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Economic historians tend to explain US geographical development gaps in terms of industrialisation. But by the end of the 20th century, the richest counties had become specialised in services, rather than in manufacturing. This column evaluates how the service economy triggered this evident contrast between the urban and rural US. Market size causes localisation of non-agricultural activity, with

Myeloid-derived suppressor cells (MDSCs) are cells of myeloid lineage with a potent immunosuppressive capacity. They are present in cancer patients as well as in patients with severe inflammatory conditions and infections. MDSCs exist as two main subtypes, the granulocytic (G-MDSCs) and the monocytic (Mo-MDSCs) type, as defined by their surface phenotype and functions. While the functions of MDSCs

In three experiments, participants determined the orientation of a global triangle formed by three Gabor patches of a target spatial frequency in a field of distracters. The orientation of the target patches and their proximity were varied between conditions. When all the target patches had the same orientation this facilitated the response compared to random orientations. This effect occurred onl

Despite fierce criticisms, ‘rural’ and ‘urban’ still constitute powerful narratives around which we structure our society. The ‘formal reality’, however, frequently disregards the cultural nature of these concepts, elevating them to the role of objective spaces apt to serve as acceptable guiding perspectives. While the analytical inadequacy of rural-urban ideations is well-documented, the phenomen

Remarkable flight performance is key to the survival of adult Odonata. They integrate varied three-dimensional architectures and kinematics of the wings, unsteady aerodynamics, and sensory feedback control in order to achieve agile flight. Therefore, a diverse range of approaches are necessary to understand their flight strategy comprehensively. Recently, new data have been presented in several ke

Circumplanetary discs (CPDs) form around young gas giants and are thought to be the sites of moon formation as well as an intermediate reservoir of gas that feeds the growth of the gas giant. How the physical properties of such CPDs are affected by the planetary mass and the overall opacity is relatively poorly understood. In order to clarify this, we use the global radiation hydrodynamics code FA

INTRODUCTION: We studied whether adding percent free prostate-specific antigen (%fPSA) to total PSA improves prediction of clinically significant prostate cancer (csPCa) and fatal PCa.METHODS: 6727 men within the intervention arm of the Prostate, Lung, Colorectal and Ovarian Trial had baseline %fPSA. Of this cohort, 475 had csPCa and 98 had fatal PCa. Cumulative incidence and Cox analyses were con

The exchange-correlation hole and potential of the homogeneous electron gas have been investigated within the random-phase approximation, employing the plasmon-pole approximation for the linear density response function. The angular dependence as well as the time dependence of the exchange-correlation hole are illustrated for a Wigner-Seitz radius rs=4 (atomic unit). It is found that there is a su

Theorists of the transnational cleavage, defined as a political reaction against European integration and immigration, also regularly conceptualise international trade preferences as a component of this contemporary societal divide. Yet empirical analyses of this cleavage focus on the former two topics, while trade and the transnational cleavage has not been systematically investigated. Making use

The biotechnology industry has recently been demanding second generation of nanoparticle byproducts such as viruses, plasmids, virus-like particles and drug-delivery assemblies (20-300 nm). The possibility of preparing uniform nanoparticles consisting of proteins such as gelatin followed by covalent linkage of avidin was investigated. Gelatin nanoparticles were prepared by two-step desolvation. As