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The chaperone DNAJB6 can suppress fibril formation of amyloid-β. This is dependent on functionally important conserved serine (S) and threonine (T) residues located in a C-terminal domain which is dominated by β-strands. Substitution of the conserved ST-residues with alanine residues results in loss of this function. In this thesis two DNAJB6 mimic constructs are examined to see whether or not the
Biopiracy is defined as the commercial development of naturally occurring biological materials, such as plant substances or genetic cell lines, by a technologically advanced country or organisation without fair compensation to the peoples or nations in whose territory the materials were originally discovered. The problem is growing but as of today, there is no common view on how this problem shoul
The purpose of my thesis is to understand in what ways economic and productive transnationalisation affects political and social participation in the local level. Particularly, what I wish to explore are the effects of integration into the global economy over labour movements in peripheral regions. I study the ways in which workers of salmon firms in the areas of Puerto Montt and Chiloé organise a
Euroscepticism has been portrayed as the corollary of increased integration. The rapid EU development of the last fifteen years has, somehow, caused a breakdown in public support for integration. From a relative mass quiescence associated to the traditional permissive consensus over integration, European citizens have shown growing discontentment towards the EU and its orientations. This study is
The objective of the present work is to study the relationship between the European Commission and the so-called ''civil society'' through policy networks. It is considered whether a fair consultation of specialized partners can increase the level of democratic legitimacy and efficiency in the European Union. This hypothesis is considered in the light of the assumption that risk ma
Some very significant developments in antitrust law have occurred in the last decade. Many have involved a software company that is enabling the creation of this document. Of course, I am referring to the Microsoft Corporation. Both the case, which ended in a settlement agreement in the US, and the case that is under appeal in the EU will have solemn implications for the future of technology, inno
Albania has started its way to reform the newly established democratic system, since the early 90's. The legal system was one between others to be modified in compliance with the international standards set up in the international instruments. Among the reforms, the most important one was the establishment of the human rights standards, especially concerning minority rights, which is the focus
The purpose of this thesis is to position the physical and independent bookshop in the digital era, claiming that they do have a strong place there. The rationale of viewing the bookshop as a space in which an experience can be had, intends to give independent bookshops a guide on how to remain as such. I focused on an English language bookshop in Istanbul, Turkey and conducted fieldwork for 3 mon
This paper presents an exploratory case study of the factors that explain the emergence and growth of social finance in the UK. Social finance refers to an array of activities that address societal issues using finance tools and logic. The practice of social finance manifests itself in the investment in social organisations and enterprises. Investments in social finance, ultimately aim to generate
“A dagger through the skull and nothing to the wallet“ is a common expression for the situation in the squatter societies of Rio de Janeiro. It is used equally amongst the residents of the slums or “favelas” as they are called, as well as used by the recently implemented pacifying police force that work there. In Rio de Janeiro there are 17 murders committed everyday. The majority of those murders
This is a qualitative study carried out on basis of documentary studies and interviews in Kampala, Uganda. It is the result of a fieldwork issued in the mentioned location between the 2th of April and 31st of May, 2012. The thesis seeks to evaluate what lies behind the inequalities within the urban socio-spatial landscape in an African city, which will be related to carefully chosen theoretical co
Abstract: The gender pay-gap is not a new phenomenon in Brazil. Since the increase of female participation on the labor market, the gap has remained a persistent problem that has generated a wide range of studies on the topic. The Human Capital Theory argues that individuals’ education and on-the-job experience are essential determinants on wage estimations. This assessment is not disputed in the
The existence of systems has been essential in bringing order and providing benefits and security for people throughout the course of history. However there are cases wherein people have difficulties in adopting or conforming to systems. The aim of this study is to understand how systems that intend to be open encounter the paradox of excluding people in the process. The Public Transportation Age
