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The Particle Finite Element Method (PFEM) is attractive for the simulation of large deformation problems, e.g. in free-surface fluid flows, fluid–structure interaction and in solid mechanics for geotechnical engineering and production processes. During cutting, forming or melting of metal, quasi-incompressible material behaviour is often considered. To circumvent the associated volumetric locking
Post-marketing reports of suspected adverse drug reactions are important for establishing the safety profile of a medicinal product. However, a high influx of reports poses a challenge for regulatory authorities as a delay in identification of previously unknown adverse drug reactions can potentially be harmful to patients. In this study, we use natural language processing (NLP) to predict whether
Patients and families facing serious illness often want and need their clinicians to help guide medical decision making by offering a recommendation. Yet clinicians worry that recommendations are not compatible with shared decision making and feel reluctant to offer them. We describe an expert approach to formulating a recommendation using a shared decision-making framework. We offer three steps t
Accurate regulation of microfilament dynamics is central to cell growth, motility and response to environmental stimuli. Stabilizing and depolymerizing proteins control the steady-state levels of filamentous (F-) actin. Capping protein (CP) binds to free barbed ends, thereby arresting microfilament growth and restraining elongation to remaining free barbed ends. In all CPs characterized to date, a
Accurate estimation of reference evapotranspiration (ETo) is essential for effective water resources management, irrigation system design, and various hydrological and agricultural applications. This study employed extreme gradient boosting (XGBoost) model, signal decomposition techniques, and XGBoost coupled with Nelder–Mead (NM) method to enhance ETo prediction across two meteorological stations
BACKGROUND: Anastomotic leakage after rectal cancer surgery is linked to reduced survival and higher recurrence rates. While an aggravated inflammatory response may worsen outcomes, few studies have explored the combined effects of leakage and inflammation.METHODS: This is a retrospective multicenter cohort study including patients operated with anterior resection for rectal cancer in Sweden durin
The regional small intestinal permeability to the vasopressin analogue desmopressin (dDAVP) was further characterized in proximal jejunal and distal (ileocecal) segments of the rat. Administration of the peptide to closed small intestinal loops confirmed the existence of regional absorption differences also in vivo in rats. Thus, the extent of absorption was about 4 times as high from the ileoceca
Background and Objective: This narrative review addresses idiopathic acute pancreatitis (IAP) and its epidemiology, diagnosis, clinical course and treatment during the last decade. As there is no previously validated protocol for finding the aetiology of acute pancreatitis (AP), the primary aim of this study is to find, describe and unify evidence about the diagnostic work-up of AP to diagnose the
Background and Objectives Structural brain MRI and blood-based phosphorylated tau (p-tau) measures are among the least invasive and least expensive Alzheimer's disease (AD) biomarkers to date. The extent to which these biomarkersmay outperformone another in predicting future Alzheimer dementia diagnosis is poorly understood, however. This study investigated 2 specific AD biomarkers, i.e., a cortic
Infectious diseases are one of the leading causes of mortality in the world. Severe infections can manifest in many ways, creating a heterogeneous clinical and molecular disease landscape that renders these diseases difficult to research, diagnose, and treat. To investigate the molecular mechanisms of infectious disease, we apply mass spectrometry-based proteomics to analyze blood plasma samples f
The Vimmerby Moraine is the only significant ice-marginal moraine on the eastern side of southern Sweden, but no detailed studies exist on its formation during the final deglaciation of the Fennoscandian Ice Sheet. Through ground-penetrating radar surveys and detailed sediment logging, we provide evidence for an active, oscillating ice margin during the formation of the Vimmerby Moraine, suggestin
The invasive golden apple snail Pomacea canaliculata is one of the devastating threats to aquatic ecosystems and wetland agriculture worldwide. Macrolides from microbes display various advantages over other compounds in controlling snails. However, emergence of antibiotic-resistant phenotypes against certain macrolides in the field appeals for exploring more effectively molluscicidal macrolides. H
In this paper, we propose a new methodology for optimal memory mapping of data and instructions to Scratch-Pad Memories (SPM). In the mapping process, we optimize, as the main priority, the number of memory accesses to minimize power consumption. Minimization of external memory accesses lowers switching activity and therefore power consumption. The optimization is done by finding Pareto-points, us
