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CONTEXT: Prior research suggests that drug abuse (DA) is strongly influenced by both genetic and familial environmental factors. No large-scale adoption study has previously attempted to verify and integrate these findings. OBJECTIVE: To determine how genetic and environmental factors contribute to the risk for DA. DESIGN: Follow-up in 9 public databases (1961-2009) of adopted children and their

To estimate the current and future (to year 2032) impact of osteoarthritis (OA) health care seeking.

Background and purpose - In 2003, an enquiry by the Swedish Knee Arthroplasty Register (SKAR) 2-7 years after total knee arthroplasty (TKA) revealed patients who were dissatisfied with the outcome of their surgery but who had not been revised. 6 years later, we examined the dissatisfied patients in one Swedish county and a matched group of very satisfied patients. Patients and methods - 118 TKAs i

This study examines whether neighbourhood deprivation increases the risk of hospitalization for childhood asthma, after accounting for individual-level maternal socio-demographic characteristics.

To assess knee cartilage quality and subjective knee function, 20 years after injury in anterior cruciate ligament (ACL) injured copers.

Previous studies have shown that patients diagnosed with some autoimmune (AI) diseases are at an increased risk of leukaemia but limited data are available on survival. We systematically analysed the risks (standardized incidence ratio, SIR) and survival (hazard ratio, HR) in nine types of leukaemia among 402 462 patients hospitalized for any of 33 AI diseases and compared to persons not hospitali

Introduction: One aim of modern pharmacologic treatment in rheumatoid arthritis (RA) is to prevent joint destruction and reduce the need for surgery. Our purpose was to investigate secular trends in the incidence of primary total hip and knee arthroplasties in a well defined sample of patients with RA. Methods: Prevalent cases with RA in 1997 and incident cases from 1997 to 2007 in a community bas

Perlecan is a proteoglycan composed of a 470-kDa core protein linked to three heparan sulfate (HS) glycosaminoglycan chains. The intact proteoglycan inhibits the smooth muscle cell (SMC) response to vascular injury. Hspg2(Delta 3/Delta 3) (M Delta 3/Delta 3) mice produce a mutant perlecan lacking the HS side chains. The objective of this study was to determine differences between these two types o

Background Individual-based cognitive-behavioural therapy (CBT) is in short supply and expensive. Aims The aim of this randomised controlled trial (RCT) was to compare mindfulness-based group therapy with treatment as usual (primarily individual-based CBT) in primary care patients with depressive, anxiety or stress and adjustment disorders. Method This 8-week RCT (ClinicalTrials.gov ID: NCT0147637

This article presents the analysis of a large survey on file-sharing that was conducted in April 2011 with over 75,000 respondents from all over the world. The study, also known as The Research Bay, due to that it was conducted in collaboration with the infamous BitTorrent site The Pirate Bay, by the Cybernorms research group. The aim of the online study of The Pirate Bay community has been to des

In this chapter, the modelling framework presented in Chap. 5 will be used to perform vulnerability analyses from three perspectives: global vulnerability, critical components, and geographical vulnerability. Two case studies of two real-world interdependent infrastructure systems are performed; one focusing on an electric distribution system coupled with a water distribution system, and one focus

Information technology is a vital driver in today’s business environment. Recent developments of IT have facilitated for the relatively easy creation of markets on the Internet, so called B2B-marketplaces. However, judging from the survival rate of B2B-marketplaces (5 to 10 per cent), it seems like B2B-marketplaces are doing something wrong. This paper scrutinises several theoretical frameworks re

In Mozambique, despite considerable investments in the promotion of drinking water supplies, the access to quality water of sufficient quantity for the majority of people is still far from optimal. Current official figures report that nearly half of the country´s population and about 45 per cent of urban residents do not have access to safe water. As a result of poor performance or absence of publ

Populärvetenskaplig sammanfattningAluminium används för en stor mängd produkter, allt från hus och i fordon till såvardagliga produkter som aluminiumburkar. Det breda användningsområdet beror på aluminiumets höga hållfasthet, lätta vikt och dess goda korrosionsmotståndighet. Korrosionsmotståndet beror på att när aluminium exponeras för luft bildas ett aluminiumoxidskikt på ytan, vilket skyddar aluAbstractIn this thesis, the electrochemical deposition process of Sn into ordered nanoporous anodic aluminium oxide (NP-AAO) have been studied. The deposition process was studied in situ using the X-ray techniques: X-ray diffraction (XRD), Grazing incidence Transmission Small-Angle X-ray Scattering (GTSAXS), X-ray Fluorescence (XRF) and X-ray Absorption Near Edge Structure (XANES) and ex situ usin

BACKGROUND: Oral contraceptives are known to reduce the incidence rate of endometrial cancer, but it is uncertain how long this effect lasts after use ceases, or whether it is modified by other factors.METHODS: Individual participant datasets were sought from principal investigators and provided centrally for 27 276 women with endometrial cancer (cases) and 115 743 without endometrial cancer (cont

Hereditary cancer that has monogenic inheritance affects every tenth patient, on average, who is diagnosed with cancer, and it has been suggested based on twin studies, that approximately 30% of all cancer patients have a genetic predisposition to developing cancer. The author posited that familial syndromes become more organ specific with increasing age at tumour presentation to the point that ve

Problem: Groin pain is common in soccer players but the prevalence has only been examined in uncontrolled studies. Methods: 479 male soccer players aged 25 years (17 - 43) (mean with range), 144 female soccer players aged 23 years (16 - 47), 74 men with no history of soccer training aged 26 years (16 - 42) and 94 women with no history of soccer training aged 23 years (range 15 - 43) answered a mai

Focal non-convulsive status epilepticus (fNCSE) is a neurological condition characterized by a prolonged seizure that may lead to the development of epilepsy. Emerging experimental evidence implicates neuronal death, microglial activation and alterations in the excitatory and inhibitory synaptic balance as key features in the pathophysiology following fNCSE. We have previously reported alterations