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Background: In Alzheimer’s disease (AD), the associations between tau pathology and brain atrophy and cognitive decline are well established, but imperfect. We investigate whether cerebrospinal fluid (CSF) biomarkers of biological processes (vascular, synaptic, and axonal integrity, neuroinflammation, neurotrophic factors) explain the disconnection between tau pathology and brain atrophy (brain re

Stem cell transplantation is a cornerstone in the treatment of blood malignancies. The most common method to harvest stem cells for transplantation is by leukapheresis, requiring mobilization of CD34+ hematopoietic stem and progenitor cells (HSPCs) from the bone marrow into the blood. Identifying the genetic factors that control blood CD34+ cell levels could reveal new drug targets for HSPC mobili

Numerous economic recovery packages have been implemented to stimulate green economic growth through the deployment of low-carbon technologies. The emerging literature shows, however, that there is substantial ambiguity and discrepancy about how to measure the performance of policy instruments driving a Green Economy in general, and in our case, a Green Energy Economy (GEE) in particular. Identifi

PURPOSE: Proactive management of type 2 diabetes is important for restoring beta-cell function and improving sustained blood glucose control. Evidence on quality of diabetes care in Ethiopia is inadequate.METHOD: Facility-based cross-sectional study was conducted to assess level of quality of care provided to adult type 2 diabetes patients at three public hospitals in Gamo Gofa Zone, Southern Ethi

Background Exertional breathlessness is a limiting symptom that often coexists with anxiety and depression. We tested the hypothesis that anxiety and depression negatively impact exertional breathlessness in daily life and during standardised cardiopulmonary exercise testing (CPET). Methods Analysis of people aged ⩾40 years undergoing incremental cycle CPET. Exertional breathlessness in daily life

Group A Streptococcus (GAS) forms highly deformable aggregates with broad variations in size and morphology, complicating controlled separation and biological analysis. Reliable methods to isolate fractions of GAS clusters with defined properties are essential for studying host–pathogen interactions that depend on cluster size. Here, we present a simple deterministic lateral displacement (DLD) mic

Background: Breathlessness on exertion is a common, distressing, and limiting symptom that can be quantified on incremental cardiopulmonary exercise testing (CPET) using normative reference equations. Research Question: Is the breathlessness abnormality best uncovered and assessed at symptom limitation (peak exercise) compared with submaximal exercise intensities? Study Design and Methods: This wa

Introduction: Wearable sensors measuring bodily movements used in free-living conditions may help predict falls in older persons. Assessing their use in this context is essential to identify potential challenges related to fall risk screening. Therefore, this study aimed to assess the feasibility of conducting a prospective study comparing self-rated and wearable sensor-based measures for the asse

This thesis is based on the results concerning the epitaxial growth and characterization of silicon (Si) and germanium (Ge) nanostructures. The growth technique was the Ultra High Vacuum Chemical Vapor Deposition (UHV-CVD) that works in relatively low temperatures and low growth pressures. The UHV-CVD chamber was also used for the reduction experiments. The work presented here involves three diff

The paper's empirical analysis is based on a comparative approach combining a most different systems design for case selection with within-case analyses based on process-tracing. The selected cases are examples of high-stakes situations in which tactical-level commanders have made decisions with far-reaching political repercussions. Both positive and negative outcomes are studied. A total of four

Anesthesiology is the medical specialty dedicated to the relief of pain and care of the surgical patient before, during and after surgery. Most of the work in anesthesiology is routine patient care, but because patients are sick and surgical procedures may develop in unexpected ways, anesthesiology by its nature often involves medical crises. In recent years, two concepts have gained increasing i

De senaste åren har den svenska juridiken satts under press då gängkriminaliteten i landet blomstrar. Inom det svenska rättssystemet är det särskilt bevisvärderingen som har varit en aspekt som föranlett debatter om huruvida svenska domstolar gör fullgoda värderingar. Av särskilt intresse inom bevisvärderingen är de alternativför- klaringar som presenteras i rätten och därigenom inverkar på domsluIn recent years, Swedish jurisprudence has been subject to ominous pressure parallel to the flourishing of as gang crime. Within the Swedish legal system, the evaluation of evidence has been a particular aspect that has sparked debates on whether Swedish courts make adequate assessments in such cases. Particularly, the evaluation of al- ternative explanations presented in court is of specific inte

The purpose of this thesis is to try to establish a mechanism that will enable the Commission on the Limits of the Continental Shelf to get access to legal interpretation of the United Nations Convention on the Law of the Sea. The mandate of the Commission is to validate the outer limits line delineated by coastal States. For that, the Commission has to apply provisions of the Convention. The use

Kvidingefältet ligger i nordvästra Skåne på Söderåsens nordöstra sida och avlagringen är ett delta som bildades i en havsvik under deglaciationen av området. Syftet med undersökningen är att göra en arkitektonisk analys av Kvidingedeltats tredimensionella uppbyggnad och att ta reda på hur deltautbyggnaden gått till. Sedimentologiska studier i form av översiktskartering utfördes i åtta av täkternasThe Kvidinge deposit is situated in north-western Scania, southern Sweden. It is a delta formed in a bay during the deglaciation of the area. The purpose of the investigation is to do an architectural analysis of the threedimensional build-up of the Kvidinge deposit and to reconstruct the progradation of the delta. Sedimentary studies have been performed in eight sections and seven logs have been