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Analytical sociology is a methodological strategy aimed at refining theoretically informed empirical social research. Given the central assumption that the role of sociology is to explain macro level phenomena, analytical sociology makes pragmatic use of abstract models of social action and interaction, such as the DBO-model. The realization that it is not a philosophy or a psychology, nor a unive

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α-Synuclein is a presynaptic protein associated to Parkinson's disease, which is unstructured when free in the cytoplasm and adopts α helical conformation when bound to vesicles. After decades of intense studies, α-Synuclein physiology is still difficult to clear up due to its interaction with multiple partners and its involvement in a pletora of neuronal functions. Here, we looked at the remarkab

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Denna studie har strävat efter att undersöka hur högerorienterade digitala alternativa nyhetssidor i USA porträtterar politik i sin nyhetsrapportering. För att undersöka detta har studien utfört en kvalitativ gestaltningsanalys av hur två av USA:s största högerorienterade alternativa nyhetssidor, Breitbart News och The Daily Caller, rapporterade om riksrättsprocessen mot Donald Trump inom tidsrame

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The study contributes to a deeper understanding of the customer experience journey regarding high involvement products and touchpoints that influence the customer experience in a physical store. This study serves as an extension to previous academic research as they focused on convenience goods with a different target group (Lemon & Verhoef, 2016). Furthermore, the research conducted has sever

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Maternal effects have become an important field of study in evolutionary ecology and there is an ongoing debate regarding their adaptive significance. Some maternal effects can act to increase offspring fitness and are called 'adaptive maternal effects'. However, other maternal effects decrease offspring fitness and there is confusion regarding whether certain maternal effects are indeed adaptive

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We show, through a combination of density function theory-based molecular dynamics simulations (DFT-MD) and experimental X-ray absorption fine structure spectroscopy (XAFS) studies, that the iodate ion (IO 3 -) contains a local region that is strongly hydrated as a cation. The local region adjoining the I atom is sufficiently electropositive that thr

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Observationally, the galactic chemical evolution of sulphur shows a complex pattern. Some studies find no correlation between [S/Fe] and [Fe/H] at halo metallcities, which is typical for alpha -elements, others find [S/Fe] increasing towards lower metallicities, and still others find a combination of the two. Each scenario has different implications for the Galactic chemical evolution of sulphur.

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While the major drivers of melanoma initiation, including activation of NRAS/BRAF and loss of PTEN or CDKN2A, have been identified, the role of key transcription factors that impose altered transcriptional states in response to deregulated signaling is not well understood. The POU domain transcription factor BRN2 is a key regulator of melanoma invasion, yet its role in melanoma initiation remains

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A new and freely available model-based PID design tool for Matlab is introduced. It can be used to solve Maximal Integral Gain Optimization (MIGO) and (load) Integral Absolute Error (IAE) problems. Robustness is ensured through H-inf constraints on the closed-loop transfer functions. A Youla parameter (Q design) method for comparison with the optimal linear time-invariant (LTI) controller for the

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Apelin, a recently discovered peptide with wide tissue distribution, regulates feeding behavior, improves glucose utilization, and inhibits insulin secretion. We examined whether apelin is expressed in human islets, as well as in normal and type 2 diabetic (T2D) animal islets. Further, we studied islet apelin regulation and the effect of apelin on insulin secretion. Apelin expression and regulatio

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In everyday conversations, we frequently give an example. Yet this is seldom accompanied by any reflection on what is going on when we do so. This report tries to contribute such a reflection. It shows how examples may be marked and used in a particular discourse: oral discourse on others. The empirical material is a transcribed focus group interview with a group of Swedish students, engaged in di

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Term synonymous variation is widely used, but frequently in a wrong or misleading meaning and context. Twenty three point eight % of possible nucleotide substitution types in the universal genetic code are for synonymous amino acid changes, but when these variants have a phenotype and functional effect, they are very seldom synonymous. Such variants may manifest changes at DNA, RNA and/or protein

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The identification of a permanent establishment is the principle used by the Member States of the European Union to determine whether a company is subject to the tax jurisdiction of a State. In the digital context, the notion of permanent establishment is often questioned by States, as companies can provide services remotely without having any physical presence in the territory of a State. This th