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We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai
Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami
Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway display limited survival benefits in patients and resistance often develops due to activation of alternative pathways. Thus, finding and validating new targets is highly warr
Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat
EndoS from Streptococcus pyogenes efficiently hydrolyzes the functionally important and conserved N-linked glycan of IgG in human blood. Repeated i.v. administration of EndoS in rabbits completely hydrolyzes the glycans of the whole IgG pool, despite the generation of anti-EndoS antibodies. EndoS administration had no apparent effects on the health of the animals. EndoS hydrolysis of the IgG glyca
Podcast time! Podcast time! Published 26 November 2020 Marianne Gullberg is a guest in two different podcasts this week! Podcast #1 (In Swedish) Som en del av firandet av Vetenskapssocieteten i Lunds 100-årsjubileum och Humaniora 2020 har Vetenskapssocieteten spelat in fyra utforskande samtal med kända lundaforskare kring ämnet ”Vad är en människa?”. Programledare för inspelningarna är Hannes Sapi
https://www.humlab.lu.se/article/podcast-time - 2026-06-25
Rapporten belyser resultaten från ett Plattformsfinansierat projekt som löpt från 2018 till 2019 med syfte att undersöka dels olika besökares informationsbeteende i Helsingborg, dels vilket värde besökarna tillskriver de olika informationskanalerna. Frågan är hur vi kan förstå besökarna i ett allt mer digitalt sammanhang. Vilka informationskanaler är intressanta för besökarna och vilket värde till
Background: A significant proportion of patients with asthma have persistent symptoms despite treatment with inhaled glucocorticosteroids. Objective: We hypothesized that in these patients, the alveolar parenchyma is subjected to mast cell-associated alterations. Methods: Bronchial and transbronchial biopsies from healthy controls (n = 8), patients with allergic rhinitis (n = 8), and patients with
2026 Gordon Research Conference on Image Science, April 26 - May 1, 2026:Leading experts in imaging will gather for five days of talks, discussions, and poster sessions, exploring cutting-edge advances across optical, MRI, X-ray, and other imaging modalities. The conference highlights innovations in instrumentation, computational methods, and AI, tackling challenging scenarios from biology to astr
https://www.fysik.lu.se/en/education/xanadu-graduate-research-school/news - 2026-07-09
Read more and register About the Euprera Annual Congress The European Public Relations Education and Research Association (EUPRERA) is an autonomous organisation with over 550 members across 50 countries, with a vision of advancing academic research and knowledge in public relations and strategic communication. To achieve this vision, EUPRERA organises a highly regarded Annual Congress in collabor
https://www.isk.lu.se/euprera2025 - 2026-07-09
Tumor-specific monoclonal antibodies (mAbs) offer several modes of tumor cell killing, from direct cytotoxic activity to indirect mechanisms employing the host immune system, particularly its innate branch. The latter effector functions seem to dominate among clinically approved anti-cancer mAbs and major efforts are being undertaken by both academia and the pharmaceutical industry with the aim to
A new type of continuous, supermacroporous, monolithic, cryogel affinity adsorbent was developed, allowing specific fractionation and separation of human peripheral blood lymphocytes in a chromatographic format. The affinity adsorbent was used to design a novel cell separation strategy, which was based on the interaction of protein A from Staphylococcus aureus with cells bearing IgG antibodies on
In this paper, the authors show that liquid-liquid partition chromatography in an aqueous two-phase system offers unique possibilities of comparing the overall surface properties of intact antibodies in solution before and after binding of antigen. The authors demonstrate that the surface properties of antigen-antibody complexes are dependent on the variable regions of the antibodies, the nature o
Popular Abstract in Swedish Komplementsystemet utgör en del av den medfödda immuniteten och är viktigt i försvaret mot angripande mikroorganismer. Ärftlig C2-brist (C2D) är en av de vanligaste bristerna inom komplementsystemet och förekommer i en frekvens av 1: 20 000 hos personer med västerländsk härstamning. I de aktuella undersökningarna har mer än 40 personer med C2D identifierats och observerThe complement system is a part of the innate immunity and is essential in the defence against microorganisms. Hereditary C2 deficiency (C2D) is one of the most common complement deficiency states with an estimated prevalence of 1:20,000 in persons of Western descent. In the present investigation, the identification of more than 40 C2D persons at a single centre combined with long observation peri
