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Gels formed from milk by renneting or acidification under quiescent conditions may subsequently show syneresis, that is, expel liquid (whey) because the gel (curd) contracts. Under quiescent conditions, a rennet-induced milk gel may lose two-thirds of its volume, and up to 90%, or even more, if external pressure is applied. Often, syneresis is undesired, for example, during storage of products lik
BACKGROUND/OBJECTIVES: High grade gliomas (HGG) are aggressive brain tumors, most frequently glioblastoma and astrocytoma grade 4. Methylation of O6-methylguanine-DNA methyltransferase (MGMT) promoter in HGG is crucial for temozolomide efficacy. As MGMT promoter methylation (MGMTpm) assessment requires tumor tissue, magnetic resonance imaging (MRI) is of interest for non-invasive prediction. We ai
The MM500 meta-study aims to establish a knowledge basis of the tumor proteome to serve as a complement to genome and transcriptome studies. Somatic mutations and their effect on the transcriptome have been extensively characterized in melanoma. However, the effects of these genetic changes on the proteomic landscape and the impact on cellular processes in melanoma remain poorly understood. In thi
BACKGROUND: Previous research has provided evidence for cognitive dysfunction as a common symptom of systemic lupus erythematosus (SLE). In light of this, the primary goal of this study was to investigate how cognitive impairment in this patient group develops over time. In addition, the present dataset contributes to delineating the specific abilities that are impaired in SLE patients as well as
BACKGROUND: The elapsed time taken to diagnose tumors of the central nervous system in children and adolescents varies widely. The aim of the present study was to investigate such diagnostic time intervals at a national level in Sweden as they correlate with clinical features.METHODS: Data prospectively accumulated over a 4-year period in the Swedish Childhood Cancer Registry from patients aged 0-
With the increasing global demand for precise and efficient pharmaceuticals and the biopharma industry moving towards Industry 4.0, the need for advanced process integration, automation, and modeling has increased as well. In this work, a method for automatic modeling and calibration of an integrated preparative chromatographic system for pharmaceutical development and production is presented. Bas
Articles 184 and 185 of the VAT Directive provide for the general obligation to adjust an initial deduction if it is higher or lower than that to which the taxable person was entitled. Does the abandonment of an investment project always imply the obligation to adjust deductions in respect of the acquired goods and/or services that cannot be used in the taxed activity of the taxable person? What i
The human pathogen Streptococcus pyogenes causes substantial morbidity and mortality. It is unclear if antibodies developed after infections with this pathogen are opsonic and if they are strain specific or more broadly protective. Here, we quantified the opsonic-antibody response following invasive S. pyogenes infection. Four patients with S. pyogenes bacteremia between 2018 and 2020 at Skåne Uni
Abstract in Czech:Studie se zabývá kultem spojeným s osobností Felixe Edmundoviče Dzeržinského (1877–1926), revolucionáře a zakladatele politické policie v Sovětském svazu, a proměnami tohoto kultu v různých etapách dějin SSSR a postsovětského Ruska. Jako vedoucí nejvýznamnější represivní složky, známé pod zkratkou Čeka, stál Dzeržinskij jasně v pozadí zcela konkrétní institucionalizované podoby sThe study discusses the cult associated with the personality of Felix Edmundovich Dzerzhinsky (1877-1926), a revolutionary and the founder of the political police in the Soviet Union, and the changing meanings of this cult in various stages of the history of the Soviet Union and post-Soviet Russia. Thanks to Dzerzhinsky, as the head of the most significant repressive component, Soviet state terror
Ridge-furrow mulching system is widely used for improving soil hydrothermal conditions and crop productivity in semiarid and arid rainfed areas. The response of crop productivity to resource capture and utilization is crucial for agricultural field management and sustainable development. However, few have simultaneously investigated the coupling effect of plastic film mulching (PM) types and plant
Despite advancements in multiple myeloma treatment, prognostic variability persists. We investigated the impact of income and education on treatment and survival in a country with publicly funded healthcare. We analysed data from the Swedish Myeloma Registry (2008–2021) linked to national registers. Cox models assessed survival, adjusting for demographics and comorbidities. Treatment patterns were
The wax apple (Syzygium samarangense) is traditionally employed as an antibacterial and immunostimulant drug in traditional medicine. This plant is rich in different flavonoids and tannins. In this study, we isolated two compounds from S. samarangense leaves: Myricitrin and 3,5-di-O-methyl gossypetin. Then, we investigated the mechanisms of action of the two compounds against oxidative stress (ind
Aims: Among patients with myocardial infarction (MI) with preserved left ventricular ejection fraction (LVEF), the REDUCE-AMI trial did not demonstrate a benefit of beta-blocker vs. no beta-blocker treatment on all-cause mortality and recurrent myocardial infarction. The aim of this pre-specified sub-study was to investigate effects of beta-blockers on self-reported symptoms of anxiety and depress
During recent years the increasing power of computers and communications has led to the use of more advanced analysis approaches within the mechanical engineering design process, or design process for short. Predictive Design Analysis (PDA), see [1], is an approach in which the final behavior of a product is predicted by combining information from different analysis techniques. This paper presents
