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Objective To develop evidence-based recommendations on the use of imaging of the joints in the clinical management of rheumatoid arthritis (RA). Methods The task force comprised an expert group of rheumatologists, radiologists, methodologists and experienced rheumatology practitioners from 13 countries. Thirteen key questions on the role of imaging in RA were generated using a process of discussio
This paper presents an FPGA implementation of an algorithm, previously published, for the the reconstruction of cosmic rays' trajectories and the determination of the time of arrival and velocity of the particles. The accuracy and precision issues of the algorithm have been analyzed to propose a suitable implementation. Thus, a 32-bit fixed-point format has been used for the representation of the
Recent contributions to ecological economics and related social sciences indicate that issues such as climate change, resource depletion and environmental degradation cannot be effectively addressed under conditions of continued economic growth. This paper aims at empirically identifying structural potentials and policy challenges for prosperity at scaleswhere economic development remainswithin ec
Background: Songbirds hold great promise for biomedical, environmental and evolutionary research. A complete draft sequence of the zebra finch genome is imminent, yet a need remains for application of genomic resources within a research community traditionally focused on ethology and neurobiological methods. In response, we developed a core set of genomic tools and a novel collaborative strategy t
The limiting factor for lung transplantation is the lack of donor organs. The usage of lungs from donation after cardiac death (DCD) would dramatically increase donor availability. In the present paper we wanted to investigate lungs exposed to 1 h of warm ischemia without heparin followed by flush-perfusion and cold storage compared to lungs harvested from heart beating donors (HBD) using standard
Leukotriene A(4) hydrolase (LTA4H) is a key enzyme in the inflammatory process of mammals. It is an epoxide hydrolase and an aminopeptidase of the M1 family of the MA clan of Zn-metallopeptidases. We have solved the crystal structure of LTA4H in complex with N-[3(R)-[(hydroxyamino)carbonyl]-2-benzyl-1-oxopropyl]-L-alanine, a potent inhibitor of several Zn-metalloenzymes, both endopeptidases and am
A method based on hollow fiber liquid phase microextraction (HF-LPME) for analysis of pinic acid and pinonic acid was developed and for the first time successfully applied to ambient aerosol samples. In this method, the aerosol samples were dissolved in 0.05M H(2)SO(4) and the solution was extracted using three-phase HF-LPME where donor phase was 0.1M (NH(4))(2)CO(3). Different parameters like typ
Patients with perihilar cholangiocarcinoma and gallbladder cancer extending into the hilum often present with jaundice and a small future liver remnant (FLR). If resectable, preoperative biliary drainage and portal vein embolization (PVE) are indicated. Classically, these measures have been performed sequentially, separated by 4-6 weeks.
Background: In adults, impaired myocardial repolarization and increased risk of arrhythmia are known consequences of open heart surgery. Little is known, however, about post-operative consequences of cardiopulmonary bypass surgery in children. The aim of this study was to assess ventricular repolarization and coronary perfusion after bypass surgery for atrial septal defect (ASD) repair in children
This Letter presents a search at the LHC for s-channel single top-quark production in proton-proton collisions at a centre-of-mass energy of 8 TeV. The analyzed data set was recorded by the ATLAS detector and corresponds to an integrated luminosity of 20.3 fb(-1). Selected events contain one charged lepton, large missing transverse momentum and exactly two b-tagged jets. A multivariate event class
Problem discussion: Uptime availability is an essential parameter in profitable production within the oil and gas industry. Several installations have a problem achieving their uptime availability target as platforms stand still for shorter or longer periods of time. A reduced uptime availability can cause significant losses for the platform. The power supply is a constant subject within the indus
The health and environmental impacts of food consumption are increasingly recognized as sustainability issues in developed countries. Therefore, promotion of sustainable diets is becoming more popular among governments and International NGOs. However, the question persists of how best to do this. While the determinants of behavioural change have been studied extensively, the motivations behind beh
The purpose of this study is an understanding of operator work in a production line and its connection and translation into simulation. A mapping of operator work in the production line was performed, after which tasks and were analysed for their relevance for simulation. A model draft was developed in the software FlexSim. The mapping and the derived model provides insight into operator work in t
The issue of an increasing number of people globally that are adopting unsustainable lifestyles is important because we are destroying the earth’s resources at an accelerating rate. In particular, the pattern of major increasing environmental impact caused by modern food production has the potential to become an important sector for climate change mitigation, but despite the myriad of guides avai
Syftet med denna undersökning var att undersöka om ekonomivärden prioriteras framför demokrativärden i kommuners beslutsunderlag. Frågeställningen var; Dominerar ekonomivärdena framför demokrativärdena i de beslutsunderlag vars kommuner vi har valt att undersöka? Beslutsunderlag för nyetablering och avveckling av särskilda boenden granskades i sex svenska kommuner under mandatperioden 2010-2014. E
Våldtäktslagstiftningen ändrades den första juli 2013 genom införandet av begreppet ”särskilt utsatt situation” som ersatte det dåvarande begreppet ”hjälplöst tillstånd”. Skälet till denna ändring var att begreppet hjälplöst tillstånd hade tillämpats för snävt då det bland annat ställdes för höga krav i praxis för att en person skulle anses befinna sig i ett hjälplöst tillstånd. Dessa brister syntThe Swedish rape law was changed on July 1st, 2013, through the introduction of the concept ”particularly vulnerable situation” that replaced the former wording ”helpless state”. The reason behind this change was that the courts had applied the concept helpless state narrowly. The demands were too high for someone to be in a helpless state. These deficiencies occurred particularly when applying th
Det finns olika möjligheter för barn att få komma till tals och det är domstolens skyldighet att se till att barnets åsikter kommer fram i målet. Barn kan för det första få komma till tals i en vårdnadsutredning eller innan snabbupplysningar sker av socialnämnden. För det andra kan barnet också komma till tals inför rätten. I praktiken har det funnits brister i hur tillämpningen av rätten att koFamily law disputes concerning the custody, residence and contact of children have increased in recent years. Judgments made by the court in the resolution of disputes have significant short and long term consequences for the children involved. The child is not a party to the proceedings. Instead the child has a right to be heard and a right to have his or her best interests taken as a primary con
