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Traumatic brain injury is widely viewed as a risk factor for dementia, but the biological mechanisms underlying this association are still unclear. In previous studies, traumatic brain injury has been associated with the hallmark pathologies of Alzheimer's disease, i.e. amyloid-β plaques and neurofibrillary tangles comprised of hyperphosphorylated tau. Depending on the type and location of trauma,
Objectives: In this nationwide cohort study in a Scandinavian setting, we aimed to investigate the magnitude of association between flucloxacillin use and drug-induced liver injury (DILI). Methods: Nationwide cohort study among adults in Sweden, 2006–2018, was conducted. Register data on filled prescriptions, patient characteristics, co-medications, and DILI were linked. All filled prescriptions f
INTRODUCTION: The generalizability of neuroimaging and cognitive biomarkers in their sensitivity to detect preclinical Alzheimer's disease (AD) and power to predict progression in large, multisite cohorts remains unclear. METHOD: Longitudinal demographics, T1-weighted magnetic resonance imaging (MRI), and cognitive scores of 3036 cognitively unimpaired (CU) older adults (amyloid beta [Aβ]-negative
At the core of this artistic research project is the idea that composing music can entail more than structuring sonic material; it may involve constructing the very space in which musical thoughts take shape. This space, the composable, is understood not as a fixed, pre-existing framework but as a space in flux—shaped by instruments, devices, spatial configurations, and performative gestures—where
Background: Differentiated thyroid carcinoma (DTC) is occurring three times more frequently in females than in males. However, the underlying biological mechanisms driving this discrepancy remain poorly understood. To investigate the causal role of sex hormones and reproductive factors in the risk of DTC, we implemented a two-sample Mendelian randomization (MR) analysis. Methods: We utilized genom
This paper analyses the effects of new public management governance on academics’ job choices. Based on a choice experiment carried out with faculty from a sample of Germany’s leading technical universities, we find that working environments characterized by varying levels of administrative burdens and high expectations concerning third-party funding acquisition are detrimental to self-actualizati
While the importance of breastfeeding on the developing infant gut microbiota has been established, few studies have compared the effect of breastfeeding duration on infant gut microbiota development. In this pilot study, we included 23 infants, divided into 4 groups to compare the effect of breastfeeding duration for first 4 (BreastFed_4) or 8 weeks (BreastFed_8) compared to exclusive breast
In this chapter, we evaluate how the concept of the entrepreneurial ecosystem - a systemic approach to regional economic development that is receiving increased attention from both policymakers and academics - can assist in analysing and understanding the informal economy. We argue that despite the focus of entrepreneurial ecosystems on high-growth entrepreneurship, the ‘systemic’ perspective of t
Industry 4.0 concepts have recently significantly supported transparency and reliability in every industrial sector. Organizations must adapt their traditional paradigms and approaches to align with market demands. Hence, developing a framework that can change these conventional approaches with fresh ideas is essential. The Industry 4.0 (I4.0) readiness model presents a creative concept that holds
Background: Individualized cancer rehabilitation should be an integral part of cancer care. Contact nurses play a key role in identifying patient needs and coordinating evidence-based interventions to support rehabilitation. However, cancer rehabilitation remains marginal in current practice, as contact nurses face challenges due to the lack of systematic processes for assessment, intervention, an
Nurses are essential pillars of society, providing care for the sick. It is crucial for society to ensure that nurses have favorable working conditions, as they face a heightened risk of negative psychological conditions such as depression, anxiety, stress, and emotional exhaustion due to the demanding nature of their work. The strain on healthcare staff, particularly during the COVID-19 pandemic,
Background: Differences in the expression of regulatory T cells (Tregs) have been suggested to explain why some smokers develop COPD and some do not. Upregulation of Tregs in response to smoking would restrain airway inflammation and thus the development of COPD; while the absense of such upregulation would over time lead to chronic inflammation and COPD. We hypothesized that—among COPD patients—t
AIMS: Comparisons of international practice patterns and their impact on percutaneous coronary intervention (PCI) outcomes are lacking. We compared temporal PCI trends between Sweden and a large university hospital system in the US.METHODS AND RESULTS: Data within the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) and the University of California San Diego Health internal National C
This presentation focuses on a project at an early stage of development. The aim of the practice lab project is twofold: (i) to strengthen the competence among students in higher music education with regards to the topic of practice, and (ii) contribute to research on musical practice and skill acquisition. The project is conducted at Malmö Academy of Music (Lund university). Students take part in
Polarized fluorescence microscopy is a valuable tool for measuring molecular orientations in biological samples, but techniques for recovering three-dimensional orientations and positions of fluorescent ensembles are limited. We report a polarized dual-view light-sheet system for determining the diffraction-limited three-dimensional distribution of the orientations and positions of ensembles of fl
We explore the transformative potential of SAM 2, a vision foundation model, in advancing gaze estimation. SAM 2 addresses key challenges in gaze estimation by significantly reducing annotation time, simplifying deployment, and enhancing segmentation accuracy. Utilizing its zero-shot capabilities with minimal user input—a single click per video—we tested SAM 2 on over 14 million eye images from a
We investigate experimentally the quantum coherence of an electronic two-level system in a double quantum dot under continuous charge detection. The charge state of the two-level system is monitored by a capacitively coupled single quantum dot detector that imposes a backaction effect on the system. The measured backaction is well described by an additional decoherence rate, approximately linearly
AIM: To illuminate from the perspective of nurses in ambulance services the experiences of using a web-based advisory decision support system to assess care needs and refer patients.DESIGN: Inductive and descriptive approaches.METHOD: Thirteen semi-structured interviews were conducted in the spring of 2020. The data were analysed through the reflexive thematic analysis.RESULTS: The Swedish web-bas
