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Background: Aortic valve stenosis (AVS) and coronary artery disease (CAD) have a significant genetic contribution and commonly co-exist. To compare and contrast genetic determinants of the two diseases, we investigated associations of the LPA and 9p21 loci, i.e. the two strongest CAD risk loci, with risk of AVS. Methods: We genotyped the CAD-associated variants at the LPA (rs10455872) and 9p21 loc
This study analyzes the demographics, criminality, and network relations of forty-one deceased Swedish foreign fighters. Our results show that most of the deceased Swedish foreign fighters were on average just under 26 years old when they died. Concerning network relations, nineteen out of the forty-one foreign fighters had at least one relationship (next-of-kin or friend) with another deceased fo
The UK tariff for quality of life associated with the health states in the EQ-5D is probably not consistent with the preferences of Swedish health economists. This is worrying in view of the widespread use of the tariff values and the fact that health economists likely are better able than ordinary citizens to report their preferences for health states in a valid and reliable manner. We suggest th
The adsorption from pure protein solutions and binary mixtures of proteins with opposite net charges was studied at pH 7 by in situ ellipsometry. The investigated proteins were β-lactoglobulin, lactoferrin, and lysozyme. On hydrophilic silica surfaces, β-lactoglobulin (negatively net charged) adsorbed in small amounts while lactoferrin and lysozyme (both positively net charged) adsorbed in higher
A 62-year-old previously healthy woman presented with a centroblastic non-Hodgkin's lymphoma in the thyroid. Chromosome analysis revealed two unrelated clones, 47,XX,+5 and 46,XX,-14,+der(14)t(5;14)(q11;q32). The two clones may reflect a polyclonal origin, or they may be the descendants of the same neoplastically rearranged cell. In the latter case, the clonal aberrations are either secondary to a
The hydrologic assessment of a lake water budget can be helpful in achieving proper water management and sustainable water use. A model to analyze a lake water budget was developed and verified for Lake Ikeda, Japan. Lake evaporation was estimated by numerical analyses of lake water temperature and the lake energy budget. Inflow from the lake catchment area and leakage from the lake bottom were es
Populations intermediate between the diploid and sexual Sorbus aucuparia and the tetraploid and facultative apomictic Sorbus hybrida are scattered in coastal regions of southern Scandinavia. Our aims were to investigate whether these populations were of local and independent origins, whether they were morphologically and molecularly distinct from each other and whether they could give rise to cons
Using an experimental design, this paper tackles the question of the framing impact of metaphors by focusing on the opportunity to implement a basic income (BI) system in a given polity. We take advantage of the preliminary stage of the BI debate in Belgium to study the influence of discursive strategies on the opinion formation process of individuals, since carefully choosing the arguments employ
This paper presents a measurement of jet fragmentation functions in 0.49 nb−1 of Pb+Pb collisions and 25 pb−1 of pp collisions at √sNN=5.02 TeV collected in 2015 with the ATLAS detector at the LHC. These measurements provide insight into the jet quenching process in the quark-gluon plasma created in the aftermath of ultrarelativistic collisions between two nuclei. The modifications to the jet frag
Overall survival of patients with metastatic non-small cell lung cancer (NSCLC) has significantly improved with platinum-based salt treatments and recently with targeted therapies and immunotherapies. However, treatment failure occurs due to acquired or emerging tumor resistance. We developed a monoclonal antibody against the proform of neurotensin (LF-NTS mAb) that alters the homeostasis of tumor
Background Perfluoroalkyl substances (PFAS) are used in numerous consumer products. They are persistent, bioaccumulating, and suspected to be endocrine disrupting chemicals (EDCs). A growing body of research has reported the association between PFAS exposure and adverse health effects. Concerns have been raised with special focus in childhood development. Methods Perfluoroheptanoic acid (PFHpA), p
This article explores the dynamics of state control and specific workings of state power by ethnographically examining the ways in which Chinese grassroots labor NGOs negotiate and gauge the unclear parameters permitted by the Chinese state in South China. By closely examining the everyday activism at the margins of the Chinese state, I argue that the uncertainty about the limits of the state’s to
Tyrosine phosphorylation is an important post-translation modification of proteins that is controlled by tyrosine kinases and phosphatases. Disruption of the balance between the activity of tyrosine kinases and phosphatases may result in diseases. Receptor type protein tyrosine phosphatase epsilon (PTPRE) is closely related with receptor type protein tyrosine phosphatase alpha (PTPRA). PTPRE has b
Alzheimer's disease (AD) is pathologically characterized by the accumulation of amyloid-β (Aβ) plaques, neurofibrillary tangles and widespread neuronal loss in the brain. In recent years, blood biomarkers have emerged as a realistic prospect to highlight accumulating pathology for secondary prevention trials. Neurofilament light chain (NfL), a marker of axonal degeneration, is robustly elevated in
Although Scandinavia is arguably peripheral in the global literary system, it nevertheless holds a surprisingly prominent position in the field of translation, Swedish and Danish being among the ten most translated languages in the world (Lindqvist, 2015). What literature is selected for translation and introduction into new linguistic contexts is not a coincidence, but has to do with economic fac
Acetylcholine release in the frontal cortex of awake rats after acute or chronic lesions of the nucleus basalis magnocellularis and grafting of cholinergic-rich basal forebrain tissue was studied by in vivo microdialysis. Three to four weeks and five months after a unilateral quisqualic acid lesion of the nucleus basalis, and five months after lesion and cortical implantation of a basal forebrain
Grafts of five different types of central cholinergic neurons, from the septal-diagonal band region, the nucleus basalis magnocellularis region (NBM), the striatum, the pontomesencephalic tegmentum of the brainstem, and the spinal cord, were compared with respect to their ability to grow and to reinnervate the cholinergically denervated hippocampal formation of adult rats. The areas were dissected
Animal classification is primarily based on morphological characters, even though these may not be the first to diverge during speciation. In many cases, closely related taxa are actually difficult to distinguish based on morphological characters alone, especially when there is no substantial niche separation. As a consequence, the diversity of certain groups is likely to be underestimated. Lepido
