmium and mercury are of greater concern since they are toxic even at low concentrations. Mercury is present at 1000 times lower concentrations than the other two metals, but still has a negative impact on the environment due to its high trans
Botulinum neurotoxins (BoNTs) are among the most potent toxins known and are also used to treat an increasing number of medical disorders. There are seven well-established serotypes (BoNT/A-G), which all act as zinc-dependent endopeptidases targeting specific members of the SNARE proteins required for synaptic vesicle exocytosis in neurons. A new toxin serotype, BoNT/X, was recently identified. It
Compound semiconductors exhibit an intrinsic polarity, as a consequence of the ionicity of their bonds. Nanowires grow mostly along the (111) direction for energetic reasons. Arsenide and phosphide nanowires grow along (111)B, implying a group V termination of the (111) bilayers. Polarity engineering provides an additional pathway to modulate the structural and optical properties of semiconductor
