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To identify from a patient's perspective, difficulties and differences in the comprehension of five global presenteeism measures in patients with inflammatory arthritis and OA across seven countries.

-Despite recent discoveries of new genetic risk factors, the majority of risk for coronary artery disease (CAD) remains elusive. As the most proximal sensor of DNA variation, RNA abundance can help identify subpopulations of genetic variants active in and across tissues mediating CAD risk through gene expression.

In a genome-wide scan, we show that 30 variants in 25 genomic regions are associated with risk of TN breast cancer. Women carrying many of the risk variants may have 4-fold increased risk relative to women with few variants.Triple-negative (TN) breast cancer is an aggressive subtype of breast cancer associated with a unique set of epidemiologic and genetic risk factors. We conducted a two-stage ge

Noise, vibration and harshness (NVH) is a big consideration in the automotive industry. In order to create an as pleasant driving experience as possible for the driver, NVH should be minimized. One of the sources of NVH comes from the transmission due to the synchronization process. When shifting between gears, the speeds of the target gear and the output shaft it is supported by, have to be synch

Bygg- och fastighetsbranschen utgör i dagsläget en betydande andel av Sveriges naturresursutvinning samt klimatpåverkan, där påverkan från traditionella stommar av betong och stål länge har dominerat. Klimatintensiva processer såsom cement- och stålproduktion är bidragande faktorer till att branschen är i behov av en hållbar och cirkulär omställning. Återbruk och cirkulärt byggande erbjuder hållbaToday, the construction and real estate industry accounts for a sizable portion of the market´s material consumption and climate impact, with traditional structural materials such as concrete and steel long dominated. Processes such as cement and steel production contribute to the industry´s need for a sustainable transition and circular transition. Reuse and circular construction offer sustainabl

Uppsatsen undersöker frågan samebyars avtalsrätt. Frågan är intressant eftersom samebyar i viss mån kan jämföras med ekonomiska föreningar. Juridiska personer har vanligtvis avtalsfrihet, men samebyars möjligheter är begränsade. Enligt ren-näringslagen får samebyarna inte ingå avtal om upplåtelse, och det är endast rege-ringen som får förordna om ett upphörande av renskötselrätten. År 2020 medde-lThis essay examines the contractual capacity of Sámi villages. While these villages are, in legal terms, comparable to economic association and thus possess legal personality, their ability to enter into agreements is subject to legal constraints. Unlike typical legal entities Sámi villages are not free to contract as they wish. Under the Reindeer Husbandry Act, Sámi villages are prohibited from g

The antibody microarrays have become widespread, but their use for quantitative analyses in clinical samples has not yet been established. We investigated an immunoassay based on nanoporous silicon antibody microarrays for quantification of total prostate-specific-antigen (PSA) in 80 clinical plasma samples, and provide quantitative data from a duplex microarray assay that simultaneously quantifie

Objective: In the present study, we investigated the role of the gut–liver crosstalk in the pathogenesis of steatotic liver disease (SLD) induced by the compounding and deleterious effects of alcohol and metabolic risk factors, and explored the potential translational aspects of microbiome-based interventions. Design: The effects of combined exposure to alcohol and a high-fat, high-cholesterol die

This study critically explores the launch of the mission for 100 climate neutral cities in Europe. Key elements of the mission are introduced and analysed along with some of its challenges and ambiguities.

Introduction: Familial risk of lung cancer (LC) is at the level of many common cancers (ca 2.0) but as cigarette smoking is the main cause of LC, it has remained undefined to what extent smoking contributes to the familial risk. We take advantage of the natural experiment of divorce. In Sweden, it has been customary that children stay with their mother after divorce. We thus hypothesize that only

BACKGROUND: Children with autism spectrum disorder (ASD) are at increased risk of epilepsy (EP), but distinguishing epileptic seizures from ASD-associated behavior remains a clinical challenge. Although previous studies have reported changes in peripheral immune markers in adults with EP, it remains unclear whether similar immune signatures are present in pediatric patients with both ASD and EP, a

AIMS: Vascular atherosclerotic calcification is a pathological process marked by the abnormal deposition of calcium minerals in the intima. Asporin (ASPN) is a small leucine-rich proteoglycan which interacts with collagen and calcium. Due to its role in matrix mineralization, we hypothesized that ASPN might act as a regulator of vascular calcification, thereby promoting atherosclerotic plaque stab

During the 2022 Winter Paralympic Games in Beijing, the Para snow-sport events will be held at high altitudes and in possibly cold conditions while also requiring adjustment to several time zones. Furthermore, the ongoing COVID-19 pandemic may lead to suboptimal preparations. Another concern is the high rate of injuries that have been reported in the Para alpine and snowboard events. In addition t

Introduction Artifi cial intelligence (AI) algorithms for interpreting mammograms have the potential to improve the effectiveness of population breast cancer screening programmes if they can detect cancers, including interval cancers, without contributing substantially to overdiagnosis. Studies suggesting that AI has comparable or greater accuracy than radiologists commonly employ € enriched' datas