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Objective: To facilitate a greater likelihood of favorable response to new disease-modifying therapies, recruitment of patients at an earlier stage of their disease into clinical trials may be an attractive strategy. Hence, there is a need to develop widely accepted classification criteria for early-stage knee osteoarthritis (OA). We have proposed a set of classification criteria for early-stage k
This study evaluates a clinically applicable lentiviral vector for treatment of Gaucher disease type 1. Hematopoietic stem cells transduced with the vector and transplanted into a mouse model successfully halted or reversed pathology. These data were used as proof-of-concept for regulatory filing enabling the commencement of an international phase 1/2 clinical trial.
A novel sliding vane rotary compressor with a rotating cylinder is proposed in this paper. The sliding vane dynamics analysis reveals that, compared with the traditional compressor, the friction loss at the sliding vane tips and between rotor and cylinder can be reduced to 0.25% and 10.23%. To numerically investigate the internal flow mechanism, a reliable three-dimensional simulation method is de
The rapid expansion of oil palm is a major driver of deforestation and other associated damage to the climate and ecosystem in tropical regions, especially Southeast Asia. It is therefore necessary to precisely detect and monitor oil palm plantations to safeguard the ecosystem services and biodiversity of tropical forests. Compared with optical data, which are vulnerable to cloud cover, the Sentin
Lytic polysaccharide monooxygenases (LPMOs) are enzymes that bind polysaccharides followed by an (oxidative) disruption of the polysaccharide surface, thereby boosting depolymerization. The binding process between the LPMO catalytic domain and polysaccharide is key to the mechanism and establishing structure-function relationships for this binding is therefore crucial. The hyperfine coupling const
Full-thickness eyelid flaps from the lower eyelid are frequently used to repair larger upper eyelid defects. Perfusion monitoring has recently been implemented in several reconstructive surgical procedures, however, perfusion monitoring of a rotational eyelid flap has not yet been described. The authors' employed laser speckle contrast imaging to monitor blood perfusion in a rotational flap from t
Mount Lovćen holds significant cultural, political and religious symbolism in Montenegro, especially due to the fact that the mountain is the last resting place of the prince-bishop and national poet Petar II Petrovich-Njegoš (1813–1851). In the twentieth century the grave of Njegoš has undergone profound material transformations. Each of these transformations has led to heated debates about the s
Outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) have improved because of advancements in equipment and techniques. With global collaboration and knowledge sharing, we have identified 7 common principles that are widely accepted as best practices for CTO-PCI. 1. Ischemic symptom improvement is the primary indication for CTO-PCI. 2. Dual coronary angiography and in
Sizing of borehole heat exchangers (BHEs) for direct ground cooling systems (DGCSs) is a critical part of the overall system design. This study investigates the thermal performance and sizing of a DGCS with two different operation strategies using experimental and simulation approaches. The traditional on/off operation strategy keeps a constant room temperature. The continuous operation strategy h
This study investigated the tolerance and safety of pasteurized donor human milk (PDHM) given either alone or together with commercially-used supplements in a porcine model of premature infants. A porcine model, mimicking human neonates at 30-32 weeks of gestational age, was used. The 7-day experiment was performed on 20 piglets. After birth, the piglets were infused with porcine immunoglobulins v
This study analyzes the association between neighborhood social class in childhood and later-life health trajectories, controlling for both class origin and class attainment in adulthood. We study the association between socio-spatial neighborhood conditions throughout childhood and a range of health outcomes in adulthood. To measure childhood conditions, we utilize unique longitudinal micro-data
The study aimed to investigate socioeconomic factors in patients with carpal tunnel syndrome (CTS) and to evaluate their impact on outcome following open carpal tunnel release (OCTR). Data from the National Quality Register for Hand Surgery were combined with socioeconomic data (marital status, education level, earnings, migrant status, occupation, sick leave, unemployment, and social assistance)
Background: The risk of sustaining a contra-lateral anterior cruciate ligament (C-ACL) injury after primary unilateral ACL injury is high. C-ACL injury often contributes to a further decline in function and quality of life, including failure to return to sport. There is, however, very limited knowledge about which risk factors that contribute to C-ACL injury. Objective: To systematically review in
We test for age and metallicity gradients in the Galactic Bulge between the two low extinction windows Baade's window (l = 1°.1 b = -4°.8) and Sagittarius-I (l = 1°.3 b = -2°.7). We derive a metallicity difference of ≤ 0.2 dex between BW and SGR-I window. This corresponds to a metallicity gradient of 1.3 dex kpc-1. This steep gradient is reconcilable with the existence of a short scale length inne
