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Environmental stress can interact with genetic predisposition to increase the risk of developing psychopathology. In this work, we tested the hypothesis that social isolation stress interacts with impaired glutathione synthesis and have cumulative effects on the neurochemical profile of the frontal cortex. A mouse model with chronic glutathione deficit induced by knockout (-/-) of the glutamate-cy
Objective: To identify possible suicide risk factors in a clinical sample and suicide risk in a general population, with primary focus on mental disorders, signs, symptoms and comorbidity. Methods: In the first two studies, subjects who had been admitted to a specialised psychiatric ward after a suicide attempt were investigated. Fifteen suicide completers were compared to matched survivors in te
Investigations of past climate dynamics rely on accurate and precise chronologies of the employed climate reconstructions. The radiocarbon dating calibration curve (IntCal13) and the Greenland ice core chronology (GICC05) represent two of the most widely used chronological frameworks in paleoclimatology of the past 1/4 g50g000 years. However, comparisons of climate records anchored on these chrono
State-ownership has often been discussed as one of the major causes of poor industrial energy efficiency performance. This paper utilizes long-run historical data on the energy and material use in one specific industrial sector – the iron and steel production – in countries with both central-planning and market-based system, with a particular focus on former Czechoslovakia paralleled with the deve
In most patients, Parkinson's disease is thought to emerge after a lifetime of exposure to, and interaction between, various genetic and environmental risk factors. One of the key genetic factors linked to this condition is α-synuclein, and the α-synuclein protein is pathologically associated with idiopathic cases. However, α-synuclein pathology is also present in presymptomatic, clinically “norma
Lignin is one of the main components of plant cell walls, which provides mechanical support for plants and also contributes to resisting against plant pathogenic fungi. In the fruit industry, the lignin content can affect the quality of fruit. The biosynthesis of lignin involves a variety of enzymes, of which caffeoyl-CoA 3-O-methyltransferase (CCoAOMT) is a class of methyltransferases that plays
Live blogging from legal trials has become one of the most accessible ways in which the public can gain direct insight into legal proceedings, particularly in countries where television cameras are denied entry into the courtroom. Whilst live blogging constitutes an important way of ensuring the transparency and openness of legal processes and documents – a principle known as open justice and a ke
Active layer probing in northern Sweden, northeast Greenland, and central Svalbard indicates active layer thickening has occurred at Circumpolar Active Layer Monitoring (CALM) sites with long‐term, continuous observations, since the sites were established at these locations in 1978, 1996, and 2000, respectively. The study areas exhibit a reverse latitudinal gradient in average active layer thickne
The sea level low stand period during the Early Mesolithic in SE Baltic (c. 9,500-6,500 BC) has resulted in vast inundated areas. Some of the sites have yielded extensive remains of lagoonal and riverine sediments, as well as areas with trees preserved in situ. Investigations at one of the sites - Haväng in eastern Scania - have resulted in archaeological findings from the entire period. The prese
During the transition from the last glacial into the Holocene interglacial, the atmospheric circulation in the North Atlantic area changed from a glacial mode, influenced by the presence of large ice sheets, into a system more similar to that of the present day. This change had implications for wind, temperature and precipitation patterns that can be traced in geological archives. Here, we focus o
During the second week of August, 1,000 Swedes were asked via telephone about their opinions on the use of security cameras in public spaces. Ninety percent of the public were positive when asked the question “What do you think about surveillance cameras in public spaces?” – 49% stat- ing that they are “very positive” and 41% “quite positive”. Furthermore, 72% of the respondents stated that there
The roles of intracellular Ca2+ stores and ryanodine (Ry) receptors for vascular Ca2+ homeostasis and viability were investigated in rat tail arterial segments kept in organ culture with Ry (10 100 M) for up to 4 days. Acute exposure to Ry or the non-deactivating ryanodine analogue C10-Oeq glycyl ryanodine (10 M) eliminated Ca2+ release responses to caffeine (20 mM) and noradrenaline (NA, 10 M), w
Background: Exposure to many contacts is the main risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, while risk of serious disease and death is chiefly determined by old age and comorbidities. Relative and population-attributable fractions (PAFs) of multiple medical and social exposures for COVID-19 outcomes have not been evaluated among older adults. Objective
Northern forest ecosystems play an important role in mitigating climate change by sequestrating carbon (C), while additionally providing and regulating other ecosystem services. A majority of the Swedish environmental quality objects (EQOs) that guide Swedish environmental policy and management are associated with the forest, and they have proven difficult to achieve. Several of them relate to the
Vaccination to prevent influenza virus infection and to lessen its severity is recommended among healthcare workers (HCWs). Health professionals have a higher risk of exposure to viruses and could transmit the influenza virus to vulnerable patients who are prone to severe disease and mortality. The aim of the current study was to evaluate the levels of influenza vaccine acceptance and uptake as we
We assessed the contribution of blood pressure (BP), inflammation, and endothelial activation to the development of structural vascular and cardiac changes in hypertension. Furthermore, the effects of antihypertensive therapy were studied. We studied 114 patients with hypertension and left ventricular hypertrophy and 38 matched hypertensive subjects without cardiac hypertrophy and 38 normotensive
OBJECTIVE: To develop a diet quality index (DQI) that assesses adherence to the Swedish nutrition recommendations (SNR) and the Swedish dietary guidelines (SDG). DESIGN: A cross-sectional study within the Malmö Diet and Cancer (MDC) cohort. A diet history method collected dietary data, a structured questionnaire lifestyle and socio-economic information, and anthropometric data were collected by di
Ability to pay is recognized in most Member States as a constitutional parameter to design fair tax systems and foundations of such principle can be found also in EU primary law. However, our investigation, based on the analysis of the ECJ's case law concerning tax benefits related to personal and family circumstances, will demonstrate that ability to pay can't be considered a general prin
In 2005 the United Nations International Law Commission released the report Fragmentation of International Law: Difficulties arising from the diversification and expansion of International Law. Although fragmentation of international law had been a topic of discussion long before 2005 the report really made the debate take off, becoming one of the most debated issues in recent years among internat
