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Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal disease. The only option for curative treatment is resection of the tumor followed by standard adjuvant chemotherapy. Yet, early relapse due to chemoresistance is almost inevitable. Herein, we delineated the genetic intratumor heterogeneity in resected PDAC, with the aim to identify evolutionary patterns that may be associated with ov
This article explains how the USSR's State Security Committee (KGB) inadvertently spurred the rise of a dissident movement in the Soviet Union. Under the leadership of Vladimir Semichastnyi in 1962 and 1963, the KGB launched a new offensive against “ideological subversion,” aimed primarily at Soviet intellectuals who were skeptical but not hostile in their views of Soviet Communism. These intellec
Despite urgent need for climate action, denial of climate change and resulting absence of appropriate pro-environmental behavior are widespread. Interpretive (recognition of climate change as a problem but re-interpretation of its severity) and implicatory denial of climate change (recognition of climate change as a problem but denial of psychological, political, and moral implications) can be int
The 400-km long coast of the Bight of Benin, formed by sand barriers and lagoons, is bordered to the east by the Niger River Delta and to the west by the Volta River Delta and is characterized by several coastal infrastructures, of which the most important are the deep water harbors of Lomé, Cotonou, and Lagos. In this study, an enhanced version of the CASCADE coastal evolution model was implement
This paper attempts to investigate whether there are gender and regional specific differences in risk perception in three municipalities in Sweden. It focuses on differences between gender and region with regard to risk perception, issues of trust and credibility as well as attitudes towards local industry and emergency response behaviour. This study is based on results from a larger study investi
Several groups have during past years produced molecular classification schemes for bladder cancer. Even though no consensus on how to define a subtype exists, one approach has been to base definitions on how tumours cluster according to their mRNA expression profiles. In many cases, obtained profiles, and thus class defining features, are affected by signals from non-tumour cells within the biops
The MM500 study is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in-depth histopathology coupled to proteome characterization. The protein levels and localization were determined for a broad spectrum of diverse, surgically isolated melanoma tumors originating from multiple body locations. More than 15,500 proteoforms were identified by mass spectrometry, f
Objectives. The aim of this systematic review was to describe interventions which promote safe patient handling and movement (PHM) among workers in healthcare by reviewing the literature on their effectiveness for work and health-related outcomes. Methods. Databases were searched for studies published during 1997–2018. Measures were operationalized broadly, capturing outcomes of work and health. O
The MM500 meta-study aims to establish a knowledge basis of the tumor proteome to serve as a complement to genome and transcriptome studies. Somatic mutations and their effect on the transcriptome have been extensively characterized in melanoma. However, the effects of these genetic changes on the proteomic landscape and the impact on cellular processes in melanoma remain poorly understood. In thi
Extractive industries often promise prosperity to less economically developed regions of the world. However, projects that rely on extractive industries such as mining often pose significant environmental threats to the host regions. The tension between economic promises and environmental impacts can spark significant conflict in rural communities. This study analyzes a proposed mining project in
This report highlights investigations since 2016 on the Large Igneous Provinces (LIPs), particularly based on their mafic dyke swarms (MDSs) and continental flood basalts (CFBs), from the Indian Shield. Recent research, particularly geochemistry, geochronology and paleomagnetism, allow identification and characterization of distinct generations of LIPs in space and time in the Indian Shield. This
We present results on transverse momentum (pT) and rapidity (y) differential production cross sections, mean transverse momentum and mean transverse momentum square of inclusive J / ψ and ψ(2 S) at forward rapidity (2.5 < y< 4) as well as ψ(2 S) -to-J / ψ cross section ratios. These quantities are measured in pp collisions at center of mass energies s=5.02 and 13 TeV with the ALICE detector. Both
OBJECTIVE: The late revelation of ovarian cancer ensures it as the leading cause of death among gynecologic cancers. Cytoreductive surgery (CRS) and intravenous (i.v.) chemotherapy have been the cornerstone for a long time to treat this disease. More recently, the modality of intraperitoneal administration of chemotherapy under hyperthermic conditions (HIPEC) has been added. This review surveys th
Diffusion encoding with free gradient waveforms can provide increased microstructural specificity in heterogeneous tissues compared to conventional encoding approaches. This is achieved by considering specific aspects of encoding, such as b-tensor shape, sensitivity to bulk motion and to time-dependent diffusion (TDD). In tensor-valued encoding, different b-tensor shapes are used, such as in linea
Background: The Chronic Kidney Disease in children (CKiD) equation to estimate glomerular filtration rate eGFR = k × Ht / SCr (Ht = height in cm, SCr = serum creatinine in mg/dL), with fixed k = 0.413, has recently been optimized by introducing age/sex dependent k-values valid for young children up to young adults (the CKiD Under 25 years (CKiDU25) equation). Although the CKiD equation was designe
Towards the close of the nineteenth century and into the twentieth century, there was a proliferation of Christian missionaries in Africa. Upon settling in Africa, missionaries initiated and became the main providers of Western-styled education and health care. For this reason, the historical and enduring impact of missionaries in Africa cannot be overlooked. This thesis examines the synchronic an
