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Specialized epitope tags are widely used for detecting, manipulating or purifying proteins, but often their versatility is limited. Here, we introduce the ALFA-tag, a rationally designed epitope tag that serves a remarkably broad spectrum of applications in life sciences while outperforming established tags like the HA-, FLAG®- or myc-tag. The ALFA-tag forms a small and stable α-helix that is func

Pancreatic Ductal Adenocarcinoma (PDAC) is a very aggressive disease, lacking effective therapeutic approaches and leaving PDAC patients with a poor prognosis. The life expectancy of PDAC patients has not experienced a significant change in the last few decades with a five-year survival rate of only 8%. To address this unmet need, novel pharmacological targets must be identified for clinical inter

Adult human joint cartilage lesions do not spontaneously heal. Patients with isolated articular cartilage lesions make up perhaps some 1% of the total number of patients examined by arthroscopy. Symptoms such pain and locking, and the suggestion that the untreated lesions may progress to osteoarthritis form the basis for current attempts to repair articular cartilage by cell transplantation and ot

Purpose: This paper aims to present empirical results exemplifying challenges related to information security faced by small and medium enterprises (SMEs). It uses guidelines based on work system theory (WST) to frame the results, thereby illustrating why the mere existence of corporate security policies or general security training often is insufficient for establishing and maintaining informatio

Following a brief introduction on the history of Corporate Social Responsibility (CSR) and the concept of the Circular Economy (CE), the impact of the dairy industry on the environment is introduced. This study then focuses on the gaps in research and the problem of implementing CE practices in the dairy industry. After a review of the literature on the Circular Economy and the Business Model, thi

Given the recent changes in how central banks use the tools they have at hand to control inflation and money supply this study aims to evaluate the effect that interest rate policy has had on IPO underpricing. More specifically, the effect that negative interest rate policies and quantitative easing has had on the size of the underpricing premium. To test these effects, we collected IPO data from

In LSS staff´s work with autism they relate daily to the international diagnostic manual (DSM) where the American Psychiatrich Association has categorized and globalized the diagnostic criteria. The work has been debated and criticized by social anthropologists as an expression of society's need to categorize, to medicalise suffering and to globalize western expression of suffering. Every day

Human milk fat is a concentrated source of energy and provides essential and long chain polyunsaturated fatty acids. According to previous experiments, human milk fat is partially lost during continuous enteral nutrition. However, these experiments were done over relatively short infusion times, and a complete profile of the lost fatty acids was never measured. Whether this loss happens considerin

Keeping global warming below 1.5°C is technically possible but is it politically feasible? Understanding political feasibility requires answering three questions: (a) “Feasibility of what?,” (b) “Feasibility when and where?,” and (c) “Feasibility for whom?.” In relation to the 1.5°C target, these questions translate into (a) identifying specific actions comprising the 1.5°C pathways; (b) assessing

Scholars in urban political ecology, urban geography, and planning have suggested that urban greening interventions can create elite enclaves of environmental privilege and green gentrification, and exclude lower-income and minority residents from their benefits. Yet, much remains to be understood in regard to the magnitude, scope, and manifestations of green gentrification and the forms of contes