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Background and aims: Normative values are lacking regarding intraepidermal nerve fiber density (IENFD) in thin sections of 5 µm. Thus, we aimed to assess IENFD in thin sections in a healthy adult population as well as to investigate whether IENFD is related to age, sex, and site of excision.Methods: Archival skin biopsies or excisions at the Department of Pathology, Lund, Sweden, from arm and leg
Textile industry wastewater (WW) has intense color, high chemical oxygen demand (COD), pH, and salinity, making it challenging for conventional treatment. Soda lakes, with high alkalinity and salinity, host diverse microbes capable of textile dye degradation. This study evaluated anaerobic/aerobic reactors using alkaliphilic microbial consortia from Lake Chitu, an Ethiopian soda lake, for treating
Soil pore space, considered the most complex biomaterial that exists, generates a complex environment, that gives rise to a wide variety of properties, such as microbial diversity and carbon storage. Soils contain, at the same time, the largest carbon reservoir on earth and an immense amount of nutrient-limited microbial biomass. The reason why this carbon is not consumed by soil microbes is attri
The aim of the present European Stroke Organisation (ESO) guideline is to provide evidence-based recommendations on the acute management of patients with basilar artery occlusion (BAO). These guidelines were prepared following the Standard Operational Procedure of the ESO and according to the GRADE methodology. Although BAO accounts for only 1–2% of all strokes, it has very poor natural outcome. W
Infectious and parasitic agents (IPAs) and their associated diseases are major environmental stressors that jeopardize bee health, both alone and in interaction with other stressors. Their impact on pollinator communities can be assessed by studying multiple sentinel bee species. Here, we analysed the field exposure of three sentinel managed bee species (Apis mellifera, Bombus terrestris and Osmia
Phosphate hydrolysis is ubiquitous in biology. However, despite intensive research on this class of reactions, the precise nature of the reaction mechanism remains controversial. Herein, we have examined the hydrolysis of three homologous phosphate diesters. The solvation free energy was simulated by means of either an implicit solvation model (COSMO), hybrid quantum mechanical/molecular mechanica
European semi-natural grasslands are hotspots for biodiversity and important for the provisioning of multiple ecosystem services, but their extent has declined considerably during the past century. Increasing demands for agricultural and forest biomass risk causing further loss of grasslands, raising concern about a goal conflict between climate mitigation and biodiversity conservation. This study
Diffusion models were initially developed for text-to-image generation and are now being utilized to generate high quality synthetic images. Preceded by generative adversarial networks (GANs), diffusion models have shown impressive results using various evaluation metrics. However, commonly used metrics such as Frechet inception distance and inception score are not suitable for determining whether
Local climate adaptation is constrained and steered along specific paths by various mechanisms, which together form a lock-in. The study focuses on Swedish local civil servants’ strategies to deal with climate adaption lock-ins and to what extent the strategies disrupt the lock-ins. Interviews were conducted with civil servants in six municipalities, complemented by inter-views at regional and nat
Background: Remote symptom monitoring (RSM) is an evidence-based strategy shown to mitigate postoperative morbidity; however, platform engagement is required to benefit from RSM. Patients who report current smoking are at high risk for postoperative complications, but it is unknown whether smoking status influences engagement with RSM, symptom severity, or unanticipated acute care visits. Methods:
Simulation of conflict situations for autonomous driving research is crucial for understanding and managing interactions between Automated Vehicles (AVs) and human drivers. This paper presents a set of exemplary conflict scenarios in CARLA that arise in shared autonomy settings, where both AVs and human drivers must navigate complex traffic environments. We explore various conflict situations, foc
PURPOSE: To contribute to an in-depth understanding of how the concepts accessibility, usability, and universal design interact and can be harmonised to create conditions for participation in the 21st century.MATERIAL AND METHODS: Ideas, empirical research, and selected literature from health science, engineering, and design constituted the material for a scientifically grounded analysis.RESULTS:
Bee-mediated pollination plays a crucial role in sustaining global food production. However, while the demand for these pollination services is increasing, many bee species are in decline. To address this discrepancy, farmers use managed bee species to improve crop pollination. One key factor affecting pollination efficiency is the affinity for the crop of interest (i.e., the extent to which a bee
AIMS: This study aimed to assess the predictive value of non-invasive pressure-volume (PV) loop variables by cardiovascular magnetic resonance (CMR) for determining development of adverse remodelling 3 months after primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI).METHODS AND RESULTS: In total, 181 STEMI patients examined with CMR during the index admi
To reverse biodiversity loss, creating resilient ecological networks has been promoted in policy and practice. However, we argue that emphasising networks within policy without clear conservation prioritisations may direct focus away from ecological processes important for population persistence. We studied the rationale for resilient ecological networks represented in a policy context, by reviewi
BACKGROUND: To clarify, in a national sample, associations between risk for seven psychiatric and substance use disorders and five key transitions in Sweden's public educational system. METHODS: Swedish-born individuals (1972-1995, N = 1 997 910) were followed through 12-31-2018, at mean age 34.9. We predicted, from these educational transitions, risk for major depression (MD), obsessive-compulsiv
The ability to encode, imagine, and remember coherent representations of the world is crucial for everyday life and depends on a brain network involving the hippocampal region. Scene construction tasks, which measure spatial coherence, have been shown to be sensitive to hippocampal integrity in amnesic patients. Hippocampal dysfunction has been implicated in posttraumatic stress disorder (PTSD), a
