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Objective - ADP plays an important role in platelet aggregation by activating P2Y(12) receptors. We assessed the hypothesis that P2Y(12) receptors are expressed in vascular smooth muscle cells (VSMC). Methods and Results - P2Y(12) receptor mRNA was found to have a high expression among the P2 receptors in human VSMC, significantly higher than the other 2 ADP receptors (P2Y(1) and P2Y(13), real-tim

Autoimmunitet och njursjukdomar

I världen lider flera 100 miljoner människor av autoimmuna sjukdomar och de är ett folkhälsoproblem i paritet med cancer och hjärt/kärlsjukdomar. Vi har fokuserat vår forskning kring en grupp ovanliga men allvarliga autoimmuna sjukdomar, ANCA associerade vaskuliter. Sjukdomarna orsakar en akut inflammation i de små blodkärlen, vilket leder till en snabbt förlöpande glomerulonefrit och livshotande Autoimmune diseases affect several 100 million people world wide and is a tremendous public health problem comparable with heart disease and cancer. We have focused our research to a group of severe autoimmune diseases, called ANCA (anti-neutrophil cytoplasmic antibody) associated systemic vasculitis. The diseases present with acute inflammation in the small vessels and cause rapidly progressive r

Celiaki och diabetes

The field of research is to uncover the genetic and environmental etiology of autoimmune (type 1) diabetes, celiac disease as well as narcolepsy. The genetics of the disease is dissected also in the spontaneously diabetic BB rat. Specific autoantibody markers are used to predict the clinical onset of diabetes or celiac disease. Longitudinal studies of children at increased risk allow studies of t

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This article focuses on how Sweden's largest tenant-owners' organization, HSB, deals with energy efficiency. The aim is to examine HSB's energy goals, how they are determined and how they should be implemented at four levels: the national association, the regional office, the local housing co-operatives and the tenant-owners. Representatives of all four levels were interviewed. Achieving energy go