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PURPOSE: Radiation to the bone and exposure to alkylating agents increases the risk of bone cancer among survivors of childhood cancer, but there is uncertainty regarding the risks of bone tissue radiation doses below 10 Gy and the dose-response relationship for specific types of chemotherapy.METHODS: Twelve European countries contributed 228 cases and 228 matched controls to a nested case-control

Aims Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incompletely understood. The aim of this study was to discover novel genetic contributors to AS and to integrate functional, expression, and cross-phenotype data to identify mechanisms of AS. Methods and results A genome-wide meta-analysis of 11.6 million variants in 10 cohorts involving 653 867 European

The best validated susceptibility variants for Parkinson's disease are located in the α-synuclein (SNCA) and microtubule-associated protein tau (MAPT) genes. Recently, a protective p.N551K-R1398H-K1423K haplotype in the leucine-rich repeat kinase 2 (LRRK2) gene was identified, with p.R1398H appearing to be the most likely functional variant. To date, the consistency of the protective effect of LRR

BACKGROUND Sentinel-lymph-node biopsy is associated with increased melanoma-specific survival (i.e., survival until death from melanoma) among patients with node-positive intermediatethickness melanomas (1.2 to 3.5 mm). The value of completion lymph-node dissection for patients with sentinel-node metastases is not clear. METHODS In an international trial, we randomly assigned patients with sentine

OBJECTIVE: To investigate the influence of common and low-frequency genetic variants on the risk of ischemic stroke (all IS) and etiologic stroke subtypes.METHODS: We meta-analyzed 12 individual genome-wide association studies comprising 10,307 cases and 19,326 controls imputed to the 1000 Genomes (1 KG) phase I reference panel. We selected variants showing the highest degree of association (p < 1

It has been hypothesized that low frequency (1-5% minor allele frequency (MAF)) and rare (<1% MAF) variants with large effect sizes may contribute to the missing heritability in complex traits. Here, we report an association analysis of lipid traits (total cholesterol, LDL-cholesterol, HDL-cholesterol triglycerides) in up to 27 312 individuals with a comprehensive set of low frequency coding varia

Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals, including 13 new risk loci. The novel associations nearly double the number of genome-wide hits repo

The neutron-deficient mercury isotopes serve as a classical example of shape coexistence, whereby at low energy near-degenerate nuclear states characterized by different shapes appear. The electromagnetic structure of even-mass 182-188 Hg isotopes was studied using safe-energy Coulomb excitation of neutron-deficient mercury beams delivered by the REX-ISOLDE facility at CERN. The population of 01,2

Examensarbete VT 2021 Master’s Dissertation Structural Mechanics Report TV SM -5252 G U STA F O LA U SSO N SH EA R STIFFN ESS O F C R O SS LA M IN A TED TIM B ER D IA PH R A G M S - A stu d y o f th e in fl u en ce o f co n n ectio n an d m em b er stiffn ess GUSTAF OLAUSSON SHEAR STIFFNESS OF CROSS LAMINATED TIMBER DIAPHRAGMS A study of the infl uence of connection and member stiffness DEPARTMENT

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5252.pdf - 2026-04-20

Framsida Sthlm (kopia) WPSS WORKING PAPERS IN SCANDINAVIAN SYNTAX June 2019 Issue 102 Working Papers in Scandinavian Syntax is an electronic publication for current articles relating to the study of Scandinavian syntax. The articles appearing herein are previously unpublished reports of ongoing research activities and may subsequently appear, revised or unrevised, in other publications. The WPSS h

https://projekt.ht.lu.se/fileadmin/user_upload/sol/ovrigt/projekt_grimm/working_papers/2019_June/WPSS102.pdf - 2026-04-20

Forskarutbildningsenkäten doktorander 2019 Forskarutbildningsenka ten doktorander 2019 SAMMANFATTNING John Jönsson, Avdelningen för kvalitetsstöd, LTH. jo5480jo Textruta Dnr U 2019/559 1 Innehåll 2 1. Inledning Föreliggande rapport redovisar resultatet av Forskarutbildningsenkäten doktorander som genomfördes vid LTH under våren 2019. Syftet med enkäten är att följa upp doktorandernas utbildning sy

https://www.lth.se/fileadmin/lth/anstallda/kvalitet/Resultat_i_kvalitetssystemet/Uppfoeljning_FU/Resultat_forskarutbildningen/Rapport_Forskarutbildningsenkaeten_doktorander_2019.pdf - 2026-04-20

1 Master Programme in International Human Rights Law 2017 - 2019 FACULTY OF LAW AND PUBLIC AFFAIRS 2 The Master Programme in International Human Rights Law is offered by the Faculty of Law and Public Affairs at Paññasastra University of Cambodia (PUC-FLPA). Of- fered in English language, it is an international level pro- gramme that draws on the academic and practitioner strengths of the Faculty a

https://rwi.lu.se/app/uploads/2017/03/PUC2017web-Final.pdf - 2026-04-21

Popular Abstract in Swedish De två studier som presenterats i föreliggande avhandling avser att belysa sambandet mellan den administrativa organisationen av skolan och rektors möjligheter att leda den pedagogiska verksamheten. Vidare avser den att granska sambandet mellan lärargruppens anda och tillfredsställelsen med rektors ledarskap. Studierna avser också att granska hur rektors förmåga att etaThe thesis focuses on the elementary school principal’s formal responsibility and role in connection with his spatial and psycho-social nearness to the teachers. On one hand it is a comparison between schools in Sweden and Iceland, while on the other hand it is a case study of the principal’s leadership in several different school organisations. These studies are based on the theory that even if t

Popular Abstract in Swedish Nyligen genomförda undersökningar pekar på att mellan en och två procent av den vuxna befolkningen lider av hjärtsvikt (hjärtinsufficiens/hjärtinkompensation), en oförmåga hos hjärtat att med ett normalt fyllnadstryck förse kroppens olika organ med blod. Vanligtvis är orsaken primärt kardiell (utgående från hjärtat) där ischemisk hjärtsjukdom (kranskärlssjukdom) utgör dUse of beta-blockers and inhibitors of the renin angiotensin system (RAS) is established practice in the treatment of chronic heart failure (CHF). Clinical studies also suggest beneficial long-term effects of nitrates in CHF. In the Veterans Administration Heart Failure Trial (V-HeFT) I, the combined use of a nitrate and hydralazine reduced the mortality rate. However, it is not possible to determ

This explorative study aimed to apply, develop, and evaluate assessment methods at various levels in cell replacement therapy for Parkinson’s disease (PD). Observed motor effects in five grafted patients support that timed motor tasks and clinical ratings of parkinsonism are able to monitor motor function, but their psychometric properties need further attention. Using positron emission tomograp

The general aim of this thesis was to explore relationships between functional capacity, environmental factors, everyday activity, and health in the elderly population. Initially, the Enabler, an instrument for assessment of the physical home environment's accessibility, was translated to Swedish and revised, and tested for reliability and validity. Further, a systematic random sample of individua

Popular Abstract in Swedish Populärvetenskaplig sammanfattning Kardiovaskulär sjukdom (CVD) är ett i vårt samhälle växande problem där allt fler insjuknar i akuta hjärtinfarkter, stroke eller hjärtsvikt. Överlevnaden efter insjuknandet har förbättrats med åren med hjälp av nya mediciner och invasiva ingrepp såsom stentning av kranskärlen vid svår kärlkramp och direkt i det akuta skedet vid vissa tThis thesis examines the relationship between measures of renal function and cardiovascular disease (CVD) in patients with hypertension (the NORDIL study) and in the healthy population (Malmö Diet and Cancer Study, MDC) and whether antihypertensive treatment response and the risk of CVD is affected by genetic variation of a regulator of the renal amiloroide sensitive sodium channel (NORDIL). In st

Popular Abstract in Swedish Det är en utbredd uppfattning att gränserna mellan högkulturen och masskulturen blivit mindre skarpa i vår postmoderna kultur. Den höga litteraturen lånar friskt former, motiv och grepp från masskulturen – och viceversa. Hur skall man tolka den estetiska trafiken mellan kulturella sfärer – höga respektive låga – som länge ansetts oförenliga? Vad består trafiken av och The Struggle for High and Low Culture. Studies in the Late Twentieth Century Novel’s Relationship to Mass Culture and Modernity. It is a widespread opinion that the boundaries between high culture and mass culture have become less defined in our postmodern culture. How is the aesthetic exchange to be interpreted between cultural spheres – high and low respectively – long considered incompatible?

Popular Abstract in Swedish Ärftliga näthinnesjukdomar med tidig debut Elektrofysiologiska och genetiska studier Ärftliga näthinnesjukdomar är den vanligaste orsaken till allvarligt synhandikapp hos unga människor i dagens Sverige. De flesta av dessa sjukdomar kan ännu inte behandlas, men vi har under de senaste åren fått allt större insikt i de bakomliggande sjukdomsmekanismerna, tack vare att Hereditary retinal degenerations are the most frequent reason for severe visual handicap among young people in Scandinavia today. In the six papers included in this thesis the phenotypic expressions, with emphasis on the electrophysiological findings, of five different juvenile hereditary retinal degenerations are described. The diagnoses have been confirmed by genetic analysis. The retinal disord