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Background: Successful cardiac resynchronization therapy (CRT) requires appropriate left ventricular (LV) lead placement on a suitable segment of the free LV wall. Current guidelines suggest targeted lead placement, but the individual anatomy of the cardiac veins is often a limiting factor. Purpose: To map cardiac veins with multidetector computed tomography (MDCT) and plot the veins in cardiac se

BACKGROUND: Arsenic methylation efficiency, a susceptibility factor for arsenic toxicity, is in adults partly explained by variation in arsenite methyltransferase (AS3MT) gene. Little is known about the role of AS3MT for children's arsenic methylation.OBJECTIVES: Evaluating associations between AS3MT polymorphisms and children's arsenic methylation efficiency.METHODS: Bangladeshi children's arseni

Background: The proportion of adults with liver disease due to severe alpha-1-antitrypsin deficiency (AATD), with PiZZ phenotype, is not clear. The markers of the AATD liver disease, how it progresses, and measures for its prevention have not been established. The aim of this study was to analyze the risk of liver disease in individuals with severe AAT deficiency (PiZZ). Methods: Longitudinal clin

Background: It has previously been reported that venous cannulation-induced pain (VCP) can be used to predict acute postoperative pain after laparoscopic cholecystectomy. Patients rating VCP at ≥2.0 VAS units had 3.4 times higher risk for moderate or severe pain. The purpose of this study was to evaluate if VCP scores of ≥2.0 VAS units are associated with higher risk for acute postoperative pain a

A Credit Default Swap spread is a reliable measure of credit risk as it is the compensation demanded by a party to bear this risk. Officially, credit risk is denoted as credit ratings announced by credit rating agencies. Since rating announcements contain information regarding credit risk, the market should incorporate this new information into the CDS spread. The aim of this study is to investiga

Relapsed or recurrent breast cancer is the chief cause of breast cancer related deaths and it is estimated that one-third of breast cancer patients would likely suffer a relapse. Due to high mortality and incidence, recurrent breast cancer requires better means of prediction, prevention and treatment. The AFFIRM platform uses recombinant antibody technology and selected reaction monitoring (SRM) m

3D-modell av höftbenet kan hjälpa till att förutspå artros Det är viktigt att förebygga sjukdomar innan de bryter ut. Vanliga 2D-röntgenbilder är inte alltid tillräckligt noggranna men med 3D-modeller kan tidiga tecken på artros lättare identifieras. Vi strävar för att få fram 3D-bilder av höften från vanliga röntgenbilder.Osteoarthritis and osteoporosis are two medical conditions involving the hip which affect the life quality of many people worldwide. These two diseases are diagnosed with 2D imaging by analysis of radiological measures, bone mineral density and joint space. Computed Tomography (CT) can provide 3D images of the hip, but has higher cost and imposes a higher radiation dose to the patient. Another op

Nowadays, many evacuation models exist in the market, and new models are continuously released with new features. How to assess the usability and reliability of model results becomes an issue for both developers and users. Therefore, verification and validation (V&V) protocols were introduced in the assessment process of evacuation models. To conduct V&V of a model, a widely accepted test

Connecting science to political agenda-setting is essential for a sustainable transition and acceptable politics. This task is complicated by phenomena like post-truth, for which facts are a non-issue. However, post-truth is not the only issue. The practice of political spin, in which the significance of facts is reconstructed according to specific interests poses another threat to scientific cred

Fokus på plast i mark och jord: mikroplasters effekt på organismer i jord undersökt med ny teknologi inom jordekologi frågor. De enorma plastutsläppen till naturen är idag ett välkänt problem. Det är också välkänt att plast bryts ner till mindre partiklar med andra effekter, så kallade mikro- och nanoplaster. Allmänheten har visat stort intresse kring plastproblematiken i haven och mycket forskniThis study aims to investigate if micro- and nanoparticles of polystyrene affect microorganisms in soil. This was tested by using microfluidic chips, which are new for investigation of soil ecology questions, providing artificial channels reflecting soil conditions as well as being transparent for seeing real-time interactions. Eight microfluidic chips were made; four were filled with a micro- and

The construction of episodic memory is an automatic process. Event segmentation theory proposed that segmentation of the continuous perceptual stream into separate memory events occurs when changes in external boundaries lead to changes in internal perceptual and conceptual boundaries. The influence of perceptual and conceptual boundaries on episodic memory encoding has been the subject of intensi

Cytostatika är läkemedel som används för att behandla cancer genom att hämma eller stoppa celldelning. De används även som immunhämmande medel, till exempel vid organtransplantationer och autoimmuna sjukdomar. Eftersom dessa läkemedel påverkar cellers tillväxt kan de vara skadliga även i mycket små mängder om de hamnar i miljön. Cytostatika har upptäckts i ytvatten, grundvatten och dricksvatten i Introduction: Cytostatic pharmaceuticals are increasingly detected in the aquatic environment, raising concerns due to their persistence and toxicity. Background: Conventional wastewater treatment processes do not effectively remove these compounds. Advanced oxidation processes, such as ozonation, are needed to degrade cytostatic pharmaceuticals during wastewater treatment. However, these process

The first aim of this study was to on historical background survey women's alcohol habits and especially to investigate women aged 50-59 living in the Lund area. The second aim was to increase the understanding of how women's sex role has a restrictive influence on their alcohol habits. To investigate women's alcohol habits I made two quantitative studies. From secondary data I found t

Previous studies have found that launch prices reflect the therapeutic gains of pharmaceuticals (for instance: Ekelund and Persson, 2003, on Sweden and Lu and Comanor, 1998, on the US). Furthermore, Howard et al (2015) found that purely pharmaceutical costs to “Medicare” at launch for new anticancer drugs increased annually, from 1995-2013, after controlling for health benefits and inflation. This

Populärvetenskaplig sammanfattning: Utvärdering av borrhålsloggar. Syftet med detta examensarbete var att göra en utvärdering av wireline borrhålsloggar från borrhålet Kyrkheddinge-4, 3 km öster om Staffanstorp i Skåne. Den undersökta delen av borrhålet Kyrkheddinge-4 befinner sig inom den potentiella reservoarsandstenen, Lundasandstenen. Wireline borrhålsloggar är geofysiska verktyg som används This study is an evaluation of formation characteristics, as derived from wire-line well logs, of the Lund Member in the borehole Kyrkheddinge-4, 3 km east of Staffanstorp, Skåne, Sweden, through the comparison to measured core data. The purpose is to assess the feasibility of using some of the porosity and permeability equations and cross-plots derived for the investigated section and applying th