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INTRODUCTION:Physical activity (PA) leads to improved survival in women following the diagnosis of breast cancer, but it is less clear whether PA has equally positive effects regardless of age at diagnosis. The purpose of our study was to evaluate the association between post-diagnosis PA and survival in women aged below or over 55 years at diagnosis.METHODS:From a prospective population-based coh
OBJECTIVES: Prostate specific antigen (PSA) is a widely used and clinically valuable marker for prostate disease. In order to enable the development of new PSA assays and progress the understanding of the biology of PSA we have analyzed PSA in seminal plasma. Design and methods PSA in seminal plasma from men attending a fertility clinic and healthy controls was analyzed using SDS-PAGE, Western blo
The European Food Safety Authority (EFSA) är en EU myndighet med uppdrag att göra riskbedömningar för att stödja arbete med att upprätthålla livsmedelssäkerhet i EU. I denna studie undersöks hur EFSA kommunicerar osäkerhet i slutsatser från några av deras vetenskapliga bedömningar och om de följer den rekommenderade guiden som antogs av EFSA 2019 för kommunikation av osäkerhet. I studien har 15 stThe European Food Safety Authority (EFSA) is an EU agency, providing scientific advice and standards surrounding risk assessment in order to maintain food safety in Europe. The aim of this study was to investigate how EFSA communicates uncertainty in conditions of their assessment and if the recommended guidelines by EFSA 2019 is fulfilled. 15 Randomly picked scientific articles produced during th
Malignant melanoma has the highest increase of incidence of malignancies in the western world. In early stages, front line therapy is surgical excision of the primary tumor. Metastatic disease has very limited possibilities for cure. Recently, several protein kinase inhibitors and immune modifiers have shown promising clinical results but drug resistance in metastasized melanoma remains a major pr
BACKGROUND: Changes in glycosylation of serum proteins are common, and various glycoforms are being explored as biomarkers in cancer and inflammation. We recently showed that glycoforms detected by endogenous galectins not only provide potential biomarkers, but also have different functions when they encounter galectins in tissue cells. Now we have explored the use of a combination of two galectin
Wilms' tumor gene 1 (WT1) is a transcription factor involved in developmental processes. In adult hematopoiesis, only a small portion of early progenitor cells express WT1, whereas most leukemias show persistently high levels, suggesting an oncogenic role. We have previously characterized oncogenic BCR/ABL1 tyrosine kinase signaling pathways for increased WT1 expression. In this study, we show tha
Suppressor of cytokine signaling 2 (SOCS2) is known as a feedback inhibitor of cytokine signaling and is highly expressed in primary bone marrow (BM) cells from patients with chronic myeloid leukemia (CML). However, it has not been established whether SOCS2 is involved in CML, caused by the BCR/ABL1 fusion gene, or important for normal hematopoietic stem cell (HSC) function. In this study, we demo
Globally, malignant melanoma shows a steady increase in the incidence among cancer diseases. Malignant melanoma represents a cancer type where currently no biomarker or diagnostics is available to identify disease stage, progression of disease or personalized medicine treatment. The aim of this study was to assess the tissue expression of alpha-synuclein, a protein implicated in several disease pr
The growing interest in sustainable development indicators (SDI) has resulted in the development and application of various SDI frameworks in the past two decades. Identification and selection of “right” indicators with such frameworks are essential, in the sense that, it is the information from these indicators that will help policy and decision makers to better understand the efficiency, effecti
Den 1 juli 2018 trädde den nya förvaltningslagen (2017:900) i kraft. I lagen ges enskilda, genom införandet av en dröjsmålstalan, för första gången i svensk förvaltningsrätt en generell rätt att föra talan mot förvaltningsmyndigheters passivitet. Om unionsrätten inte anger annat kommer den nya dröjsmålstalan, enligt principen om medlemsstaternas processuella autonomi, att tillämpas även vid förvalOn the first of July 2018, the new Swedish Administrative Procedure Act came into force. The Act introduces a new remedy against the inaction of administrative authorities (an action for failure to act, in Swedish “dröjsmålstalan”). Through the introduction of the new remedy, individuals are given a general right to appeal against the administrative authorities' inaction for the first time in
En funktion som har fått mycket uppmärksamhet bland matematiker är den så kallade Riemanns zeta-funktion, som definieras med hjälp av en summa av oändligt antal termer, en så kallad serie: zeta(s) = 1 + 1/2^s + 1/3^s + 1/4^s + ... Här är s=a+ib en komplex variabel med en reell del a och en imaginär del, där i har egenskapen i^2=-1. Värdet på den här serien kommer givetvis bero på vilket värde pWe establish the central convergence properties of ordinary Dirichlet series, including the classical result by Bohr, providing uniform convergence of the series where it has a bounded analytic continuation. We also derive a lower bound for the supremum of Dirichlet polynomials using Kronecker's theorem, of which we see one proof. With this knowledge and some probability theory we can follow t
Tracking techniques are vital for the understanding of the biology and ecology of organisms. While such techniques have provided important information on the movement and migration of large animals, such as mammals and birds, scientific advances in understanding the individual behaviour and interactions of small (mm-scale) organisms have been hampered by constraints, such as the sizes of existing
Wnt5a is a non-canonical secreted glycoprotein of the Wnt family that plays an important role in cancer development and progression. Previous studies report that Wnt5a is upregulated in prostate cancer and suggested that Wnt5a affects migration and invasion of prostate tumor cell. This study aimed to evaluate the prognostic value of Wnt5a protein expression in prostate cancer tissue and its potent
Flann O´Briens The Third Policeman är skriven 1940 men publicerades 1967, efter författarens död. Några av de narrativa grepp som används i berättelsen undersöks. Tidsordningen i berättelsen jämförs med tidsordningen i den berättade storyn med utgångspunkt från teori i Gérard Genettes Narrative Discourse-An Essay in Method. Den totala tidens varaktighet (duration) i berättelsen jämförs med den tot
Transcription factor (TF)-based reprogramming of somatic tissues holds great promise for regenerative medicine. Previously, we demonstrated that the TFs GATA2, GFI1B, and FOS convert mouse and human fibroblasts to hemogenic endothelial-like precursors that generate hematopoietic stem progenitor (HSPC)-like cells over time. This conversion is lacking in robustness both in yield and biological funct
The cellular and molecular mechanisms underlying specification of human hematopoietic stem cells (HSCs) remain elusive. Strategies to recapitulate human HSC emergence in vitro are required to overcome limitations in studying this complex developmental process. Here, we describe a protocol to generate hematopoietic stem and progenitor-like cells from human dermal fibroblasts employing a direct cell
During development, hematopoietic stem and progenitor cells (HSPCs) arise from specialized endothelial cells by a process termed endothelial-to-hematopoietic transition (EHT). The genetic program driving human HSPC emergence remains largely unknown. We previously reported that the generation of hemogenic precursor cells from mouse fibroblasts recapitulates developmental hematopoiesis. Here, we dem
The human influence on Earth's ecosystems is omnipresent. Artificial light at night (ALAN), anthropogenic noise, and air pollution are inherent features of human activities and infrastructure and pose novel environmental challenges to urban-dwelling wildlife. So far, most of the studies investigating the impacts of exposure to urban pollutants on animals have either investigated the effects of urb
