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Autoimmune type 1 diabetes is strongly associated with a number of immune abnormalities that manifest themselves before and at the time of clinical diagnosis. The clinical onset is associated with a major loss of the pancreatic islet beta cells. Insulin treatment is the only treatment option since numerous trials with agents that suppress or modulate immune function have failed to preserve beta ce
High-spin states in the proton-rich nucleus V-45 have been identified for the first time. A comprehensive gamma-ray decay scheme has been established following an experiment performed at the Vivitron accelerator at IReS Strasbourg by using the Euroball gamma-ray detector array coupled to the Neutron Wall and Euclides detector arrays. The natural (negative-) parity scheme is identified up to the f(
High-spin states of the nucleus Lu-163 have been populated through the fusion-evaporation reaction La-139(Si-29, 5n) with a beam energy of 157 MeV. In addition to the two lowest excited triaxial strongly deformed (TSD) bands, recently interpreted as one- and two-phonon wobbling excitations, a third excited TSD band has been firmly established decaying to the yrast TSD band. The assignment of this
An analysis of siderophores produced by Magnaporthe grisea revealed the presence of one intracellular storage siderophore, ferricrocin, and four coprogen derivatives secreted into the medium under iron depletion. Structural analysis showed that the compounds are coprogen, coprogen B, 2-N-methylcoprogen and 2-N-methylcoprogen B. Siderophore production under low and high iron conditions was quantifi
In the narrow offshore border zone between Germany and Denmark, 550 km of high-density 3.5-kHz subbottom seismic reflection profiles were recorded within a 70-km(2) area in order to reconstruct the seismic stratigraphy of late Pleistocene to early Holocene lacustrine and fluvial environments. Using detailed line drawings, seismic facies analyses and a hierarchy of bounding surfaces, a depositional
This paper describes a model for mobile radio channels that includes consideration of directions of arrival and is thus suitable for simulations of the performance of wireless systems that use smart antennas. The model is specified for 13 different types of environments, covering macro- micro- and picocells. In this paper, a hierarchy of modeling concepts is described, as well as implementation as
The BCR gene is implicated in the development of Ph-positive leukemia through its fusion with the nonreceptor tyrosine kinase gene ABL. The normal 160 kDa Bcr protein has several functional domains, and recently one specific role for Bcr was established in the regulation of respiratory burst activity in white blood cells. Bcr expression levels are relatively constant throughout mouse development u
The ground and the excited state properties of the fullerene-linked quarter-thiophenes dyad were studied theoretically with the quantum chemistry method. To reveal the excited state properties of them in the vertical absorption process, the energies and densities of the HOMO and LUMO, the intramolecular charge transfer (ICT), locally excited (LE) are studied with transition density matrix, charge
The interaction between hydrogen peroxide and ozone has been studied in argon matrices using infrared spectroscopy. The spectra show that hydrogen peroxide forms a weak hydrogen bond to one of the end oxygens of ozone. A comparison is made with other ozone complexes.
The glacial unloading and resulting isostatic land uplift have together with hydro-isostasy, eustatic rise of sea-level and geoidal changes, ruled the shore displacement of Fennoscandia. Within the Baltic basin, periods of damming and shifts of outlet further complicated the shore displacement during the period studied, c. 12,200-8400 BP. Information on the Baltic history was derived from shorelin
We investigate correlations between geomagnetic activity indices, theNorth Atlantic Oscillation (NAO), and stratospheric geopotentialheights. It is shown that the correlation between the geomagnetic indexAp and the NAO index is high and significant since about 1970, that itis significant during winter only, that it was not significant beforeabout 1970, and that the correlations are dominated by qu
Objectives To obtain reference data representative of normal findings at anal endosonography in pregnant and non-pregnant women. To determine intraobserver and interobserver agreement in the detection of endosonographic anal sphincter defects in asymptomatic women. Methods Twenty-five non-pregnant nulliparous women and 25 non-pregnant parous women (age range, 20-67 years) and 47 pregnant women (a
Peroxidases, oxygenases and catalases have similar high-valent metal-ion intermediates in their respective reaction cycles. In this review, haem-based examples will be discussed. The intermediates of the haem-containing enzymes have been extensively studied for many years by different spectroscopic methods like UV-Vis, EPR (electron paramagnetic resonance), resonance Raman, Mossbauer and MCD (magn
The project is a part of the research programme "Timber constructions and fire" and has been financed by funds from the Swedish Fire Research Board. The aim of the project is to illustrate the possibility of calculating the fire resistance of building panels and wall constructions. The work has been planned in consultation with the steering group "Timber construction and fire" of the Swedish Fire
This study was performed to elucidate circulatory changes in the fetal cerebral circulation during uncomplicated labor and in early neonatal life. Eighteen healthy term singleton fetuses were followed longitudinally during labor. Using the transabdominal approach, and the color Doppler technique, the middle cerebral artery was identified and Doppler flow velocity waveforms recorded between and dur
