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In the past decade, high throughput screening (HTS) has changed the way biochemical assays are performed, but manipulation and mechanical measurement of micro- and nanoscale systems have not benefited from this trend. Techniques using microbeads (particles approximately 0.1-10 mum) show promise for enabling high throughput mechanical measurements of microscopic systems. We demonstrate instrumentat
The tremendous development in the past ten last years of the Internet and ICT at large (whether it be in general technologies like semantic modeling, knowledge mining, RFID or mobile technologies, or domain-oriented ones like e-commerce, collaborative spaces, digital mock-ups, etc.) has opened a large spectrum of potential applica-tions of ICT in the Construction sector. The real adaptation and de
We present a new way of performing hypothesis tests on scattering data, by means of a perturbatively calculable classifier. This classifier exploits the “history tree” of how the measured data point might have evolved out of any simpler (reconstructed) points along classical paths, while explicitly keeping quantum–mechanical interference effects by copiously employing complete leading-order matrix
This article examines the potential of digital welfare policies and practices to enhance the wellbeing of children in China, and the congruencies and contradictions of such policies with sustainable welfare. Can child welfare be supported digitally in ways that are not environmentally destructive? The rapidly diffusing concepts of digital welfare and sustainable welfare are presented, emphasising
Background: Coronary artery disease (CAD) is a leading cause of death worldwide and increasing cost for society. Genome wide association studies (GWAS) have identified common variants associated with CAD. Combining single nucleotide polymorphisms (SNPs) into a genetic risk score (GRS) can estimate an individual's genetic burden. Objectives: To investigate whether GRS for CAD can predict hospitaliz
The need for energy in water provision and use is obvious, however the drivers are often complex, difficult to assess, and often inconsistently presented. Here we build a clearer definition and conceptual framework of “water-related energy”. We apply this framework to harmonise data and results across disparate studies so that regional estimates of water-related energy can be compared in a consist
Sjukhusvistelser hos ett barn kan påverka hela familjen psykosocialt och praktiskt och många familjer föredrar vård i hemmet framför vård på sjukhus. Samtidigt varierar modeller för organisation, finansiering och genomförande av sjukvård i hemmet nationellt och internationellt och det kan vara svårt att överföra kunskap mellan länder och organisationer. Kunskapen om vad som är viktigt för att ge v
Peripheral nerve injuries are difficult to treat, and the clinical outcome after surgical repair and reconstruction is still insufficient, particularly concerning recovery of sensory function. To improve the clinical treatment strategies, experimental models are used to systematically examine the mechanisms behind nerve regeneration and assess the improvement of nerve regeneration by introduction
The maintenance of cell size homeostasis has been studied for years in different cellular systems. With the focus on ‘what regulates cell size’, the question ‘why cell size needs to be maintained’ has been largely overlooked. Recent evidence indicates that animal cells exhibit nonlinear cell size dependent growth rates and mitochondrial metabolism, which are maximal in intermediate sized cells wit
Aims: Abdominal aortic aneurysm is a life-threatening condition due to the risk of aneurysm growth and rupture. There are no approved diagnostic or prognostic biomarkers for abdominal aortic aneurysm. We aimed to identify diagnostic and prognostic biomarkers for abdominal aortic aneurysm and to investigate their relationship with abdominal aortic aneurysm diameter and growth. Methods: In this case
Background: The substitution of bisphenol A (BPA) by bisphenol B (BPB), a very close structural analog, stresses the need to assess its potential endocrine properties.Objective: This analysis aimed to investigate whether BPB has endocrine disruptive properties in humans and in wildlife as defined by the World Health Organization (WHO) definition used in the regulatory field, that is, a) adverse ef
Introduction: Accurate discharge summaries counteract drug-related problems due to insufficient information transfer in care transitions, but require optimal transfer and use. Careful follow-up is often essential after hospital discharge, for example when it comes to pain management in elderly patients; a common and challenging task in primary care. Aims: To assess the transfer and use of the disc
Background and Aims: Patients undergoing surgery are prone to infections, either at the site of surgery (superficial or organ-space) or at remote sites (e.g. pneumonia or urinary tract). Surgical site infections are associated with substantial morbidity and mortality, increased length of hospital stay and represent a huge burden to the health economy across all healthcare systems. Here we discuss
The ash cloud of the Eyjafjallajokull (also referred to as: Eyjafjalla (e.g. Schumann et al., 2011), Eyjafjoll or Eyjafjoll (e.g. Ansmann et al., 2010)) volcano on Iceland caused closure of large parts of European airspace in April and May 2010. For the validation and improvement of the European volcanic ash forecast models several research flights were performed. Also the CARIBIC (Civil Aircraft
Information and communication technologies (ICT) are often presented as the cure-all for various problems: ICTs for education (ICT4E) are considered promising tools for promoting self-directed, creative learning and bridging various divides, such as those between developed and developing countries, urban and rural regions, and so on. While the lofty goals of ICT4E are continuously being highlighte
This concerns Flow Induced Vibrations (Fly) in nuclear reactors and numerical analysis of such. Special attention is paid to structural excitation by sound generated remotely and turbulent flow around the structure. One hypothesis was that these phenomena can interact, so that the structure accumulates more energy from the flow if it also excited by sound from another source. In the studies, Fluid
Objectives: To characterize the utility of nitrotyrosine (NT) as a biomarker for arthritis and joint injury. Design: Synovial fluid, plasma, and urine from patients diagnosed with osteoarthritis (OA), rheumatoid arthritis (RA), anterior cruciate ligament (ACL) injury, meniscus injury and pseudogout, and knee-healthy volunteers were analyzed for concentrations of NT, nitrate and nitrite (NOx), matr
Purpose: The purpose of this study was to investigate national indication criteria tool for cataract extraction (NIKE), a clinical tool for establishing levels of indications for cataract surgery, in relation to gender differences in waiting times for cataract extraction (CE). Methods: Data were collected by The Swedish National Cataract Register (NCR). Eye clinics report to NCR voluntarily and on
