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Parkinson’s Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions called Lewy bodies (LB) and degeneration of dopaminergic neurons in the substantia nigra (SN). Aggregated α-synuclein (αSYN) is known to be the main component of the LB. It has also been reported to interact with several proteins and organelles. Galectin-3 (GAL3) is known to have a

Apolipoprotein E4 (ApoE4) is the most important genetic risk factor for Alzheimer's disease (AD). Among the earliest changes in AD is endosomal enlargement in neurons, which was reported as enhanced in ApoE4 carriers. ApoE is thought to be internalized into endosomes of neurons, whereas β-amyloid (Aβ) accumulates within neuronal endosomes early in AD. However, it remains unknown whether ApoE and A

Alzheimer’s disease (AD) is the most common neurodegenerative disease. Most cases of AD are considered idiopathic and likely due to a combination of genetic, environmental, and lifestyle-related risk factors. Despite occurring decades before the typical age of an AD diagnosis, early-life stress (ELS) has been suggested to have long-lasting effects that may contribute to AD risk and pathogenesis. S

The MM500 study is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in-depth histopathology coupled to proteome characterization. The protein levels and localization were determined for a broad spectrum of diverse, surgically isolated melanoma tumors originating from multiple body locations. More than 15,500 proteoforms were identified by mass spectrometry, f

Background: Bladder cancer is categorized as non-muscle invasive (NMIBC) or muscle invasive (MIBC). NIMBC makes up around 70% of the cases and although it is less aggressive, the recurrence rate is 50-70%, thus requiring extensive monitoring. Additionally, there is a risk of progression into MIBC with a 5-year survival of only 50% even when treated with radical cystectomy. Immune checkpoint inhibi

Clinical pathological diagnosis and prognosis for cancer is often confounded by spatial tissue heterogeneity. This study investigates the utility of entropy as a robust quantitative metric of spatial disorder within Fourier Transform Infrared (FTIR) chemical images of breast cancer tissue. The use of entropy is grounded in its capacity to encapsulate the complexities of pixel-wise spectral intensi

Anthropogenic changes to the environment expose wildlife to many pollutants. Among these, tropospheric ozone is of global concern and a highly potent pro-oxidant. In addition, human activities include several other implications for wildlife, e.g., changed food availability and changed distribution of pathogens in cities. These co-occurring habitat changes may interact, thereby modulating the physi

In Sweden there are many laws that apply to government archives. Amongst them are the Public Access and Secrecy Act (offentlighets- och sekretesslagen) which regulates which records are bound by secrecy and which are rendered public. The Public Access and Secrecy Act frequently makes implicit references to a protection of integrity, particularly in its treaties on extradition. To investigate what

Krillens barnkammare hotas av smältande havsis i Antarktis I den västra delen av den antarktiska halvön smälter havsisen. Den delen av södra oceanen är känd för sin stora rikedom och mängd av antarktisk krill, Euphausia superba. Krillen är beroende av havsisen för föda och beskydd. Den globala uppvärmningen försämrar krillens lekområden. Man ser nu en nedgång i krillbeståndets storlek och krillenAntarctic krill, Euphausia superba, a polar ocean specialist, thrives in the Antarctic severe physical conditions. The krill life cycle consists of strategies that have enabled and supported the species’ dominance of the Antarctic Ocean. Sea Ice extent and duration creates condition that are crucial for survival of the Furcilia larvae. The species has flexibility to food resources and is omnivorou

The hydrographical characteristics of the North Aegean Sea (NAS) have been studied using in-situ data and thermal NOAA AVHRR data. Lately, efforts to simulate the circulation patterns in the NAS have also been performed. Thus, it has been found that the discharge of water of Black Sea origin (BSW) affects extensive areas of the NAS surface waters. Another meso-scale phenomenon is the extensive upw

This study delves into the landscape of health applications within online markets. These applications, offering health-related functionalities, have become integral to the lives of European citizens. The transformation of healthcare delivery, accelerated by the pace of modern life and accentuated by the COVID-19 pandemic, has elevated health applications from conveniences to essential tools capabl

EU:s konkurrensrätt och dess amerikanska motsvarighet har ursprung som på många sätt skiljer sig från varandra. Men systemen har många likheter, och dessa verkar öka i takt med att världen blir alltmer globaliserad. Somliga ser till och med den moderniseringsprocess som genomfördes 2004 som ett uttryck för att EU accepterat delar av det amerikanska sättet att se på och tillämpa konkurrensrätten. As globalization is emerging, competition law has grown from being mainly a national matter to a global concern. Starting from different traditions, EU competition law has moved towards U.S. competition law in some ways, yet not in others. Some consider the modernization process of EU competition law, initiated in 2004, an acceptance of U.S. antitrust thinking by embracing a more economic approa

Uppsatsen syftar till att utreda hur rättstillämpningen på S:t Barthélemy fungerade i förhållande till rättstillämpningen i Sverige. Genom en rättshistorisk metod och ett komparativt perspektiv undersöks skillnaderna och likheterna mellan de två rättssystemen. Frågan besvaras genom att närmare undersöka följande tre områden: domstolens sammansättning, lagstiftningen och rättskipningen. DomstolensThe thesis aims to investigate how the adjudication in St. Barthélemy functioned in relation to the adjudication in Sweden. The differences and similarities between the two legal systems are examined through a legal historical method and a comparative perspective. The question is answered by examining the following three areas: the composition of the court, the legislation, and the administration

Stratagems adopted by democratic leaders to try to insinuate, or anchor, a preferred course of action into the larger collective will have a variety of repercussions. Beyond the apparent success of the venture itself, the long-term integrity of the democratic fabric may be at stake if simmering rancour and discontent is left unheeded. These questions would seem particularly pertinent when studyi

Choosing Your Major! As a BIDS student you have an opportunity to specialize within your degree in one of the following four disciplines: • Economic History • Human Geography • Political Science • Sociology You will make your choice during year 1 in the spring application period which occurs between mid March and mid April. Since courses may vary from one year to another, we will schedule a meetin

https://www.keg.lu.se/sites/keg.lu.se/files/choosing_your_major.pdf - 2026-05-07

1 Generella kompetenser De kunskaper och färdigheter som genereras via teoretisk utbildning vid skolor och universitet kan klassificeras på olika sätt. En skiljelinje kan dras mellan å ena sidan rena ämneskunskaper och å den andra vad som ibland kallas för ”generella kompetenser”. Den första av dessa är nog den mest uppenbara. Att man förkovrar sig i sociologi, statsvetenskap, psykologi, geografi

https://www.sam.lu.se/internt/sites/sam.lu.se.internt/files/generella-kompetenser-samfak-2016.pdf - 2026-05-07

Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development ARTICLE Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development Katarína Tiklová1, Åsa K. Björklund 2, Laura Lahti1, Alessandro Fiorenzano3, Sara Nolbrant3, Linda Gillberg1, Nikolaos Volakakis1, Chika Yokota4, Markus M. Hilscher4, Thoma

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/tiklova.pdf - 2026-05-07

Kursguide - Course Syllabus • • • • • • • Fastställande Kursplanen är fastställd av Naturvetenskapliga fakultetens utbildningsnämnd 2013- 01-09 att gälla från och med 2013-01-09, vårterminen 2013. Allmänna uppgifter Kursen är en obligatorisk kurs på grundnivå för det naturvetenskapliga kandidatprogrammet, inriktning meteorologi, vid Lunds universitet. Kursen ges även som fristående kurs. Kursen ge

https://www.nateko.lu.se/sv/sites/nateko.lu.se.sv/files/ngea16_kursplan.pdf - 2026-05-07

1 Feedback report from SWEAH External Advisory Board February 2018 Søren S.E. Bengtsen, Dorly Deeg, Lars Geschwind Introduction This is the first feedback report from the SWEAH (National Graduate School on Ageing and Health) External Advisory Board. The aim is to provide SWEAH Board and Management with reflections and recommendations for ongoing and future work. The report is based on interviews d

https://www.sweah.lu.se/sites/sweah.lu.se/files/report_1_sweah_eab_feb_2018.pdf - 2026-05-07