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Assessing Response System Capabilities of Socio-technical Systems

Our society is becoming more and more dependent upon the reliable function of a number of vital socio-technical systems. These systems are often being referred to as critical infrastructures, or lifeline systems, indicating their importance for supporting a nation’s economy and social well-being. In the present paper a method is presented for assessing the capability of those actors involved in re

Inducible nitric oxide synthase expression is increased in the alveolar compartment of asthmatic patients

Introduction: Increased exhaled nitric oxide (NO) levels in asthma are suggested to be through inducible NO synthase (iNOS). The aim of this study was to investigate the expression of iNOS in bronchoalveolar lavage (BAL) cells and tissue from central and peripheral airways and compare it with the exhaled bronchial and alveolar NO levels in patients with asthma vs a control group. Methods: Thirty-t

Frequency determination of rare populations by flow cytometry: A hematopoietic stem cell perspective.

Flow cytometry allows for identification of cellular subsets based on cell intrinsic properties, most often by the use of fluorochrome-conjugated antibodies recognizing distinct cell-surface epitopes that define the cells of interest. Advances in technical instrumentation and the availability of an ever-increasing number of fluorophores, today enables identification of multicolor defined cellular

The use of normal and heat-treated barley flour and waxy barley starch as anti-staling agents in laboratory and industrial baking processes

Normal and heat-treated barley, both as flour and waxy starch, were added at a concentration of 3% to a white wheat bread. The effect not only of selected additives, but also of laboratory- and industrial baking processes on stalling was evaluated. Laboratory baked breads with heat-treated barley flour differed from control breads with regard to water content, firmness and amylopectin retrogradati

A Socio-technical toolbox for business systems analysis and design

This paper provides an overview of a socio-technical toolbox (STT) based on a combination of methods from a number of contemporary socio-technical (ST) methodologies. The STT supports a pragmatic ST approach to organizational change practice and job redesign. It has been developed and used in practice in many different types of organizations over a period of many years. The use in practice of STT

Kartläggning och bedömning av säkerhetskultur - förslag till metod och applicering av metoden på två företag inom processindustrin

This report has resulted in a method to evaluate and map the safety culture within a company. The method consists of two templates. One template, the assessment template, which works as a reference point and one presentation template where simply the facts and status of the company will be presented and evaluated compared to the assessment template. Safety culture relates to attitudes, behaviour,

HAZOP and SEQHAZ® methods as input data producers to Safety Integrity Level evaluations

Today hazard studies are a self evident part of a project plan while creating a new process or making changes in an existing one in the chemical industry. Therefore it is important to make the hazard studies as efficient as possible. The objective for this thesis was to optimise the hazard study processes based on the main methods presently used at Neste Oil Oyj, Neste Jacobs Oy and Borealis Polym

Benchmarking i detaljhandelsbranschen- en fallstudie av fyra företag

Vårt syfte är att beskriva och analysera hur benchmarkinganvänds i svenska detaljhandelskedjor med inriktning mot mode. Syftet är även att behandla fallföretagens erfarenheter av benchmarkingarbetet och ta reda på om det finns potential hos styrverktyget som inte utnyttjas. Vi har utfört en kvalitativ fallstudie, med en deduktiv ansats av fyra detaljhandelskedjor. Vår teoretiska teferensram består

Relationship Between Serum Response Factor and Androgen Receptor in Prostate Cancer

BACKGROUND. Serum response factor (SRF) is an important transcription factor in castrate-resistant prostate cancer (CRPC). Since CRPC is associated with androgen receptor (AR) hypersensitivity, we investigated the relationship between SRF and AR. MATERIALS AND METHODS. Transcriptional activity was assessed by luciferase assay. Cell proliferation was measured by MTT and flow cytometry. Protein expr

Psychometric properties of the Tampa Scale of Kinesiophobia (TSK-11) among older people with chronic pain.

Abstract Objectives: The study aimed to test the construct validity, factor structure and reliability of the 11-item version of the Tampa Scale for Kinesiophobia (TSK-11, Swedish version) among older people (65+) with chronic pain. Design: Methodological study. Subjects: 433 participants with chronic pain (mean age 74.8, 65-98 years) completed postal questionnaires. 264 of the participants complet

Label-Free High-Resolution Photothermal Optical Infrared Spectroscopy for Spatiotemporal Chemical Analysis in Fresh, Hydrated Living Tissues and Embryos

Label-free chemical imaging of living and functioning systems is the holy grail of biochemical research. However, existing techniques often require extensive sample preparation to remove interfering molecules such as water, rendering many molecular imaging techniques unsuitable for in situ structural studies. Here, we examined freshly extracted tissue biopsies and living small vertebrates at submi

Risk factors for frequent unplanned hospital visits in older multimorbid patients after an emergency department visit : a retrospective cohort study

BACKGROUND: Hospital readmissions are common among older multimorbid patients, and hospitalisation is associated with functional decline and reduced quality of life. Identifying patient characteristics and risk factors for repeated hospital visits following an emergency department (ED) encounter is important for guiding targeted interventions to prevent future revisits.AIM: To characterise multimo

Using proximity extension proteomics assay to identify biomarkers associated with infarct size and ejection fraction after ST-elevation myocardial infarction

Plasma concentrations of many cardiovascular and inflammatory proteins are altered after ST-elevation myocardial infarction (STEMI) and may provide prognostic information. We conducted a large-scale proteomic analysis in patients with STEMI, correlating protein levels to infarct size and left ventricular ejection fraction (LVEF) determined with cardiac magnetic resonance imaging. We analysed 131 c

Methodology for in-line rheology by ultrasound Doppler velocity profiling and pressure difference techniques

This paper describes a methodology for measuring theological flow properties in-line, in real-time, based on simultaneous measurements of velocity profiles using an ultrasound velocity profiling (UVP) technique with pressure difference (PD) technology. The methodology allows measurements that are rapid, non-destructive and non-invasive and has several advantages over methods presented previously.