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The intrinsically disordered MYC proteins are master regulators of cellular growth and function, but when deregulated they become cancer drivers. MYC-protein interactions are key to oncogenesis, and while disrupting such interactions would be of significant therapeutic benefit, the intrinsically disordered properties of MYC have dramatically hampered their characterization. Here, we apply an integ
This paper presents the primary charged-particle multiplicity distributions in proton–lead collisions at a centre-of-mass energy per nucleon–nucleon collision of sNN=5.02 TeV. The distributions are reported for non-single diffractive collisions in different pseudorapidity ranges. The measurements are performed using the combined information from the Silicon Pixel Detector and the Forward Multiplic
The efficiency and durability of Polymer Electrolyte Fuel Cells (PEFCs) depend on optimizing porous media components such as gas diffusion and catalyst layers. In parallel, the Lattice Boltzmann Method (LBM) has emerged as a powerful tool to model fluid flow, mass transport, and multiphase interactions in complex porous structures. This works provides a concise overview of recent advances in apply
The electrification of the transportation sector is a central strategy for decarbonization, yet it raises concerns about the capacity of existing electric power grids to meet increasing demand. This thesis investigates the interaction between large-scale electrified vehicle fleets and the electric power system under the assumption of full transport electrification. The focus is on assessing the re
Background: Policy advocacy (PA) in European healthcare has a strong tradition promoting evidence-based policies. Key organisations, including the European Observatory on Health Systems and Policies, the WHO’s Evidence-Informed Policy Network, and the OECD play pivotal roles in integrating research into policymaking. Objectives: To assess the involvement of European Family Medicine (FM) Associatio
The Circular Economy (CE) concept is widely promoted as a pathway to sustainability, yet its practical realization can appear to be challenging and unclear due to divergent definitions, interpretations and understanding about the implications and goals of a realized CE. Addressing this gap, this study develops the Circular Economy Loop Strategies (CELS) Framework, a synthesizing foundational model
With sea-level rise and increasingly frequent extreme weather events threatening communities, ecosystems and built infrastructure alike, climate change adaptation is pressing. This remains true in high-income countries where research capturing power dynamics underpinning adaptation continues to develop with implications for how policy and exclusion can be understood. Through a systematic review, t
Finding the optimal subset of individuals to observe in order to obtain the best estimate of the average opinion of a society is a crucial problem in a wide range of applications, including policy-making, strategic business decisions, and the analysis of sociological trends. We consider the opinion vector X to be updated according to a DeGroot opinion dynamical model with stubborn agents, subject
Strengthening international climate governance is seen as pivotal for advancing the Sustainable Development Goals (SDGs). However, a systematic understanding of their dynamic interactions remains limited. Given the strong interconnections among the SDGs, climate governance policies designed to advance one goal can significantly influence progress on others, highlighting the need for an integrated
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) represents a growing clinical threat due to convergence of resistance and virulence determinants. We conducted a multicenter genomic epidemiology study analysing CR-hvKp isolates collected from 19 tertiary-care hospitals across Türkiye between 2018 and 2023. CR-hvKp isolates were subjected to whole-genome sequencing to investigate
Background: Inadequate postoperative pain management after lumbar discectomy may delay recovery, increase the risk of chronic pain, and prolong hospitalization. Effective analgesic strategies must balance pain control with minimal adverse effects. Objective: To identify the most effective postoperative analgesic interventions for patients undergoing lumbar discectomy. Databases and Data Treatment:
The article examines Europeanisation processes at the Spanish University of Valladolid (UVa) in the years around Spain’s adhesion to the European Communities in 1986. This event has often been seen as key to the Spanish transition to democracy, which had begun after the death of Francisco Franco in 1975. Drawing on a variety of source materials, the article shows that Europeanisation at the UVa in
Natural resource extraction often takes place in locations where communities are not financially well-off and where historically marginalized groups reside. This paper contributes to the policy debate by revealing how corporate social licence tactics enable a model of corporate-community manipulation which is similar across different geographical contexts. Original data gathered between 2016 and 2
Coffee is the most common drink in the world, second only to water. This makes caffeine, the ingredient of coffee known for its wakefulness-promoting effects, one of the most used psychoactive substances. The psychoactive property of caffeine is well-characterized, and entails its interaction with the adenosine receptors, involved in sleep regulation. While studies have shown a deleterious immedia
Sentinel lymph node biopsy (SLNB) remains the standard method for axillary staging in breast cancer. However,for the majority of patients with early breast cancer, it offers no treatment benefit and carries a risk of long-termside effects. In the era of surgical de-escalation, reliable preoperative assessment of axillary lymph node metastasis isessential to avoid overtreatment and support treatmen
Urban meteorology, the study of atmospheric phenomena in urban areas, is vital for understanding the dynamic interactions between rapid urbanization and environmental changes. Over the past two decades (2004–2024), urban heat islands (UHIs), extreme rainfall, pollution, and temperature anomalies have intensified, adversely affecting human health, infrastructure, and ecosystems worldwide. The prese
Background: Increasing healthcare demands and a growing nursing shortage contribute to high workloads, psychosocial strain, and risks to care quality. Organisational conditions, job demands, and resources strongly influence nurses’ well-being, retention, and performance. Aim: To examine how nurses balance organisational demands and opportunities, and how these factors relate to work environment, w
Background and Objectives – Limbic-predominant age-related TDP-43 encephalopathy (LATE) is characterized by an amnestic- and limbic-predominant phenotype, which can mimic Alzheimer disease (AD). In a memory clinic cohort, we tested whether clinical criteria for LATE can detect a clinical profile of LATE that is distinct from AD.Methods – In this retrospective examination of a longitudinal memory c
This study tests the viability of multiple sorting tasks (MST) as a method to explore perceptions of public space and its potential for people that are vulnerable to loneliness. The procedure integrates qualitative and quantitative aspects and obviates the challenge of people articulating how they interact with their surroundings, especially being aware of what features of their environment are in
