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Gaussian models are frequently used for road elevations. However, these models are often only valid for short sections of the road. Here we present a comprehensive approach to describe various aspects of road surface/elevation by using extensions of Gaussian models arising from random gamma distributed variances. These random variances result in the Laplace distribution and thus we refer to the so
Magneto-responsive soft films constitute a fascinating class of smart materials and devices capable of performing various tasks, such as micromanipulation or transport, noninvasive surgery, and sensing. These components are fabricated by incorporating magnetic materials into flexible substrates. In this context, arranging magnetic particles into elongated chains exhibiting shape anisotropy has sho
Objectives: Restenosis after vessel angioplasty due to dedifferentiation of the vascular smooth muscle cells (VSMCs) limits the success of surgical treatment of vascular occlusions. Type 2 diabetes (T2DM) has a major impact on restenosis, with patients exhibiting more aggressive forms of vascular disease and poorer outcomes after surgery. Kv1.3 channels are critical players in VSMC proliferation.
Amyloid fibrils are highly insoluble in neutral aqueous media of regular ionic strengths making solubilization a difficult task that normally calls for extremely harsh treatment. This is among the reasons for the routine employment of synthetic proteins in amyloid research, where the amylogenic components are needed. Here we describe a process for solubilizing amyloid in pure water that we adopted
Many ecclesiologists assume that pluralisation is a problem for churches. By drawing on Dietrich Bonhoeffer’s reception of Ernst Troeltsch, however, the author argues that pluralisation is instead a promise. Portraits which paint Bonhoeffer as ‘alternative’ to Troeltsch (and Troeltsch as ‘alternative’ to Bonhoeffer) have been proposed persistently. But in the ecclesiological explorations which Bon
This article examines the emergence of idealism in evolutionary cognitive science by analyzing the conscious realism of the cognitive theorist Donald D. Hoffman and the mathematician Chetan Prakash. Perception is for them not about veridical experience, but rather a mechanism for survival. It helps us survive but does not give us access to reality as such. By relating Hoffman and Prakash's conscio
The access economy is rising in importance in the marketplace. In this conceptual article, we chronicle access practices in market and nonmarket economies. In nonmarket economic systems, access is gained via social exchange and primarily takes the form of sharing. That is, sharing is non-market-mediated access. In the contemporary market economy, economic exchange practices, such as renting, domin
