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Survival after childhood cancer diagnosis has remarkably improved, but emerging evidence suggests that cancer-directed therapy may have adverse gastrointestinal late effects. We aimed to comprehensively assess the frequency of gastrointestinal and liver late effects among childhood cancer survivors and compare this frequency with the general population. Our population-based cohort study included a
Increasing trends of natural organic matter (NOM) in surface water in Nordic countries may cause future problems for drinking water producers. Emerging membrane technology, such as ultrafiltration (UF) and nanofiltration (NF), has the potential to produce safe drinking water of good quality from sources with high organic concentrations. In the present pilot study, surface water from three sources
Existing criteria recommended by ACC/ESC for identifying patients with ST-elevation myocardial infarction (STEMI) from the 12-lead ECG perform with high specificity (SP), but low sensitivity (SE). In our previous study, we found that the SE of acute ischemia detection can be markedly improved without any loss of SP by calculating, from the 12-lead ECG, ST elevation in 3 vessel-specific leads (VSLs
Rotational CARS (Coherent anti-Stokes Raman Spectroscopy) was used to measure temperature and relative oxygen concentrations in the exhaust gas of a catalytic combustor. This laser technique has the general advantages of such techniques, i.e. possibility of performing in-situ measurements with high spatial and temporal resolution, and non-intrusiveness. Profiles of temperature and oxygen concentra
Fungal cells are exposed to rapidly changing environmental conditions, in particular with regard to the osmotic potential. This requires constant remodeling of the cell wall and, therefore, the cell wall integrity (CWI) MAP-kinase pathway plays a major role in shaping the fungal cell wall to protect from adverse external stresses. To provide a comprehensive functional analysis of the Ashbya gossyp
Researchers have emphasized the child’s perspective within social science since the 1990’s which has resulted in a shift in the view of children within research towards the recognition that children are active, creative social agents in their own right. The main aim of this paper was to present methodological and ethical aspects regarding research with children on the basis of two propositions, th
This essay introduces environmental historians to a new approach inspired by the burgeoning field of Wissensgeschichte; that is, the study of societal circulation of knowledge. It is argued that this new method can help us to better map out and analyse the emergence of modern environmentalism in society at large. To demonstrate the practical implications of the argument the essay is centred on an
Background Childhood cancer has been associated with long-term risk of urinary tract diseases, but risk patterns remain to be comprehensively investigated. We analysed the lifetime risk of urinary tract diseases in survivors of childhood cancer in the Nordic countries. Methods We identified 32,519 one-year survivors of childhood cancer diagnosed since the 1940s and 1950s in the five Nordic cancer
Background: Childhood tension-type headache (TTH) is a prevalent and debilitating condition for the child and family. Low-cost nonpharmacological treatments are usually the first choice of professionals and parents. This study examined the outcomes of specific strength training for girls with TTH. Methods: Forty-nine girls aged 9–18 years with TTH were randomized to patient education programs with
This paper uses the cloud resolving Active Tracer High-resolution Atmospheric Model coupled to the interactive surface model Hybrid in order to investigate the diurnal development of a lake-breeze system at the Nam Co Lake on the Tibetan Plateau. Simulations with several background wind speeds are conducted, and the interaction of the lake breeze with topography and background wind in triggering m
What do employees need in order to be innovative? In this paper, we explored how employees with different lengths of tenure within the research and development (R&D) department of a company in the automotive industry answer this question. We found that the needs vary depending on the length of the employee's tenure. New employees view innovation as an organisational work issue and employees wi
In this study, a rapid and sensitive ultra-high performance supercritical fluid chromatography-mass spectrometry (UHPSFC-MS) method has been developed and partially validated for the separation of carotenoids within less than 6 min. Six columns of orthogonal selectivity were examined, and the best separation was obtained by using a 1-aminoanthracene (1-AA) column. The length of polyene chain as we
Crystallographic screening of the binding of small organic compounds (termed fragments) to proteins is increasingly important for medicinal chemistry-oriented drug discovery. To enable such experiments in a widespread manner, an affordable 96-compound library has been assembled for fragment screening in both academia and industry. The library is selected from already existing protein-ligand struct
Ethiopia is currently facing the worst drought in its modern history, resurrecting the world’s collective memory of the tragedy of the 1980s. But such severe meteorological conditions may not be so rare in the future: the observed and projected impacts of changing climatic conditions in Ethiopia point towards a considerable worsening of food security status for many smallholder households. In our
Background: Mantle cell lymphoma (MCL) is an aggressive disease with short median survival. Molecularly, MCL is defined by the t(11;14) translocation leading to overexpression of the CCND1 gene. However, recent data show that the neural transcription factor SOX11 is a disease defining antigen and several involved signaling pathways have been pin-pointed, among others the Wnt/β-catenin pathway that
Objective: Changes in medical education have resulted in less available time for plastic surgery, which might jeopardise the availability of plastic surgery for patients. The aims of this study were to investigate the level of knowledge within and attitudes towards plastic surgery among medical students, and find predictors for a wish to pursue a career in plastic surgery. Methods: A previously us
