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p90 ribosomal S6 kinases (RSKs) respond to various mitogen stimuli and comprise two distinct protein kinase domains. The C-terminal kinase domain (CTKD) receives signal from ERK1/2 and adopts an autoinhibitory mechanism. Here, the crystal structure of human RSK1 CTKD is reported at 2.7 Å resolution. The structure shows a standard kinase fold, with the catalytic residues in the ATP-binding cleft or
Recent scholarly work has enhanced our understanding of how new path development activities are enabled or constrained by ‘regional environments’, made up of pre-existing industrial structures, knowledge organizations, support structures and institutional configurations. This paper moves beyond overly static views on regional environments. We develop a dynamic perspective by analysing conceptually
This chapter presents a narrative analysis of the life story of a Swedish Pentecostal who decided to join the Israeli Defense Forces out of his conviction that God wanted him to protect the chosen people. His story is treated as an example of lived Christian Zionism; as one of many manifestations that contemporary Christian affection for Israel can take. The analysis focuses on the central narrati
In this paper the Poisson bracket algebra for the open massless relativistic string in the one-space-and one-time-dimensional case is considered. In order to characterize the orbit of the system the directrix function, i.e., the orbit of one of the endpoints of the string, is used. It turns out that the Poisson bracket algebra is of a very simple form in terms of the parameters of the directrix fu
The contributions of cortico-cerebellar and cortico-striatal circuits to timing and time perception have often been a point of contention. In this review we propose that the cerebellum principally functions to reduce variability, through the detection of stimulus onsets and the sub-division of longer durations, thus contributing to both sub-second and supra-second timing. This sensitivity of the c
Purpose: In Gaucher disease, diminished activity of the lysosomal enzyme, acid β-glucosidase, leads to accumulation of glucosylceramides and related substrates, primarily in the spleen, liver, and bone marrow. Eliglustat is an oral substrate reduction therapy approved in the European Union and the United States as a first-line treatment for adults with type 1 Gaucher disease who have compatible CY
A novel low-complexity detection scheme is proposed for the multiple-input multiple-output (MIMO) single-carrier frequency division-multiple access (SC-FDMA) systems, which is suitable for ASIC implementations. The proposed detection scheme makes an initial estimate of the transmitted signal based on a minimum mean square error (MMSE) frequency domain equalizer (FDE) detector and finds symbols wit
The Potchefstroom Fire Protection Association (FPA) has an important role in preventing and managing veld fires in the Tlokwe Local Municipality’s rural environment. The FPA works closely with several governmental stakeholders, but these stakeholders do not view the FPA as having high levels of organisational legitimacy. A lack of organisational legitimacy hinders the FPA in obtaining its organisa
Pressure-driven membrane processes are often used for the separation and purification of organic compounds originating from biomass. However, membrane fouling remains a challenge as these bio-based streams have a very complex composition and comprise a high fouling tendency. Conventional, the fouling is monitored based on either a decrease in flux or an increase in pressure over time. Those conven
Background: Since the publication of the European League Against Rheumatism (EULAR) recommendations for the management of large vessel vasculitis (LVV) in 2009, several relevant randomised clinical trials and cohort analyses have been published, which have the potential to change clinical care and therefore supporting the need to update the original recommendations. Methods: Using EULAR standardis
Purpose: To propose a new simplified technique to occlude multiple segmental arteries for staging and preconditioning of the spinal cord to decrease the potential for spinal cord ischemia after thoracic and thoracoabdominal aortic aneurysm repair. Technique: A thoracic stent-graft that flares out to a maximum of 51 mm is deployed in a standard fashion covering all segmental arteries where graft-wa
BACKGROUND: People with intellectual disability (ID) have high prevalence of psychiatric disorders, but even higher rates of prescription of psychotropic drugs. METHODS: Using Swedish national registers, we identified a group of older people with ID and diagnosis of mood disorders (ICD-10 codes F32-F39) and/or anxiety (ICD-10 code F4) during 2006-2012 (n = 587) and a referent group of people from
In addition to being a key criterion of the sustainable development proviso, for business, the integration of social- and ecological considerations into decision-making is of growing importance for minimising future environmentally-related risk and associated economic costs, as well as gaining a share in growing markets favouring products and companies focusing upon social responsibility and ecolo
In an era of lifelong learning, empowerment of the learner becomes fundamental. Therefore ex-ploitation of the full potential of learning objects depends upon creation of an appropriate infra-structure to promote symmetrical control of inquiry. The learner needs to be empowered because learning is a discovery process and thus must be under his or her own control. In early stages of education it
Popular Abstract in Swedish Patienten med underbensamputation på grund av kärlsjukdom Långt före Kristi födelse var amputation av benet en känd operation. Anledningen till amputationen kunde vara kärlsjukdom, olycksfall, tumör eller medfödda missbildningar. I västvärlden idag utförs 90 % av amputationerna på grund av kärlsjukdom. Dessa patienter är äldre och sjukare än övriga benamputerade och meThe patient with unilateral trans-tribal amputation for vascular disease. Functional assessments, prognostic factors and cost of prostheses. The aims of the study were to focus on the functional ability of the dysvascular patient with unilateral trans-tibial amputation and the early rehabilitation period, defined here as the period between the amputation and the prosthetic fitting. Results revea
