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Mutations in the PINK1 and PRKN genes are the most frequent genetic cause of early-onset Parkinson disease. The pathogenic p.R275W substitution in PRKN is the most frequent substitution observed in patients, and thus far has been characterized mostly through overexpression models that suggest a possible gain of toxic misfunction. However, its effects under endogenous conditions are largely unknown

A series of orthoborate-based ionic materials of bis(glycolato)borate ([BGB]) and bis(ethylene-1,2-dioxy)borate anions ([BEDB]) coupled with tetrabutylphosphonium ([P4444]) and tetrabutylammonium ([N4444]) cations have been synthesized, and their physicochemical properties are characterized. The ionic materials based on the most popular orthoborate anion, bis(oxalato)borate anion ([BOB]), which co

The model by D. Hu and D. Cai [Phys. Rev. Lett. 111, 138701 (2013). doi:10.1103/PhysRevLett.111.138701] describes the self-organization of vascular networks for transport of fluids from source to sinks. Diameters, and thereby, conductances, of vessel segments evolve so as to minimize a cost functional E . The cost is the trade-off between the power required for pumping the fluid and the energy con

This article argues that the development of regional innovation concepts, drawing primarily on the experiences of advanced regions, has led to inadequate narratives about the experience of less-developed regions (LDRs). Drawing on the extensive experience of the authors doing research in LDRs, the article develops three main arguments: first it examines the limitations of endogenous approaches to

Microhabitat conditions determine the magnitude and speed of microbial processes but have been challenging to investigate. In this study we used microfluidic devices to determine the effect of the spatial distortion of a pore space on fungal and bacterial growth, interactions, and substrate degradation. The devices contained channels differing in bending angles and order. Sharper angles reduced fu

The use of low-cost immersive virtual reality systems is rapidly expanding. Several studies started to analyse the accuracy of virtual reality tracking systems, but they did not consider in depth the effects of external interferences in the working area. In line with that, this study aimed at exploring the static-positional accuracy and the robustness to occlusions inside the capture volume of the

We consider distributed control of double-integrator networks, where agents are subject to stochastic disturbances. We study performance of such networks in terms of coherence, defined through an H2 norm metric that represents the variance of nodal state fluctuations. Specifically, we address known performance limitations of the standard consensus protocol, which cause this variance to scale unbou

Background: Biological evolution exhibits an extraordinary capability to adapt organisms to their environments. The explanation for this often takes for granted that random genetic variation produces at least some beneficial phenotypic variation in which natural selection can act. Such genetic evolvability could itself be a product of evolution, but it is widely acknowledged that the immediate sel

The pathogenesis of severe infectious diseases is a complex interplay between the host and the pathogen. The development and progression of a disease encompasses a multitude of processes, which balance between host-damage and host-protection. Proteomic analysis provides the necessary tools to interpret the extensive protein networks of host-pathogen interactions underlying the pathogenesis of a pa

Ett viktigt mål för samhället, särskilt för utbildningssystemen, är att vi människor blirbättre på att få syn på växter och på deras betydelse i ekosystemen. Vi behöver över-vinna vad som benämns ‘växtblindhet’. I denna artikel föreslår vi att variationsteoriär en bra utgångspunkt i utbildning och utvärdering av växtidentifiering inom högreutbildning. Vi redovisar exempel från svensk universitetsu

The overall aim of this paper is to introduce a new way of analysing and understanding the framing and potential of Physical Education and Health (PEH) practice. Focusing on subject-specific literacy, which is defined as an abstract and generalising language, containing words and concepts typical for a specific subject [Nestlog, B. E. (2019). Ämnesspråk – en fråga om innehåll, röster och strukture

Three species of the family Teloschistaceae (lichenized Ascomycota) are described as new to science from Southern and Eastern Siberia and the Far East. Corticolous Caloplaca saviczii belongs to the genus Caloplaca s. str.; it has C. cerina-like apothecia and green to grey-green, crateriform soralia with a white rim. Lendemeriella aureopruinosa is a saxicolous taxon with a thin grey thallus and sma

BACKGROUND: Current evidence regarding the association of serum zonulin-related proteins (ZRP) levels with prevalent inflammatory bowel disease (IBD) is contradictory. Moreover, the association with the subsequent risk of incident IBD is still unexplored. This study aimed to investigate the association of serum ZRP levels with both prevalent and incident IBD.METHOD: The study included a total of 1