Sökresultat

Single-strand RNA-binding proteins (RBPs) are involved in many aspects of RNA metabolism and in the regulation of gene transcription. The RBP RBM3 was recently suggested to be a proto-oncogene in colorectal cancer; however, such a role has not been corroborated by previous studies in the colon or other tumor types, and the prognostic implications of tumor-specific RBM3 expression remain unclear. M

In this paper, we analyze the potentials of a four-phase 14-GHz CMOS voltage-controlled oscillator, tailored to a sub-harmonic receiver, for signal processing at Ka-band. When mild phase accuracies between in-phase and quadrature down-converted signals are required, the four-phase oscillator displays roughly the same phase noise figure-of-merit as quadrature oscillator counterparts. However, the o

Solar variability has been hypothesized to be a major driver of North Atlantic millennial-scale climate variations through the Holocene along with orbitally induced insolation change. However, another important climate driver, volcanic forcing has generally been underestimated prior to the past 2,500 years partly owing to the lack of proper proxy temperature records. Here, we reconstruct seasonall

INTRODUCTION: Secondary functional hypothalamic amenorrhea (SFHA) is common among female athletes, especially in weight-sensitive sports. The aim of this study was to investigate the link between SFHA and neuromuscular performance in elite endurance athletes. METHODS: Sixteen eumenorrheic (EUM) and 14 SFHA athletes from national teams and competitive clubs participated. Methods included gynecologi

In Part I of this two-part paper, a formulation was developed to treat fragmentation in ice-ice collisions. In the present Part II, the formulation is implemented in two microphysically advanced cloud models simulating a convective line observed over the U.S. high plains. One model is 2D with a spectral bin microphysics scheme. The other has a hybrid bin-two-moment bulk microphysics scheme in 3D.

Evaporation of sulfuric acid from particles can be important in the atmospheres of Earth and Venus. However, the equilibrium constant for the dissociation of H2SO4 to bisulfate ions, which is the one of the fundamental parameters controlling the evaporation of sulfur particles, is not well constrained. In this study we explore the volatility of sulfate particles at very low relative humidity. We m

Radiocarbon dating is the most commonly used chronological tool in archaeological and environmental sciences dealing with the past 50,000 years, making the radiocarbon calibration curve one of the most important records in paleosciences. For the past 12,560 years, the radiocarbon calibration curve is constrained by high quality tree-ring data. Prior to this, however, its uncertainties increase rap

This study investigates how variations in Arctic sea ice and sea surface conditions influence δ18O of present-day Arctic precipitation. This is done using the model isoCAM3, an isotope-equipped version of the National Center for Atmospheric Research Community Atmosphere Model version 3. Four sensitivity experiments and one control simulation are performed with prescribed sea surface temperature (S

This paper demonstrates how second-order time-delayed models adequate for PID controller synthesis can be identified from significantly shorter relay experiments, than used in previous publications to obtain first-order time-delayed models. Apart from having good noise robustness properties, the proposed method explicitly addresses non-stationary initial states of the dynamics to be identified, an

We establish a connection between trend filtering and system identification which results in a family of new identification methods for linear, time-varying (LTV) dynamical models based on convex optimization. We demonstrate how the design of the cost function promotes a model with either a continuous change in dynamics over time, or causes discontinuous changes in model coefficients occurring at

Despite widely acknowledged problems of aggression, presumptions on its constructive and destructive possibilities, aggression still remains scarcely explored phenomenon. The aim of this paper is to propose closer look at the subjective motivation of aggression in women. The study consisted of two stages and embraced 24 participants. As the analysis of semi-structured interviews and projective mat

Astrocytic glutamate (Glt) uptake keeps brain interstitial Glt levels low. Within the astrocytes Glt is converted to glutamine (Gln), which is released and reconverted to Glt in neurons. The Glt-Gln cycle is energy demanding and impaired energy metabolism has been suggested to cause low interstitial Gln/Glt ratios. Using microdialysis (MD) measurements from visually noninjured cortex in 33 neuroin

The Faroe Islands hold a key position in the North Atlantic region for tephra studies due to their relative proximity to Iceland. Several tephras have been described over the last 50 years in peat and lake sediment sequences, including the type sites for the Saksunarvatn and Mjáuvøtn tephras. Here we present a comprehensive overview of Holocene tephras found on the Faroe Island. In total 23 tephra

The Amazon Basin is a unique region to study atmospheric aerosols, given their relevance for the regional hydrological cycle and the large uncertainty of their sources. Multi-year datasets are crucial when contrasting periods of natural conditions and periods influenced by anthropogenic emissions. In the wet season, biogenic sources and processes prevail, and the Amazonian atmospheric composition

Analyzing seasonally resolved δ18O ice core data can aid the interpretation of the climate information in ice cores, also providing insights into factors governing the δ18O signal that cannot be deciphered by investigating the annual δ18O data only. However, the seasonal isotope signal has not yet been investigated in northern Greenland, e.g., at the NEEM (North Greenland Eemian Ice Drilling) ice

The effect of external forcings on atmospheric circulation is debated. Due to the short observational period, the analysis of the role of external forcings is hampered, making it difficult to assess the sensitivity of atmospheric circulation to external forcings, as well as persistence of the effects. In observations, the average response to tropical volcanic eruptions is a positive North Atlantic

This paper investigates the robustness of control systems when a controller is run in a Fog environment. Control systems in the Fog are introduced and a discussion regarding relevant faults is presented. A preliminary investigation of the robustness properties of a MinSeg case study is presented and commented. The discussion is then used to outline future lines of research.